Member Info for inanaco

the UK = 19 of the smaller EU states combined
UK has a global reach not just EU trade
UK can set its own trade policy

the only value the EU brings is the single market ... but you are subsidizing poor EU states and because of the wealth gap encouraging wealth harmonization .. which as Greece found out ... is not that easy ..
so we are importing low cost labour which has a direct cost on productivity here ... ie you don't need so many Robots you can employ migrants ...

that low cost labour does not pay much tax ... yet expect full social welfare ....

5m !! how many extra hospitals schools and houses ?

How many super Rich .. are using freedom of movement .. ? to get suckered into our tax system ?

Labours policy up to today was to Leave with a deal in name only ............. ie stuck in a customs union and the single market without a say

now it wants a ref ............... on its deal "stuck in without a say" or stuck in with a say " (remain)

some offer that is ....

Lib Dems = revoke

Today Conservatives and Brexit party, a deal that removes us from all EU institutions .. as per the Ref.

Mays deal was half in half out ............ actually about the same as Corbyns .... because the back stop guarantees in law that we would be forced into a customs union/single market deal .

hence She got the Sack ...

well i will leave the Remain campaign who do not yet have a platform to secure a vote to remain ....

Boris is still in power ... despite asking for an election ..

you watch to much BBC ... who is scared ?? oh yea remoaners

ask 17.4 million ...... they don't want to be ruled and controlled by the EU

you cannot keep fighting an argument that you have already lost ......

a Second ref failed ...

Parliament does not know what it wants ...

that is your problem ......... the electorate are not so stupid

MEP

15 libdem

26 brexit party ..

delusional ...

Just remind you Brexit won ....

you act like remain won

We built an empire without the EU ........... we Lost it defending Europe ...

the question is not a second ref ...

the argument is, would you rejoin after we left ?

Parliament can still revoke today ........... it could have done that rather than use its power to force Boris to extend

what will you do in this extension ?

if Remain was so high up in the pecking order of the electorate why did Brexit party win so many seats ?

then why is Germany close to a recession ? why is the ECB still pumping billions into bond purchases ? you cannot just keep blaming Brexit for poor management considering they have had 3 years to change business practice ... markets slow for all sorts of reasons .. you could actually put more weight on Greta Thunberg and climate change

the currency has been pretty stable since 2016 ref .................... and indeed the German side of the business is in Euro off setting £ .. Euro fluctuations

What we put into the EU we got back (well 95% of it)

your having a laugh ........In 2018 the UK made an estimated gross contribution (after the rebate) of £13.2 billion. The UK received £4.3 billion of public sector receipts from the EU, so the UK's net public sector contribution to the EU was an estimated £8.9 billion.

that's a lots of Researchers ? 95% of £8.9 billion ..................

I assume your a liberal Democratic and believe you will revoke !! while 17.4 million are dead in a ditch and will let you ..

point being Mabs that "block" an action like PD-1 .. to invigorate a T cell would not really be suitable to add cytotoxicity to Kill the T cell .. better Binding ? well that could only be tested by actual building a Keytruda clone with high avidity ... and testing against the original ... so ... scope as ever but it all revolves around a lot of work ..

or visit Loz ... ranting on his terrace ..

March 2019 .... read the conclusions ...

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00594/full

Tf if you attempt a like for like comparison you would at least need all the research papers and pre-clinical data, on all BioNtechs programs which unlike Scancell don't appear to be well displayed on the websites ..
This is not to say that MRNA is more effective than say DNA vaccines because they have collaboration ..

because to be honest Scancells skill is superior in understanding "Binding" which is why Immunobody instructs DC's to generate High Avidity Binding, Avidmab generates High avidity binding ... whats interesting is moditope because that binding spontaneously generates high avidity T cells they go nuts ... "they differentiate" which is why moditope is so fascinating

MRNA technically is more versatile in that you can make cells become factories ... but the MRNA v DNA vaccine approach ..

would require a Like for Like proof of concept pre-clinical test ...

https://clinicaltrials.gov/ct2/show/NCT02410733 ............ that would be an interesting trial to look at

https://www.curemelanoma.org/blog/article/melanoma-vaccines-show-promise

Bang on bermuda ... !! second that ..

Because BioNtech are so science orientated like scancell with the top management dedicated and indeed have invested very very heavily in the ability to build personal vaccines .. and in automation of the supply chain with siemens
https://new.siemens.com/global/en/markets/pharma-industry/references/biontech.html

this will apply equally to TCR its all about speed from blood collection to implanting the Lenti-viral into patient t cells and clonal expansion to re infuse

so there is an awful lot of planning involved to get the through put needed to start a trial ...

so BioNtech must be committed once they know the "efficacy" of the moditope created T cell .. how they are testing that in a mouse or human blood model is unknown, and these are the sort of questions that should have occupied the 20 mins slot instead of the garbage of why we didn't get a deal back in 2015 ... we are where we are and LTH need to get over it ... and just look at the sheer amount of IP generated since that has not been valued yet by the market ..... shortsighted share holders should attend spec savers .

now the next bit, which refers to my post on building the inhouse skills to add value to the epitopes that could be licensed

""" Building internal expertise in TCR identification""
(BioNTech collaboration)

most important bit, which is what my correspondence with Lindy elucidated to ...

""Lenti-viral transduction of T cells now working in the lab""

"""We pre-activated and differentiate the CD4 T cells before we transduce them with the Moditope TCR.
Kind Regards,"""

30,000 had not noticed Cheers ! C7