This explains why the Right8 Feb 2019 20:00
Vaccine is so important.......
T cells, which are immune cells crucial for rejecting tumors, use their TCRs to recognize short antigenic peptides bound to MHC-I and -II molecules on the surface of host APCs. Naive T cells that have never been activated by antigen are initially triggered by TCR recognition of specific peptide/MHC complexes presented by dendritic cells, which are specialized, professional APCs that provide additional potent costimulatory signals for T cell activation. Dendritic cells capture exogenous antigens from pathogens as well as from host cells. The ability of dendritic cells to take up and present antigens is the basis for vaccination’s ability to produce T cell immunity. Activated T cells can go on to destroy antigen-positive host cells, e.g., cells infected with pathogens or cancer cells. Host cells, including cancer cells, can serve as targets for previously activated T cells through the processing and presentation of antigenic peptides.
"""""" However, nonprofessional APCs, including most cancer cells, which lack costimulatory molecules, are ill-equipped to initiate immune responses from naive T cells. """"""
which is why Scancell specifically target Professional Dendritic cells by cross presentation and the correct cytokine
which is why you get a detectable Immune response ..
This is a FACT and has been proven in Trial . it's nothing to do with patients numbers you cannot falsify this data
By definition, T cells with high functional avidity respond in in vitro tests to very low antigen doses, while T cells of lower functional avidity require higher amounts of antigen before they mount an immune response similar to that of high-avidity T cells.
https://www.hindawi.com/journals/jir/2012/153863/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC503781/
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