The positive science clue hidden in the RNSToday 09:5928 Mar 2024 10:45
Hotblack Desiato earlier today.
If I've read things right then 1801 may well be at least equal to Sotyktu, possibly even better.
The RNS noted, "...interim data shows that levels of SDC-1801 in blood are already in the expected therapeutic range, and achieve concentrations greater than those predicted to reduce signalling of cytokines dependent on TYK2 and/or JAK1 activity by 50% for a sustained period following once daily oral dosing."
So what this suggests is akin to a high jumper being able to clear the bar with room to spare. What remains to be seen is just how much higher can 1801 jump?
Sotyktu achieves a reduction of IL-17A, IL-19 and beta-defensin by 47% to 50%, 72%, and 81% to 84% respectively following 16 weeks of once-daily treatment (link below). 1801 appears to be in the 50%+ club so it's all still to play for.
https://www.sotyktuhcp.com/mechanism-of-action
Regards.