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Biotech
Feb 12, 2026
Genflow reveals early data from SIRT6 gene therapy trial in dogs
Danny Sullivan
Preliminary results indicate that treated animals demonstrated ‘superior survival’ and functional improvements compared to the control group.
It’s a good week to be a dog. Hot on the heels of Loyal raising $100m to gear up for commercialization of its canine longevity drug, longevity biotech Genflow Biosciences today announced preliminary interim findings from a clinical study evaluating its SIRT6 gene therapy in aged dogs. The London-based company, founded in 2020 to develop gene therapies targeting age-related disease, sees the program as both an opportunity in companion animal health and a stepping stone toward human applications.
The SIRT6 gene has attracted significant attention in the longevity field because of its role in DNA repair and genome stability, and research indicating that enhancing its activity may influence lifespan and resilience in animal models. By first applying its technology in companion animals, Genflow hopes to build clinical evidence that could also inform human therapeutic development.
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Today’s data come from the SLAB (Sarcopenia and Longevity in Aged Beagles) trial, where 24 beagles aged 10 years or older were enrolled and assigned across four groups, including two naked DNA treatment cohorts at different dose levels, a single-dose AAV8 cohort, and an untreated control arm. The proof-of-concept study was first announced last year and focuses on assessing whether delivery of a variant of the SIRT6 gene can mitigate functional decline associated with aging.
According to the interim analysis announced by Genflow today, all treatment groups showed “superior survival” compared with the control animals during the dosing period. Beyond survival outcomes, the company says that treated animals displayed improvements across several functional indicators, including quality of life measures, maintenance of muscle mass, reductions in frailty scores and visible changes such as coat condition. Control animals followed a more typical trajectory of age-related decline.
Dr Eric Leire, founder and CEO of Genflow Biosciences
“The consistency of positive signals across multiple independent endpoints from survival and quality of life to measures of muscle preservation and frailty reduction, combined with an excellent safety profile, supports our SIRT6 platform as a credible, differentiated asset for the companion animal market,” said Genflow C