RE: Faron -ifn b1a----worth reading4 Jul 2020 17:20
Severely ill COVID-19 patients with increased levels of plasma cytokines (especially IL-6) show signs of immune exhaustion and poor IFN responses [13]. Even in such cases, these patients would most likely benefit from IFN-beta, because it is the most potent anti-viral and anti-inflammatory agent of all interferons. It can induce the desired immune boost, but simultaneously downregulate IL-6 and IL-8 [14] and impair extravasation of neutrophils into lungs [15].
Conclusions
IFN-beta is now among the leading candidates to treat COVID-19 in various clinical trials, and i.v. and s.c. routes of administration are considered to be equal. This is not the case due to the different bioavailabilities of IFN-beta via i.v. and s.c. injections in target organs. This aspect needs to be taken seriously, when critically ill patients with compromised peripheral circulation are treated.
I like these end bits