Ryan Mee, CEO of Fulcrum Metals, reviews FY23 and progress on the Gold Tailings Hub in Canada. Watch the video here.
On website https://avacta.com/research-and-development-spotlight-series-episode-1/
Fyi " In the new R&D Spotlight Series we will take you a little deeper into the science behind the Avacta Therapeutics pipeline. In the first episode today we're going to introduce you to two of our key chemists who are working on the preCISION platform. https://avacta.wistia.com/medias/1h18nhz59w #AVCT"
Fyi Dr Tap comments
Dr William Tap, Chief, Sarcoma Medical Oncology at Memorial Sloan Kettering Cancer Center, NY also commented:
“These initial clinical data are encouraging and demonstrate that the novel drug delivery mechanism of AVA6000 has the potential to demonstrate single agent activity in patients with solid tumours that express high levels of FAP. The safety data when compared with standard doxorubicin are highly encouraging and demonstrate the power of the pre|CISION™ platform to avoid normal tissue effects while concentrating the toxin in the tumour microenvironment.”
-----------------------
"Avacta is pleased to provide detailed pre-clinical, clinical and pharmacokinetic data from the Phase 1a dose escalation study of its lead pre|CISION programme, AVA6000, a tumour activated form of doxorubicin.
https://avacta.com/als-6000-101-phase-1a-three-weekly-dose-escalation-safety-study-data/ #AVCT
Hi GoSushi : Simply put by MSK Investigator William D. Tap video clip .
https://twitter.com/tom_the_bomb__/status/1768724336603439298
https://www.mskcc.org/cancer-care/clinical-trials/22-428
"First-line treatment is usually the standard treatment (the "gold standard") given when someone is diagnosed with a particular disease or condition"
Thought worth sharing had confirmation from Avacta CEO today about the possibilty of selecting first line patients " in the ongoing two-weekly dose escalation study"
---- "Yes, they could be first line. Obviously depends entirely on the clinician treating them etc. but we are able to be more selective now given the great data to date."
Good luck everyone
Yes thanks for sharing Mr M - LeakBot simple solution that works good business model - seems win/win for everyone involved . Increasing recurring reveneus and asset IP protected . Ondo also doing it's bit for reducing water waste .
"Ondo InsurTech Plc
https://twitter.com/OndoPlc/status/1771119814955634970
@OndoPlc
#ONDO proud to support #WorldWaterDay. We are helping by fixing 1 leaky loo at a time. Leaky loos waste 200-400 litres per day and 8% of UK toilets are leaking.
We find them with our unique
@Leakbot_HQ
tech and we fix them - proud to do a little bit to help a precious resource go a bit further #GreenEconomyMark"
Good Morning informative RNS
"The Value of Understanding IP For an Investor"
"IP Value
Intellectual property value does indeed have financial value. And that's why companies need to evaluate it regularly to ensure they are not leaving money on the table. A company that regularly updates the market on its latest developments and progress is building a public record of its IP growth.
For investors in micro, small, and mid-cap companies, monitoring IP growth can help them spot early investment opportunities and bargain stocks. That's why IP valuation is an important stock investment tool.
When a company spends time building a brand and innovating its suite of products and services, the value of its IP assets fluctuates. But a company that pays heed to its IP and regularly releases news flow to showcase the breadth of its intellectual property could help increase brand awareness and overall market value."
Hopefully the start of some Avacta boosting . -
So what is more important ? - the current SP OR company protecting , keeping inhouse its " two proprietary platforms" – " Affimer® biotherapeutics" and key asset " the pre|CISIONTM tumour targeted chemotherapy"
Anyway not all about the SP - Avacta IP asset rights matter :
https://www.valuethemarkets.com/analysis/the-value-of-understanding-ip-for-an-investor
P.S, Back to watching, listening & waiting . good luck everyone .
Did not win but still good press for ONDO
https://www.plc-awards.co.uk/
https://twitter.com/foster_ideas
"Craig Foster
@foster_ideas
·
26m
Thank you
@PLC_Awards
for a great night and to Economic secretary
@BimAfolami
for an entertaining speech. Congrats to
@_CapitalLimited
who beat #ONDO for the Breakthrough of The Year Award - a great accolade for
@OndoPlc
to be shortlisted! #GreenEconomyMark #InsurTech
Quote
plc awards 2023
@PLC_Awards
·
Mar 6
We are delighted to welcome the Economic Secretary to the Treasury @BimAfolami to the @PLC_Awards on 14th March 2024. The Minister will deliver a keynote speech following the release of the Spring Budget today. For further information on the awards go to https://bit.ly/3wxxe"
Be good to get an update from Craig business trip to meet USA customers . MOE pilot seems to be going well .
"LeakBot Water Detection Pilot Program Launched in Washington State Enumclaw, Washington – October 3, 2023
Mutual of Enumclaw members with homeowner’s insurance coverage in Washington State, the LeakBot water detection device monitors a home’s water plumbing system 24 hours-a-day, sending alerts that deftly guide users through next steps when leaks are detected."
