Member Info for maximillion69

What EAF151 Means for IB Neuro™ & Bevacizumab Decision-Making in Recurrent GBM

EAF151 (Abstract), a prospective phase 2 clinical trial (33 sites, n=146), was designed to evaluate whether dynamic susceptibility contrast MRI-derived relative cerebral blood volume, or rCBV, could serve as an early imaging biomarker of response to bevacizumab in patients with recurrent GBM.

This is especially important because bevacizumab can produce imaging changes that make conventional MRI interpretation more challenging, including reductions in enhancement that may not represent the true underlying tumor biology.

In the EAF151 analysis, IB Delta T1 maps were used in all exams to identify true regions of contrast enhancement. Then, IB Neuro computed both normalized and standardized rCBV metrics. While both were shown to be significant, standardized rCBV (exclusive to IB Neuro) demonstrated a stronger statistically significant overall survival signal, while also offering the clinical advantage of fully automated and more consistent processing.

For clinicians, the takeaway is clear:

When treatment decisions are complex, qualitative imaging alone may not be enough.

IB Neuro translates DSC-MRI perfusion data into objective, consistent and reproducible metrics that can support:

Earlier insight into treatment response

More informed bevacizumab decision-making

Standardized rCBV analysis across MRI platforms

Automated workflows that reduce manual post-processing burden

Greater confidence when conventional imaging is ambiguous

In recurrent GBM, timing matters!

Ahaaa Semantic !!

Where have you been !!

Nigh on 50% spread ! Ahh

Presentation

https://www.asco.org/abstracts-presentations/267325

Tyke

Nothing yet sorry

A UT trade at .55p it will feel

Like a positive day tomorrow .

Https://www.linkedin.com/posts/zeroemission-ire2026-ire2026-ugcPost-7465116175795019778-5fyg/?utm_source=share&utm_medium=member_ios&rcm=ACoAAAkyjQ0B7bMMkoLn8XD8s2HLk9vizWE-zfc

I’ve actually had you referred on a search .

Yes Tyke

That’s how AI works and why you seem to have heard it all before.

Tyke

My first thought was yay but as ive no access to full file and after asking AI my yay diminished .

What’s new lol

Https://www.sciencedirect.com/science/article/abs/pii/S0031699726000268

Tyke

all very confusing , keep asking the questions , keep discussing, we need to know .

The technology outlined in Patent US12542214B (and its related applications) focuses on a highly resilient, fully automated deep learning framework for semantic medical image segmentation. This system is engineered to mitigate the standard "brittleness" of deep learning algorithms when they confront variations in medical scan quality, different hospital scanners, and unique patient anatomy

Not sure if I'm reading the patent right or reading you right Tyke

My take of the Patent is that of a Method utilising deep learning medical imaging to mitigate variations in medical scanners , the IB Neuro video and KS connection suggest the IB Neuro platform was used as part of process .

In all accounts please correct if thought differ .

Maybe one for Howdlep to AI analyse .

Just a little pick up from the IB NEURO video

patent awarded to MCW FEB 03 2026 , inventor KS

https://patents.google.com/patent/US12542214B2/en

Ive certainly made a few math mistakes here worse than my spelling !

2 shares Trev is sending you coded messages

Tyke

Are you suggesting TB/TRUE have to buy 1 share at a time to monitor % , wouldn't want to go over . lol

Https://www.linkedin.com/posts/mrendall_ammoniacracking-hydrogen-share-7461771492629057536-Dfbs?utm_source=social_share_send&utm_medium=ios_app&rcm=ACoAAAkyjQ0B7bMMkoLn8XD8s2HLk9vizWE-zfc&utm_campaign=copy_link

Thanks Tyke

For all your efforts

Have a good weekend

Name change see HPOW