RE: Super Mutant Botswana Variant25 Nov 2021 22:42
Jeffery Barrett .
"Finally S477N and Q498R, predicted in an experimental evolution paper to substantially increase ACE2 binding together with N501Y, but only seen in the wild separately or rarely. Seeing this full combination now (along with everything else) is grim."
Jeffrey Barrett is the chief scientific officer @ Nightingale Health, also leading the Covid-19 genomics initiative @sangerinstitute