Member Info for LiveLongnProsper

Just for info FWIW, as I recall someone suggesting that this site was somewhat ‘automated’.

https://www.withpower.com/trial/phase-1-sarcoma-6-2021-6f477

But it has switched from Colorectal, to Oesophageal (and back again), and now on STS – in the last couple of months.

GLA

Comparison of Sep vs Aug (unless stated).

Daily average production 1148 (30 days) vs 1146 (31 days). So, basically the same.

Top 6 (over 2000) …

BFU 34-20V, 3633 +435 on -2 days, -8 days lost overall

BFU 32-27V, 3168 -237 on -1 days, producing for 30 days

BFU FED 32-21V, 2899 +417 on 29 days

BFU 44-22V, 2633 -270 on 29 days

BFU 21-35-76 ST A SN 3H, 2335 +269 on +9 days, producing for 30 days

BFU Fed 11-22V, 2042 -1081, producing for 29 days (something ‘up’ here then?)

4 more producing 1000+

26 more producing oil, total 36 wells with production.

Biggest improvers …

COLE CREEK 31-17, +567 vs 0, on 30 (vs 0) days

BFU FED 11-28V, +494 on 30 (vs 17) days

BFU 34-20V, +435 on 22 (vs 24) days (high gas at 14631)

BFU FED 32-21V, +417 on 29 (vs 29) days

BFU FED 21-21V, +362 on 30 (vs 21) days

Another 8 with increases, total 13 improvers.

Worst ‘offenders’, one stands out …

BFU Fed 11-22V, -1081 on 29 (vs 28) days

Another 21 on the downside.

Gas produced up a bit, water up ~+54%.

Overall, nothing massively different to Aug. So let’s hope that we’ve been ‘off the throttle’ during field works and pending increased injection.

GLA

Tea in pot, cosy (hand knitted of course) on.

Yorkshire tea (data) brewing (being analysed).

Will be pouring a nice cuppa (of results) soon.

Looking forward to the biscuits.

GLA

Point Biopharma (Eli Lilly acquisition target) have PNT2002 “a PSMA-Targeted therapy for metastatic castration-resistant prostate cancer”. This utilises “the beta-emitting radioisotope lutetium-177”.

https://www.pointbiopharma.com/our-products/pipeline/prostate-cancer

Novartis have Pluvicto™ which “shows clinically meaningful and highly statistically significant rPFS benefit in patients with PSMA-positive metastatic castration-resistant prostate cancer”. Pluvicto™ is based on the radioisotope lutetium (177Lu).

https://www.novartis.com/news/media-releases/novartis-pluvictotm-shows-clinically-meaningful-and-highly-statistically-significant-rpfs-benefit-patients-psma-positive-metastatic-castration-resistant-prostate-cancer-pre-taxane-setting

Note that there are side effects, see down the page.

Prostrate cancer is one of the higher FAP expressing tumour types – as per below, and as referenced by Avacta …

https://jnm.snmjournals.org/content/jnumed/60/6/801.full.pdf

Novartis seem to have missed out on CanSEEK™, so maybe they’re looking for the full platform?

GLA

OK, so would appreciate some insight into what’s going on here? Matched pairs at the same price, XOFF, posted after hours, and has been a regular occurrence recently. Delayed posting result of order fill maybe, but what about the small ones, etc.? Today’s …

2023-10-20T16:55:38+01:00 GBP 1.28084 992 1,269.76 Off-book XOFF

2023-10-20T16:55:37+01:00 GBP 1.28987 100000 129,000 Off-book XOFF

2023-10-20T16:55:37+01:00 GBP 1.28508 214229 276,355.41 Off-book XOFF

2023-10-20T16:55:37+01:00 GBP 1.29987 15029 19,537.7 Off-book XOFF

2023-10-20T16:54:26+01:00 GBP 1.28083 992 1,269.76 Off-book XOFF

2023-10-20T16:54:25+01:00 GBP 1.28987 100000 129,000 Off-book XOFF

2023-10-20T16:54:25+01:00 GBP 1.28507 214229 276,355.41 Off-book XOFF

2023-10-20T16:54:12+01:00 GBP 1.29987 15029 19,537.7 Off-book XOFF

GLA

@Shouston – looks like we got a bit more oil then!

