RE: i said this would be big (part 4)26 Feb 2023 21:07
Evening LB,
In answer to your queries last night,,,,,
I know bugger all about mining, so we can both help each other out here!
Dawn Coverley has approx 45 or so medical publications in her own name, but there are loads more that cite her as the principle author/contributor to other published papers. Also, watch for papers where Justin Ainscough is credited.
Regards the one or two patents, there are actually 13 fully granted patents worldwide, a further 5 that are pending and a handful that were lapsed/abandoned as they were not focused on the initial platform that Fujiburo were looking for some years previously. There may well be a few more that are being complied at present as our progression continues.
Of those pending, there are a number that are partially granted, in that a patent is filed with "claims" Some of the claims are accepted, and some are disputed.
On the issue of protection of our patent, we are pretty well covered, even against copycat cases, as it is the technology and execution of the assembly of the reagents and antibodies that are the core.
Doesn't really matter how big the big boys are, as our intellectual property is already patented and protected. (though i take the point of their deeper pockets)
I will use a very simple analogy of grafting fruit trees to try and explain the process as i understand it. (weird i know, but stay with me...)
CIZ1 is the nuclear protein. Lets call this the rootstock of a fruit tree.
For lung cancer detection, we need to "graft" a variant of the protein which is the B variant. Lets call this the apple tree.
This gives us CIZ1-B. The B variant is what is known as being the exon. (exon 14 in this case)
Where we graft it onto the rootstock is the junction (or cut if you like)
Now, lets call the antibodies and reagents, soil or compost, and fertilizer. By using different compost composition, and using different types and strengths and combinations of fertilizers, we get the best growth, and fruit bearing tree, and know that it is perennial (by that i mean repeatable) This is very simplistically what the assay optimisation is.
Now, the next test we want to develop is to detect breast cancer.
So we now need to graft a different fruit on a rootstock.
Lets call this one a cherry tree.
This will be a different variant, requiring a different exon junction, so may be CIZ1-S, and the process above will be carried out again.
As you say, it's a race to get to the" garden centre", but we need to make sure that these "fruit trees" aren't susceptible to disease, and can produce the best fruit, and be the same every time.
Hope this helps to visualize what i am trying to get at.
Can't remember the date, but last year or so, i posted about M&A activity, and who was buying who out, along with the ridiculous amounts they paid. One name i mentioned keeps on coming up again, and again,.
Neil
Read into that what you will. ;-))
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