“At Mutual of Enumclaw we’re committed to serving our members’ best interests—and protecting their safety is at the center of who we are as a company,” said Mutual of Enumclaw Chief Underwriting Officer Jerel Titus. “Non-weather water events caused by damaged pipes, worn out seals, cracked hoses and more not only endanger our members' health but also their homes and their wallets. We love that LeakBot’s innovative leak detection and prevention technology, overall effectiveness, and ease of use provide an extra layer of protection for our valued members.”
Protection for Members
As the number one cause of damage in homes, more than one trillion gallons of clean water are wasted every year in the United States due to water leaks. The new LeakBot service allows Mutual of Enumclaw to continue providing needed coverage at an affordable cost while also helping to protect the planet’s resources.
Compatible with both Android and iOS operating systems, LeakBot works by accurately measuring air and pipe temperatures in a home. Because leaks continually draw colder water from outside—creating a prolonged, consistent drop in temperature—LeakBot alerts homeowners when sensing a problem, whether they are at home, at work or even on vacation.
Members who choose to participate in the voluntary pilot program need only follow a few simple steps to easily-install the device and mobile application with no tools or plumbing know-how. In return they receive complimentary risk mitigation services that include 24/7 monitoring and on-site repair service from LeakBot’s highly-skilled, experienced plumbers the event that a leak is detected.
The majority of claims are small, hidden leaks that cause damage over a period of time. As part of the program, Mutual of Enumclaw not only covers the cost of the device and water usage monitoring, but also the mobile application and any visits from LeakBot plumbers needed to fix leaks including parts and labor required to make a property leak-free. "
https://mutualofenumclaw.com/helpful-resources/member-information/mutual-of-enumclaw-launches-new-leakbot-water-detection-pilot-program
Fyi "Craig Foster
@foster_ideas
Yesterday was Nationwide in Des Moines, today we started our New York-Connecticut-Massachusetts road trip - schedule is killer, great to pack so much in #ONDO
https://twitter.com/foster_ideas/status/1765476315015098680
Hi jabberba . Might mean they are very happy with the early trial results for LeakBot . Financial savings already been seen by MOE insurance company due to early detection of customer water leaks . Or something like that .
"What is a Wrap Report?
A wrap report is a low-cost annual report, which is a public company's Form 10-K with an annual report cover wrapped around it. A small amount of additional commentary may be added by management. The cost is kept low by avoiding the use of graphics or color, and by minimizing the page count.
A wrap report is usually issued when a business does not want to spend an excessive amount on an annual report, and especially when little attention is being given to investor relations. The issuer of such a report tends to be a smaller public company. Larger entities are usually willing to allocate substantially more money to the production of a more lavish annual report."
Good evening.
Proxy : voted FOR the resolution . Did not particpate in Rex offer have more than enough in my investment holding.
Still firmly believe Avacta will eventually deliver shareholder value , with funding secured hopefully see better execution & communication going forward . Not really sure anything new will come out of the" general meeting of the Company expected to be convened on 18 March 2024; "
Time will tell whether my faith in Avacta science is warranted . The message board at the moment not a great read , so will stop posting & not bother sharing links . Will return when back in paper profit " SP 119.2349p breakeven " Unlikely be days , slim chance weeks. , very good possibility months ,if years be a very long wait so hopefully well before July 2026 end target date .
Best of luck genuine LTH shareholders
--------
"In parallel, start selling DX and further enhance cash runway to be armed against any further possible delays."
Wonder what LD & Coris staff think about Avacta parent company.
Anyway they do seem to have a wide range of diagnostics products to sell .
--------------------
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Have no issue with folks expressing disappointment at the placing price and the way it happened , causing many shareholders £ investment take a dramatic paper hit ( mine included ).
Yes folks want answers why , fair enough , CEO did say :
"Alastair Smith, Chief Executive Officer of Avacta Group plc, commented:
"Under very challenging market conditions we have raised financing that allows Avacta to progress at full speed its lead pre|CISION? targeted chemotherapy, AVA6000, into the expansion and Phase 2 efficacy studies. The emerging clinical data from the Phase 1 safety study strongly supports our belief that pre|CISION? can change the way in which cancer is treated and we are pleased that we are now in a position to also progress the broader pre|CISION? pipeline.
"Critically, this financing provides Avacta with 24 months of cash runway to focus on advancing AVA6000 through the clinic, as well as progressing other assets earlier in the development cycle to hit key commercial milestones."
Anyway leave the conjecture to others , hopefully will eventually turn out alright in the end for everyone involved . Would like to think many still here wish to see Avacta science succeed and that still remains the ultimate goal .
Good luck
Good Morning
Note Dr Tap likes this research .
https://twitter.com/everettmoding/status/1763603975281254437
"William Tap reposted
Everett Moding, MD, PhD
@everettmoding
Thrilled to share our latest study in
@NatureCancer
investigating the diverse malignant and stromal cell states that make up soft tissue #sarcomas (STS) and their associations with patient outcomes and response to treatment!"
Needs to say i like this opinion .
FYI https://theoakbloke.substack.com/p/avct-avacta-avacta-cash-burn-factor?utm_source=profile&utm_medium=reader2