When August production released …

BFU FED 32-21V Oil, Gas, Water, Days, 1484, 765, 76, 19

BFU Fed 11-22V Oil, Gas, Water, Days, 2381, 208, 39, 18

Current download …

BFU FED 32-21V Oil, Gas, Water, Days, 1570, 765, 76, 19 (+86 barrels oil)

BFU Fed 11-22V Oil, Gas, Water, Days, 2519, 208, 39, 18 (+138 barrels oil)

GLA

10/17/2023 (MDY) - BFU FED 41-22V …

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID87060&nAPINO=948161

SWP requires emergency flaring at the BFU Fed 41-22V (948161) for a safety related well

intervention per Chapter 39 (b)(i). For safety related reasons, SWP needs to install two 5,000 psi casing valves on the

wellhead to secure the well properly prior to restarting offset gas injection. When the offset injection well was injecting gas, the casing pressure on the BFU Fed 41-22V climbed to 2,574 psi. The current casing valves are rated to 3,000 psi. The casing pressure has declined down to 2,100 psi over the last 4 months with the injector shut in. The well needs to be killed in order to swap out the casing valves and we have to bleed down the casing pressure through a flare prior to pumping the well kill. We may need to flare up to a cumulative volume of 7-10 MMcf over a 7-day period.

Interesting that this well doesn’t seem to have produced any oil since Jan 2022? Now upgrading the well-head to facilitate higher pressures and (presumably) reinstate production?

GLA

Quick scan for some heading changes …

Old – “Cellular proteasome activity is inhibited after AVA3996 cleavage”

New – as above plus “resulting in cell death”

Completely new heading – “AVA3996 is selectively cleaved at the tumour resulting in tumor growth inhibition in a melanoma PDX model”

Old – “Initial pre-clinical safety studies”

New – “IND enabling studies”

So, perhaps this one works as well? Now to look through the detail.

GLA

“300 mcf of actual flaring”

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID26383&nAPINO=922922

BFU 23-27V

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID26383&nAPINO=934819

BFU 22-27V - both ‘Notice of intent’ and ‘Subsequent report’

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID26383&nAPINO=934637

Looks like issues dealt with and WOGC happy.

GLA

(The less than sign in front of the 300 mcf seems to be 'control character' that chops off the copy!)

The complete list ...

Flaring requests all approved today …

http://pipeline.wyo.gov/RepByCompsundr.cfm?oops=ID46986&RequestTimeOut=65000&nOpco=1769

FEDERAL 12-26 – annotated “

Flaring requests all approved today …

http://pipeline.wyo.gov/RepByCompsundr.cfm?oops=ID46986&RequestTimeOut=65000&nOpco=1769

FEDERAL 12-26 – annotated “

Another Sundry - dated 10/09/2023 (MDY).

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID25434&nAPINO=922922

Flaring request on FEDERAL 12-26.

“SWP requests approval under Chapter 3 Section 39 (b)(i) to emergency flare up to 1,000 Mcf of gas from October 8-13 due to high line pressures in the field. The problem will be remedied right away to reduce the flared volume from this well.”

So, if the problem is being remedied ‘right away’, then is it being connected to the GGS.

12-26 did 600 barrels in Aug, steady decline since Jan (1333), with increasing amounts of gas produced. Was included in the 2 previous flaring requests.

Field works going on to increase production.

GLA

This is a very clear article that takes you through what Avacta are doing without directly mentioning Avacta (though referenced) or their products / pipeline …

https://twitter.com/avacta/status/1711308768112267489/photo/1

“modified forms of standard chemotherapies that are activated only in the tumour microenvironment (TME) …”

“However, the therapeutic potential of doxorubicin is hindered by injury to non-targeted tissues … limiting therapeutic doses and diminishing the quality of patients’ lives during and after treatment.”

“a wide range of tumour markers has been identified, unlocking the potential to develop more targeted anti-cancer therapies.”

“One particular marker that is over-expressed within the TME is fibroblast activation protein (FAPalpha) …”

“targets like FAPalpha can be exploited to enable the selective targeting and release of the active drug within the tumour tissue.”

“This approach has been validated in proof-of-principle studies and shows promising results in a phase 1a clinical trial.” Ref 6 (NCT04969835 = AVA6000 trial)

“opportunity to incorporate therapeutic agents beyond chemotherapy, unlocking the potential to transform other powerful existing anti-cancer therapies that are limited by systemic toxicity, such as proteasome inhibitors, to treat a broader range of cancers.” Ref 7 (AVA3996)

The article continues in some depth but with allusions to AVA032, AVA028 and AVA021.

Excellent build up to the AACR conference later this week and further data releases.

GLA

The suggestion by Sir Al that Dx might be ‘spun off’ was quite unexpected. Wonder if it took any of his team by surprise?

Launch cost £24m plus up to £13m (max) earn out, and Coris £7.4m plus (max) £3m, let’s say total £48m, plus costs, say ~£55m. Outstanding bond £43.35m (as at 20 Sept).

