Proceedings of the Twenty-First International Society of Sports Nutrition (ISSN) Conference and Expo15 Dec 2024 17:40
Impact of LeanBiome® intake on glycemic response, satiation, and gut microbiome diversity in healthy adults
Zac Sinderman, (sic) Oana A, Enzver Keleszade, Sofia Kolida, Adele Costabile
OptiBiotix Health Plc. Innovation Center, Innovation Way, Heslington, York, Y010 5DG, UK; bDepartment of Life Sciences, University of Roehampton, United Kingdom
Corresponding Authors: Zac Sniderman, zsniderman@optibiotix.com
Background: The aim of this study was to investigate the impact of the intake of LeanBiome®, (chromium enriched glucomannan-fructooligosaccharide complex) on glycemic and insulin response, satiation, and hunger biomarkers in healthy adults. LeanBiome® has been shown to support body fat reduction and to promote gut microbiome diversity, while reducing fat intake, and food cravings in human intervention studies.
Methods: Using a double-blind, placebo-controlled, crossover study design we assessed the acute impact of the intake of a single LeanBiome® dose in 20 healthy adults (10 males, 10 females; BMI 18.5-24.9 kg/m2, 18-65 years; fasting blood glucose 4-7 mM), undergoing an oral glucose tolerance test. Volunteers ingested 50 g of available carbohydrates (dextrose) and 50 g dextrose supplemented with 3 g LeanBiome® (LBdextrose) on separate days. Test interventions were blind packaged and dissolved in 250 ml water. Blood samples were obtained at 0 min (fasting) 15, 30, 45, 60, 75, 90, 120 min and 150 min post intervention intake. Feelings of hunger, fullness, desire to eat, and amount of food desired were assessed at 0, 75 and 150 min using the visual analogue scale. The impact of daily LeanBiome® intake over a 4-week period as part of a calorie-controlled diet program was then assessed in 12 overweight and obese adults (18-65 years, BMI 25-35 kg/m2). Anthropometric parameters, mood and cravings were recorded, and fecal samples were collected for metagenomic analysis. All studies were conducted according to SPIRIT requirements and CONSORT guidelines and have been approved by the University of Roehampton Research Ethics Committee (LSC 18/238).
Results: LBdextrose intake reduced both the glucose and insulin peak when compared to the intake of dextrose alone. Volunteer scores on appetite related parameters did not differ significantly between dextrose and the LBdextrose tests at baseline. At 75 min the feeling of fullness was significantly higher in the SBdextrose compared to dextrose alone (P < 0.05), while the desire to eat was significantly lower compared to dextrose. At 150 min, although hunger scores increased compared to baseline for both tests, SBdextrose scores remained significantly lower compared to dextrose (P < 0.05). Similar effects were noted for desire to eat, and the amount of food volunteers felt they could eat. Fullness for the SBdextrose was significantly higher (P < 0.05) compared to dextrose and the baseline values.
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