Member Info for gixer

Platelet hyperactivity in COVID-19: Can the tomato extract fruitflow® be used as an antiplatelet regime?

Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus is now considered a global public health threat. The primary focus has been on reducing the viral spread and treating respiratory symptoms; as time goes on, the impact of COVID-19 on neurological and haemostatic systems becomes more evident. The clinical data suggest that platelet hyperactivity plays a role in the pathology of COVID-19 from its onset and that platelets may serve critical functions during COVID-19 progression. Hyperactivation of blood platelets and the coagulation system are emerging as important drivers of inflammation and may be linked to the severity of the ‘cytokine storm’ induced in severe cases of COVID-19, in which disseminated intravascular coagulation, and platelet hyperactivity are associated with poor prognosis and increased risk of mortality.

We propose that targeting platelet hyperactivity in the early stages of COVID-19 infection may reduce the immunothrombotic complications of COVID-19 and subdue the systemic inflammatory response. Lowering baseline platelet activity may be of particular importance for higher-risk groups. As an alternative to antiplatelet drugs, an inappropriate intervention in public health, we propose that the dietary antiplatelet agent Fruitflow®, derived from tomatoes, may be considered a suitable therapy. Fruitflow® contains antiplatelet and anti-inflammatory compounds that target the mechanisms of platelet activation specific to COVID-19 and can be considered a safe and natural antiplatelet regime.

https://www.sciencedirect.com/science/article/abs/pii/S0306987720333715?fbclid=IwAR3j_hzwVFy_bIjH_6hMwQkmQ9lo_Q2p3hpBwdFlNq6r1QWio9b52M3FvEA

DP64, The company, as far as I am aware, has never issued an RNS for any Patents and probably never will. It does however give updates on the status of Patents and this was included in the final results.
"The use of Fruitflow with nitrates in mitigating exercise-induced inflammation and for promoting recovery from intense exercise. The patent was first granted by the UK IPO (Intellectual Property Office) in May 2017, and further patents have been granted in Australia, China, New Zealand and Japan. Applications have been accepted for grant in Europe, the US and the Philippines, and further patents for this formulation are being sought in eight other territories, with potential patent protection out to December 2033."

As you can see, it would get a bit messy issuing an RNS every time one of our Patents was granted in another country.

Asim is still a consultant for Provexis.
https://www.provexis.org/about-provexis/scientific-advisory-board/

As for acceleration of blue hat. I don't think you can.

Clinical trials must be conducted in China for blue hat and this isn't a clinical trial.

Now published
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review

https://www.mdpi.com/2072-6643/13/1/144/htm?fbclid=IwAR3B3_PafwhVn7bpCMBBjxzc2zcmBjmzs7fqut_-Gm5xsDW-AvsSYk_DCDw

New function research
http://www.binh.cn/#/index3?id=2b1d9f2bbde14a8b9f34b425cb40515f
Lots of info on FF including Video in Chinese.

Felix on By-Health, DSM, Provexis and Fruitflow @10min 30 (Chinese)
http://www.binh.cn/#/BINHbbsDetails?id=425bc64a48c24c65ab0480e6fc1310f5&menuItemId=b37766f3e05611ea8e990242ac116a0b

Perhaps davidxie77 could help with any info we don't know?

Thanks.

Just a reminder of some of the Registered Clinical Trials, Publications and Patents found relating to By-Health and Fruitflow in China (except for the last Patent)

Registered Clinical Trials.

Water-soluble tomato extract improves platelet function in subjects with metabolic syndrome: a randomized clinical trail
Date of Registration:2020-12-02
http://www.chictr.org.cn/showprojen.aspx?proj=64530

Effect of combination of Fruitflow and aspirin on platelet function and endothelial cells
Date of Registration:2020-07-13
http://www.chictr.org.cn/showprojen.aspx?proj=56370

Human intervention study on dietary intake of water-soluble tomato extract
Date of Registration:2017-10-10
http://www.chictr.org.cn/showprojen.aspx?proj=22104

Effect of water-soluble tomato extract on hypercholesterolemia
Date of Registration:2018-04-27
http://www.chictr.org.cn/showprojen.aspx?proj=27052

Investigation of the Anti-hypertensive Role of Specific Plant Extracts in Hypertenison Patients
Date of Registration:2018-05-04
http://www.chictr.org.cn/showprojen.aspx?proj=27048

Publications

The water-soluble tomato concentrate Fruitflow inhibits its activation, aggregation and thrombosis by regulating the platelet PI3K/Akt and MAPKs signaling pathways
http://www.cnki.com.cn/Article/CJFDTotal-ZSYK202002011.htm

Inhibitory effect of Fruitflow on platelet function: a randomized placebo-controlled trial in elderly subjects
https://www.researchsquare.com/article/rs-95541/v1

