Member Info for HelloSanDiego

Professional - "I have shared my ideas about a TO in February. "

I haven't seen them, but I've mentioned the possibility of it on here a few times. I had been hoping someone could offer a reason why it was impossible. But as things stand I think it's just very unlikely. Any developments with STRIVE will lead me to reconsider it though.

Professional - "why are you all not more demanding with regard to RM and happy with him smiling at agm and other occasions?"

You're better off asking Polygon. They've thrown a lot more money into this than any of us.

Professional - "You cant fault mr Costs logic."

I can. He keeps coming back here to complain when it's the one place where everyone knows as much as he does about the firm, and therefore couldn't care less about his opinion.

Costs - "18p........... The placement was £1.75."

The share price was 6p at the start of 2020. Things change. It's great you keep coming back here to whine though.

MrCosts - "7 trades today, my local corner shop has done more trades selling milk."

I'm not too interested whether or not traders see this as an easy opportunity to make a few pence.

That won't happen. They've stated the selection criteria. So if we're not selected, the official reason will be that it didn't match the selection criteria as closely as those that were selected.

Doc83 - "I’d still say that was open to interpretation."

The good news I was referring to was when she said "Further agents are in process for STRIVE; however, I am not able to discuss what these agents are".

I'm pretty certain that means our chances of SNG being included is considerably higher than it was at the start of the week. And as I said on Monday, after seeing the STRIVE selection criteria I was sceptical we were at the top of the list but very confident of being in the top few.

Successful traders know better than to think that posting rubbish on here could provoke enough trades to make it worth their while.

I think it's more likely they're just former/current investors who lost money here and want to vent their anger.

I was writing that question while Paladin was answering, btw.

Has anyone worked out why the trolls turned up today? I mean, we just got the best news we've got in over a year and suddenly several pop up at once.

I didn't say it was a no brainer and I'm not trying to encourage anyone to buy, sell or hold.

But I have no doubt the email was genuine and if you want to argue that it isn't really great news they're adding at least another two drugs to a large, NIH funded phase 3 trial, you go ahead.

That's a good question, Professional. I'm glad you asked.

I'll just write out a detailed answer, get it proofread and signed off by my legal team and get back to you asap. You just wait there ok?

Viletrader - "Exciting news for 'emotionally distressed' investors only."

I think you missed the email saying they are in the process of adding multiple new drugs to STRIVE. I suspect that's why traders aren't selling today and buyers have yet to catch on.

I see. I thought that would be the case because it seems logical. But I thought it was worth getting confirmation.

Possibly a data protection thing. Might also explain why Brooke didn't offer a reply.

Thanks for replying.

I should have explained that I was asking about a specific drug and trial protocol. Its trial from last year make me think it should meet its secondary endpoints on an upcoming trial (lower mortality and less chance of needing mechanical ventilation) but it might struggle with the primary endpoint (time to recovery).

So I intended it as a technical question about the regulatory process, i.e. "Does missing the primary endpoint always guarantee it's refused approval even if it meets the the secondary endpoints and demonstrates it can save lives?".

It's Synairgen's antiviral drug SNG001 by the way, in case you're wondering.

The answer Richard gave was tens of thousands of active treatment and placebo.

But even if they have enough for ten large trials, the doctors running STRIVE will need to know they have their supplies agreed by the company and reserved prior to submitting the application for the trial to the FDA.

I'm pretty sure we only have enough for one large trial.

So the doctors running STRIVE will need to know it's there when they need it. That means getting the company to reserve it, which means letting them know well in advance, i.e. before submitting the application to the FDA.

If they plan to start it within two months, they will need to know now that stocks of the drug will definitely be available. I'm sure that must mean the company would already know.

Manifest - "Would we all agree that RM knows if we are on the list or not?"

He must do. They would have to consider product availability and reserve it well in advance, for one thing. It might even explain the QA job that was posted on the website six weeks ago.