Member Info for Lakshmi888

One other thing for those wishing to learn abt pharma and which may stand you all in good stead in the future is to be aware that not only are there different stages of a Clinical Trail ie CT0 to CT4 but there are also different types of trials. The gold standard is a RCT ie a double randomised, controlled, blind trial for those investing or looking into pharmas in the future. It may be useful to look into which type of trial a company is conducting as a higher level of credibility will be associated with positive results/outcomes if an RCT is conducted c.f. with say an observational or cohort study etc�.. �The randomised controlled trial and, especially, systematic reviews of several of these trials are traditionally the gold standards for judging the benefits of treatments, mainly because it is conceptually easier to attribute any observed effect to the treatments being compared. The role of non-randomised (observational) studies in evaluating treatments is contentious: deliberate choice of the treatment for each person implies that observed outcomes may be caused by differences among people being given the two treatments, rather than the treatments alone. Unrecognised confounding factors can always interfere with attempts to correct for identified differences between groups� Sorry for boring you all with facts, lol, but I was asked these questions directly;) I know many of you wld prefer sp levels of double figures to be posted instead....

So, the answer is simple as to why *any* drug (keeping this general rather than FARN specific in order to be objective) can pass CT2 but fail at CT3. Each stage has different objectives & measureable outcomes, and with each stage comes a higher level of scrutiny & also importantly a larger number of patients such that outcomes are much more accurate & representative than they are in the preceding CT stages where lesser no. of patients are involved & the outcomes measured & monitored to a lower degree. Phase 2 is to **establish** the measureable outcomes whereas phase 3 **confirms** the outcomes more accurately due to the larger representative sample of patients involved. In effect CT2 does not effectively measure the therapeutic effect whereas CT3 does. That is why a significant % of compounds fail at CT3. Unfort�y, CT3 is normally the most costly & lengthy stage of any drug�s development which is why there is so much pressure on companies for their compounds to succeed. If they fail for blue chips, you can be assured, it is high impact news globally in the pharma world because of the huge ���/$$$ involved both to the actual failed company and also to their competitors (relief for them as their revenues will not be adversely impacted upon!). It can literally cost millions in CT losses and billions in terms of losses re. potential future revenue. Pharma companies need pipelines and unless the pipeline of *any* part'r pahrma company is strong and I have no reason to believe it is here (happy to be corrected if anyone wishes to) then I cannot imagine the outcomes to be all that favourable esp w.r.t. sp levels .... I�m not certain why Japan producing more favourable data wld have a long term favourable effect as FARN wld still need to justify the legitimacy and credibility of any outcomes to the EMA and FDA of this trial. Indeed, my thoughts are that CT3 would perhaps need to be repeated at best. What are the cost and time implications for FARN if that is required? IMHO, very high��

Rather than having meaningless debates abt sp, how abt a little factual info- no doubt unappreciated by the rampers / those disproving of my presence (lol) here just b/c I disagree with double figure and esp �25 claims, but hey ho!! A few of you, including Wideyed asked me directly (sorry I overlooked it on Fri!), queried why FARN�s drug passed CT 1 and 2 yet failed CT3. Before I answer that it wld be useful to know the following if investing in **any** pharma company imho: *Phase 0: Concerned with measuring the pharmokinetics (effects of body on the drug) & pharmacodynamics (effects of drug on body). Measure �absorption, distribution, metabolisation�. 10-15 people only thus not very accurate *Phase 1: Primary objective to test for safety and dosage mainly, and any side effects though not all may manifest themselves at this stage nor are they expected to. Normally involves 20-100 people *Phase 2: Primary objective to determine(any) efficacy of the drug and further test the safety where less common side effects can be investigated ; often tested against a placebo Normally involves 100-300 people *Phase 3: Primary objectives to *confirm* efficacy, safety *and* evaluate effectiveness. Often compared with existing treatments (if any). Side effects which have been established in CT1 & 2 are monitored at this level. Normally involves 1000-3000 people *Phase 4: Post marketing surveillance measuring safety e.g risks, benefits and optima application. Ongoing throughout the lifetime of a drug following appt. approval eg FDA/ EMA etc.

Hi! Yes, Im well thanks. Hope e'thing is well for you too. Say Hi to......and give him a hug from me! :) ''ATB'' ;)

Of course you wld prefer that Faze as you cld then ramp away (without any success so far itw ld appear), and indeed I was 'egged on' as they cldnt believe what they were reading, nor me! I've not deramped but provided my viewpoint based on facts. Can the same be said of the rampers??.....:) Just so happens, my viewpoint doesnt see FARN hitting �25 or even double figures any time soon. Is that classified as deramping?? :)

out in full force yet again, lol! ;) Failed last week. Increase of approx 15% so far. Surely, if you have no confidence in PANR and have thus sold out, better to invest both your time and �� elsewhere? E'thing you are stating yet again is pure speculation / supposition....nothing to factually back up your claims..... Let the RNS's and the sp speak for themselves.... I'll wait for the next RNS and continue to assess accordingly. Excuse me if I pay no attention to your unsupported claims of placing, shorts, lack of $$$, attempts to get pis sucked in etc. Happy to see any evidence if you have any though ....and I mean that sincerely!! Until then, GL all genuine holders:)

I didnt post last night as it was all in bits and I didnt spend most of my w/e ramping or deramping a share. I dont need to!! I'd rather not post scraps and unsubstantiated claims unlike many on here! I leave you guys to that. Still to see anything credible on here supporting claims of double figures let alone �25. Strange how defensive the rampers get when alternative opinions are proposed. I guss you wld all prefer a bb with everyone saying this is going to �15.00, �20.00, �25.00..........;)

http://www.lse.co.uk/share-regulatory-news.asp?shareprice=NTOG&ArticleCode=ya6o7629&ArticleHeadline=Award_of_Share_Options

Kindly posted by Ros on Twitter. Many Thanks :) https://twitter.com/rosolanor/status/1003377324996333568 Let's see how she goes....

