Asim duttaroy8 Dec 2020 12:05
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review
https://www.facebook.com/asimkduttaroy/posts/2761689037426955
https://www.preprints.org/manuscript/202012.0136/v1?fbclid=IwAR3L5nhYC9aBbjShUYjUKjei8_pjcDpxzWIawyLxJnwbFw8WkxstiYQt98M
https://www.preprints.org/manuscript/202012.0136/v1/download
"Abstract
Emerging data have demonstrated a strong association between the gut microbiota and
the development of cardiovascular disease (CVD) risk factors such as atherosclerosis,
inflammation, obesity, insulin resistance, platelet hyperactivity, and plasma lipid abnormalities.
Several studies in humans and animal models have demonstrated an association between gut
microbial metabolites, such as trimethylamine-N-oxide (TMAO), short-chain fatty acids, and
bile acid metabolites, amino acid breakdown products, with CVD. Human blood platelets are a
critical contributor to the hemostatic process. Besides, these blood cells play a crucial role in
developing atherosclerosis and, finally, contribute to cardiac events. Since the TMAO, and
other metabolites of the gut microbiota, are associated with platelet hyperactivity, lipid
disorders, and oxidative stress, the diet-gut microbiota interactions have become an important
research area in the cardiovascular field. Platelets became hyperactive in people with diabetes
mellitus, sedentary lifestyle, obesity, and insulin resistance and exhibited increased sensitivity
at a baseline level and in response to agonists, ultimately contributing to increased aggregation
plaque development. In addition to these factors, TMAO also contributes to platelet
hyperactivity. Several approaches are now suggested to reduce plasma TMAO levels, such as
microbiota modulation using probiotics, prebiotics, and oral broad-spectrum antibiotics. This
review describes the association between microbiota-derived metabolites and CVD
development."
Fruitflow mentioned on page 16.
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