So, to get our money back / pay off the bond we need (say) ~£55m+, to get our money back and fund Tx (independently) for another couple of years we will need £100m+ for the sale of Dx (i.e. Launch, Coris, plus other bits). Should be achievable once restructuring demonstrates growing revenue and standalone profitability.

Avacta retain all IP for Affimer® (as well as pre|CISIONTM and TMAC), selectively and non-exclusively license Affimers to the ‘spin-off’.

But Sir Al also noted the ‘uptick’ in commercial interest re Tx. BP stake, BP sub-license platform, other permutations short of acquisition? Many options then. Currently funded through H2 2024. Interesting times.

GLA

@Eazy, agree. Both wells have been producing a lot of gas (and flaring) for most of this year. Also both had downtime in recent months.

GLA

Https://webfiles.thecse.com/09_CSE_Form_7_-_Monthly_Progress_Report_-_Sept_2023.pdf?l3QNFdKtZc74_qmNJ1.o.IDIwkNDe7ib

2 – “Management continues working on refinancing its senior debt and obtaining

additional financing for the Issuer’s operation.”

3 – “On September 6, 2023 the Issuer announced a completion of the BFU gas

gathering infrastructure improvement ahead of schedule and under budget.”

14 – conversion shares.

16 – “Effective September 5, 2023, Mr. Arthur Millholland moved from Chief Executive

Officer (“CEO”) and a Director of the Issuer to President of the Issuer’s affiliate,

COPL America Inc. Mr. Arthur Millholland is replaced as CEO by Mr. John Cowan, an Issuer director since 2015. Mr. Thomas Richardson has been appointed as Chairman of the Issuer.”

Ryan still signing off.

(Does look like folks in Wyoming and Canada still doing something then!)

GLA

Actually, reading again I think it's retrospective. Hopefully problems sorted?

GLA

Field 'stuff' happening just now!

http://pipeline.wyo.gov/RepByCompsundr.cfm?oops=ID82708&RequestTimeOut=65000&nOpco=1769

BFU 23-27V

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID8221&nAPINO=934819

Sundry – Subsequent Report 10/03/2023 (

Well 934819 was originally included in the approved order in Docket 775-2022 through April 9,

2023. The well was removed from the approved extension order in Docket 425-2023 good through October 7, 2023. SWP had to emergency flare for 4 days (910 Mcf Cum) in September 2023 due to the commissioning of the new high pressure separator at the wellsite as well as high line pressures in the field from adjustments being made at the processing plant.

BFU 22-27V

http://pipeline.wyo.gov/Wellapi.cfm?oops=ID8221&nAPINO=934637

Sundry – Notice of Intent 10/03/2023 (MDY)

SWP requests approval to emergency flare a cumulative volume of up to 6,000 Mcf for 5-7 days

in October 2023 due to upset operational conditions in the field. The well has experienced a

paraffin plugged flowline. After removing the restriction in the flowline, the well needs to

be flared to drop the tubing pressure prior to turning the gas back to the processing plant

safely. Well 934637 was originally included in the approved order in Docket 775-2022 through

April 9, 2023. The well was removed from the approved extension order in Docket 425-2023 good through October 7, 2023. Sundry – Subsequent Report 10/03/2023 (MDY)

Well 934637 was originally included in the approved order in Docket 775-2022 through April 9,

2023. The well was removed from the approved extension order in Docket 425-2023 good through

October 7, 2023. SWP had to emergency flare a cumulative volume of 14,957 Mcf in July, August and September 2023 due to upset operational conditions in the field. The well experienced a paraffin plugged flowline in July and August. After removing the restriction in the flowline, the well had to be flared to drop the tubing pressure prior to turning the gas back to the processing plant safely. The reasoning for flaring in September was due to the well being

down for a heater treater repair. After the repairs were complete and the well was returned

to production, the well had to be flared to drop the tubing pressure prior to turning the gas

back to the processing plant safely.

GLA

Another SINT (‘Systematic Internaliser’ – II, Bank, Hedge Fund, etc., between clients) trade …

2023-10-05T14:09:57+01:00 GBp 1.614 25000000 40,250,000 Off-book SINT

I suppose this will lower the VWAP? Not that that’s relevant of course.

GLA

MIC code ‘SINT’ trade …

2023-10-04T13:57:30+01:00 GBp 2 10000000 20,000,000 Off-book SINT

So II (‘Systematic Internaliser’) trading on own account between clients. Closed ‘market place’, no MM’s.

Make of that what you will.

GLA