Fruitflow attenuates human platelet granule secretion through down-regulating Src/PLC?2/PKC signaling pathway
https://www.researchsquare.com/article/rs-17401/v1

Toxicological Evaluation of Edible Safety of Water-soluble Tomato Concentrate (Fruitflow?)
http://www.fx361.com/page/2019/1205/6076972.shtml

Effects of water-soluble tomato concentrate on platelet aggregation
https://www.wjtcm.net/article.asp?issn=2311-8571;year=2019;volume=5;issue=4;spage=260;epage=268;aulast=Zhan

Study on the Antioxidant and Auxiliary Effects of Water-soluble Tomato Concentrate in Lowering Blood Lipid
https://r.cnki.net/kcms/detail/detail.aspx?filename=SPAJ202013071&dbcode=CRJT_CJFD&dbname=CJFDAUTO&v

Study on the anti-platelet aggregation effect of water-soluble tomato concentrate
http://cdmd.cnki.com.cn/Article/CDMD-84502-1019240650.htm

Patents

WO2020077747 - COMPOSITION FACILITATING LOWERING OF BLOOD PRESSURE AND DIETARY SUPPLEMENT
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020077747&_cid=P11-KJGTMR-22408-1

CN109380728 - COMPOSITION AND HEALTH-CARE FOOD WITH AUXILIARY BLOOD PRESSURE LOWERING EFFECT
https://patentscope.wipo.int/search/en/detail.jsf?docId=CN238963528&_cid=P11-KJGTMR-22408-1

Not By-Health
CN108524664 - COMPOSITION WITH INTESTINAL AND CARDIOVASCULAR REGULATING FUNCTION AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF
https://patentscope.wipo.int/search/en/detail.jsf?docId=CN228767168&_cid=P11-KJGTMR-22408-1

Not sure why they haven't posted on any of their own study results. Yet.

Xiaotang Nutrition Research Institute
Official account of BY-HEALTH Institute of Nutrition and Health
https://www.zhihu.com/org/xiao-tang-ying-yang-yan-jiu-yuan-77

Couple of posts on the 31st
https://zhuanlan.zhihu.com/p/340843021
https://zhuanlan.zhihu.com/p/340833513
and one on the 23-10-2020
https://zhuanlan.zhihu.com/p/267263667

Hope you are right regarding the results but my money is on the 29th.

Happy New Year to everyone when it comes.

Wishing you all the best in 2021 and lets hope it will be a good year for us all.

Just to state the obvious.... but for Stuart Lucas to say at 9% or above and avoid having to give a TR-1 saying he is now below 9% he would have to have bought around 12 million or more since his last holding notification.

Maybe not then :)

Maybe get a notification today?

Not expecting to see one from Mr Lucas as he would have had to buy something like 34 Million since his last notification to get to 10%
Saying that, If he didn't take part in this fund raise then he would need to notify as going below 9%

Good find Kal-El but I would say its a total coincidence.
If the company had been called Fruitflow UK Ltd then maybe but as it is Fruit Flow.
https://find-and-update.company-information.service.gov.uk/company/13098562

Not sure the Nature of business (SIC) 96090 connects to selling FF to China either.
https://www.siccode.co.uk/sic2007/code-96090

But who knows.

They get a terrible wright up on trust pilot
https://uk.trustpilot.com/review/www.ubuy.com
And will ship anywhere so cant see this being the distributor.
Bit of a con of a site by the looks of it.

24 Dec 2021 is the one I am interested in :-)

Merry Christmas all.

Thanks David.

Hi davidxie, Can you tell if he is a director of any other companies with possible connections to CBEC?

"Hong Kong Fulfillment
Hong Kong is one of the main fulfillment hubs in Asia and a perfect choice if you sell to clients in mainland China and other Asian countries.

In short, you send the products in bulk shipments to Hong Kong where a 3PL company helps you with the inbound, storage, pick & pack, and shipping to end-customers in mainland China.

There are many benefits why Hong Kong is a perfect location for the fulfillment of products. First of all, it has the freest economy in the world with no import duties or VAT.

If you open a Hong Kong company, you can also receive payments in RMB and manage local operations through the entity.

Below I’ve made a summary of both the pros and cons when using a Hong Kong-based fulfillment center compared to a bonded warehouse in China:

Pros:

No tariffs when shipping products for storage in Hong Kong
Easy and fast to register a Hong Kong company
A good way to test the Mainland China market for your products
Cons:

Generally more expensive pick & pack fees and storage costs
Slower delivery times
Goods can be held up in customs (and are subject to changes)
Chinese consumers are subject to an annual quota of duty-free cross-border retail imports"

That was my first thoughts as well BB.

and it would be a good place to base your CBEC to China.
http://www.fungyucpa.com/cbec-in-hong-kong/
https://www.export2asia.com/blog/china-cross-border-ecommerce/

One to keep an eye on.