Kindly posted by Ros on Twitter. Many Thanks :) https://twitter.com/rosolanor/status/1003377324996333568 Let's see....

Hi Fix. Yes, RNS was required and hey presto, it lands! Shd put to rest (for a few hrs at least!) all the nonsense/supposition/rumours posted since Fri and over the w/e. Still, next RNS will be significant so will wait until then and hope sp begins to moves north!! Was kindly provided with a chart from Ros which reinforced my thoughts..... #FeetOnTheGround Hope all is well with you.

Morning Flockton. NP :) Too many derampers out in full force last week, sp dropping, negative chartists, non-holders slating, TW getting involved (jeeeez!!). So, I figured s'thing good was coming (!), sat tight and topped up more on Friday hehe! Only an RNS will provide the facts. Saw all the posts last night from the w/e and thought 'good grief'!! AIM is based to a large degree on sentiment. Dont let the doom-mongers get to you! Let's see what the next RNS brings but today's RNS has quite a few positive pointers and info relating on PANR moving forward. Nice to see. GLA:)

Just. Ignore.The. Noise!! There will always be the doom-mongers, the trolls, the rumour-based clowns., the supposed know-it-alls......... Ignore. Wait for official news and sit tight until then. #Patience! Nice RNS. GLA :D

''....analysis concludes that the Eagle Ford sandstone in our West AA prospect is not water saturated, and that the water has likely been introduced from a source below the perforations as a result of the frac. The analysis of the VOBM#5 and other Polk County wells was a very comprehensive undertaking, involving extensive analysis of regional data which took considerable time to complete. The analysis also concluded that 100% of the perforated intervals in our wells were in fact hydrocarbon bearing pay zones and following this analysis the consulting geologist Art Berman has confirmed his assessment of potential P50 Prospective Resource of our project has not changed, remaining at 301mmboe''. Nice:)

http://www.lse.co.uk/share-regulatory-news.asp?shareprice=SDX&ArticleCode=2gxdtr4b&ArticleHeadline=Spud_of_SD-4X_appraisal_well,_Egypt&ahc=miw8zi3a

Update on Gas Discovery http://www.lse.co.uk/share-regulatory-news.asp?shareprice=MYN&ArticleCode=o6r5o5d1&ArticleHeadline=Update_on_Gas_Discovery_at_Stockdale_Field,_Texas&ahc=e2ja8iv6

http://www.lse.co.uk/share-regulatory-news.asp?shareprice=HNR&ArticleCode=k04r4paj&ArticleHeadline=Colorado_shale_projects_update&ahc=zqrlsz6q

All happening today!! :) Goodn news just keeps onc oming with SEE! http://www.lse.co.uk/share-regulatory-news.asp?shareprice=SEE&ArticleCode=jo2khzgj&ArticleHeadline=Automotive_design_win_with_US_OEM_for_FOVIO_chip&ahc=6f9pfk8z Automotive design win with US OEM for FOVIO chip

http://www.lse.co.uk/share-regulatory-news.asp?shareprice=PANR&ArticleCode=48lxf6tc&ArticleHeadline=Operational_Update ''The results of the analysis concluded that the large volume of produced water in the VOBM#5 well is not believed to be sourced from the perforated intervals in the targeted Eagle Ford sandstone, and is more likely a result of frac operations communicating with a deeper water source below the perforations'' ''Pantheon confirms that the operator has identified two appropriate drill rigs for the planned sidetrack of the VOBM#1 well. Discussions are presently underway and aim (subject to contracts and scheduling) for spudding as early as late July. The original VOBM#1 well was tested at 1,500 boepd on a 12/64th inch choke before production was subsequently impacted by collapsed casing. The VOBM#1 sidetrack is considered to have a high probability of success by the operator. Pantheon also confirms that in Tyler County, negotiations are in late stages for the processing and transportation of natural gas for the VOS#1 and future Tyler County operations.'' GL all genuine holders:)

As saidn yday, wait for the RNS's and ignore all the noise!! ''Pantheon confirms that the operator has identified two appropriate drill rigs for the planned sidetrack of the VOBM#1 well. Discussions are presently underway and aim (subject to contracts and scheduling) for spudding as early as late July. The original VOBM#1 well was tested at 1,500 boepd on a 12/64th inch choke before production was subsequently impacted by collapsed casing. The VOBM#1 sidetrack is considered to have a high probability of success by the operator. Pantheon also confirms that in Tyler County, negotiations are in late stages for the processing and transportation of natural gas for the VOS#1 and future Tyler County operations.'' GL all genuine holders:)