RE: Article on AI precision dosing tech11 Jan 2025 14:32
Population PK/PD modeling, the central methodology of pharmacometrics and the backbone of TDM-based precision dosing solutions, estimates drug exposure and efficacy over time in patients at the population level, or rather how the average patient responds to the drug. This approach allows for parameters associated with a drug to be quantified (e.g., clearance and volume of distribution), describes interindividual variability in drug PK/PD, and identifies predictive covariates. Another component of the pharmacometrics paradigm includes performing simulations to evaluate target attainment at given doses. Comparatively, ML focuses on making the most accurate predictions of outcomes. Although population PK/PD modeling can be considered a form of ML, a distinction between the 2 lies in the types of models used. The population PK/PD modeling approach commonly relies on developing structural models based on PK/PD concepts to provide pharmacologically and physiologically reasonable parameter estimations, whereas ML focuses on minimizing the prediction error using the most applicable model.