RE: Cohort 7 (again)21 Oct 2023 11:00
Apologies for the turmoil on my phone this morning
Here is the crux paragraph from the link ref myelosuppression. The poster can be found on the Avacta website
" AVA6000 utilises Avacta's pre|CISION™ platform to improve the safety and therapeutic index of doxorubicin. AVA6000 has been designed to limit cell penetration of the drug, and therefore its cell killing effect, until it is specifically activated FAP, which is in high concentration in many solid tumours compared with healthy tissues. The resulting reduced exposure of healthy tissues to active doxorubicin has the potential to significantly increase its therapeutic index by reducing the incidence of adverse effects, including cardiotoxicity and myelosuppression. A first-in-human Phase I clinical trial (ALS-6000-101) has been initiated in the UK in a broad spectrum of high FAP expressing tumours."