Member Info for inanaco

Lindy was comparing Moditope as well ... because she states "30 years" .... as moditope was discovered approx 2012 clearly she has considered all research

only to you .........

Genentech and BioNtech don't agree with you

the issue is Ruckrovers first post

Unless you have seen ALL the data, from EVERY other trial AND are qualified to interpret it, your statement above is at best meaningless and at worst laughable!

"" there is no need to take personal offence or question the integrity of the poster"""

By over stating Project fear those that are responsible draw that criticism on themselves

why they have not done a deal yet is an unknown which you can speculate on

what you cannot speculate on is a science problem that exists that we have not identified

which is why i asked the question "what mechanism would thwart synergy"

Now Scancell may consider what has been offered is not good enough and because we are still testing how far we can push SCIB1 it would be unfair to say that Scancell does not have the commercial nouse to close a deal. When they have previous experience of selling MABs to other parties (£5m)

with all of BioNtech and Genentech sequencing of patients cancers over the last few years in the search for neo epitopes

why is it they have not found anything that would suggest an alternative patentable suite of epitopes that is comparable with Moditope.

If one did exist why have the Top "Car T" and "TCR" not found it or licensed it ?

so Ruckrover by "creating competition" that as yet does not exist, finds that the industry has not found it either

all that money compared to Ruckrovers budget

the point of the pfizer post rhatton is that pfizer will invest $120m into one vaccine which does not exist yet draws attention to Scancell SP which has a suite of vaccines that do exist and one has been through trial yet the Mcap would not even cover the development value placed on one vaccine by BioNtech

to late then to buy in at this level, which is the point of why we are here, if we have evaluated scancell correctly then the reward will be enormous ...

Sales of anticoagulant Eliquis grew 37 percent, and sales of immunotherapy drug Opdivo increased 34 percent. Each drug generated $1.51 billion in revenue.

Keytruda had sales of $1.46 billion in the quarter,

correction slightly less

The drug, which is also known as Keytruda, would have cost around £84,000 per patient at its full list price. NHS England and MSD have agreed a confidential arrangement for reimbursement which will enable NICE to recommend it be routinely available on the NHS.

The flu vaccine may be available from pharmacies or in supermarkets. It is provided on a private patient basis and you have to pay. The vaccine costs up to £20.

PD1 costs £100,000 up ....

you would have to sell a lot of shots to equal that cost

BioNTech will receive $120 million in upfront, equity and near-term research payments and up to an additional $305 million in potential development, regulatory and commercial milestone payments. In addition, BioNTech will receive up to double-digit tiered royalty payments associated with worldwide sales if the program reaches commercialization

one vaccine

our Mcap is £50m

when will reality hit home ... risk blah blah blah ....

Ruck post actual data ... ie go an find it, don't just assume its there when to date we have not seen any.

BioNtech has just done a major deal with Pfizer on mrna vaccines for a flu vaccine which i do not see in the pipeline yet, """""" to develop mRNA-based vaccines for prevention of influenza (flu).""""

Now take a look at the calculus presentation and Lindy describes an Mrna vaccine built around personal "neo epitopes" and its success rate so far is about 20% ..

https://youtu.be/CXyPYib5JWc

24.2 mins in

so Pfizer prepared to pay a fortune just to access that Mrna technology on ONE vaccine ...

so what is scancell worth ?

interpret ???

most studies contain a diagram which produces a picture even you can understand of "progression" "responders" etc etc

Clearly you have understood Lindy's graph as its a straight line 100% in the mouse model

so why is it you need a """qualified to interpret""" badge ... ?

because that would Rule out all of Booms, wilds posts as well ....

so really Ruck you are just being a bit silly

its a true statement ...

"i have not seen"

you are now adding "items" that you also have not seen ... thus cannot prove exist

so i assume you mean your post is meaning less as mine is actually factual

"This approval from GTAC and MHRA provides our Investigators with the opportunity to continue dosing patients whose disease has not progressed whilst receiving the SCIB1 vaccine and will allow the Company to gather longer term data on late stage melanoma patients for whom the prognosis is poor."

so this is the Group that we are now targeting with the 8mg dose in combination with a check point inhibitor

I have never seen any pre clinical data that compares with moditope, so i would not worry about competition. We have also seen that vaccine's for cancer are so difficult to get right, many have given up or are reliant on PD1 to give assistance. SCIB1 works as a stand alone, and to the surprise of Lindy had effect on solid tumours, many may have forgot that Scancell got the approval to treat for an extra 5 years because of that phase 1 success in patients that had existing tumour's, again i cannot see any evidence in Scancells data, or in other data that would indicate that the synergy between PD1 and SCIB1 would have flaws. Nobody on here has come up with any sensible suggestion to say it would.

The issue is Boom that a man of your experience had to post this ...

"" Can you confirm that there isn't some as yet, poorly understood immunosuppressive mechanism that could result in patients failing to respond? """

against the back drop of SCIB1 in trial for years and no """ poorly understood immunosuppressive mechanism"" coming to light in over 30 patients ....treated for a very long period

So why do it ? it just was not required

when Scancell has clearly identified the ligand PD1 Turns OFF the high avidity T cells generated by SCIB1

so your desire to push this "risk" profile has actually caught up with you ........ its fake news.

i have no issues with what you post at all, indeed carry on. However if you make a post that to most on here with a bit of understanding Raises Eyebrows why indeed should we be silent ?

its nothing to do with Victory ... i really have no desire at all to push an agenda, other than see a level playing field on what lindy has achieved and try and explain it all as best as i can in layman's terms

If you feel any of my technical posts need "tweaking" then post because that is called reasoning

""" Wild, I would happily allow Inanaco his opinions"""

Really ?

careful of the "death Ray Pointer" tosh is hotw1ings ... testosterone

lol