ray3 Feb 2019 19:30
Antigen response defines the number of responses to any one epitope by any patient against the number of potential responses for the number of patients tested.
Generation of IFNg (A-H) in response to immunization with SCIB1. PBMC were isolated at the indicated study visits and cultured for 10-17 days at 37 C with HLA-A2-restricted TRP-2 peptide or with HLA-A2-restricted, HLA-DR4-restricted or HLA-DR7/DR53/DQ6-restricted gp100 peptides. IFNg was assayed on days 10 and 17 by Elispot following a 24 hour re-stimulation with the appropriate peptide. Data is shown from one timepoint for each patient. Representative Elispot data is shown for patient 04-16 (day 10), a patient with tumor present at screening and receiving 4 mg doses of SCIB1 (A); three patients with tumor present at screening and receiving 8 mg doses of SCIB1 (01-46 (day 10), 04-27 (day 17) and 04-28 (day 17) in panels B, C and D, respectively); and four fully-resected patients receiving 4 mg doses of SCIB1 (05-09 (day 10), 05-11 (day 10), 05-18 (day 17) and 05-21 (day 10) in panels E, F, G and H, respectively). The results shown are the mean number of IFNg producing cells § standard deviation (n D 4). Study visit days in the main study are denoted by the prefix "D" and in the continuation phase by "C" where Cx0y indicates x D weeks after dosing and y D continuation dose number. (I) Maximum mean of four wells IFNg spot count for individual antigens determined for each responder. Non-parametric statistics (Mann Whitney test) were used for comparison of the results between cohorts. Antigen response defines the number of responses to any one epitope by any patient against the number of potential responses for the number of patients tested. (J) Administration of >10 doses of SCIB1 conveys a broader range of epitope recognition in fully-resected 4 mg patients compared to five administrations. The bar represents the median antigen recognition; the P value was calculated by the Mann Witney test. Individual colours represent individual patients i.e. 05-11 (black), 05-24 (red), 01-32 (blue), 05-19 (yellow), 05-21 (green) and 05-18 (purple).
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