Member Info for gixer

Water-Soluble Tomato Concentrate, a Potential Antioxidant
Supplement, Can Attenuate Platelet Apoptosis and Oxidative
Stress in Healthy Middle-Aged and Elderly Adults: A
Randomized, Double-Blinded, Crossover Clinical Trial

https://www.mdpi.com/2072-6643/14/16/3374/pdf?version=1660736023

5. Conclusions
The results showed that four weeks of WSTC supplementation could attenuate oxidative stress and platelet apoptosis in healthy middle-aged and elderly adults. In addition,
our study further added evidence that WSTC could safely and effectively reduce platelet
aggregation and activation in healthy middle-aged and elderly adults. Therefore, our
current results indicate that the beneficial effects of WSTC may have a potential role in the
early prevention of ASCVD.

Nah! He only likes to tell you the sp is going down. Even when its not.

Cytokine inflammatory storm ?? Cytokine release syndrome, is a type of immune system inflammatory response syndrome that can occur due to illnesses like Covid. The very severe cases of this condition, called cytokine hurricanes. In simpler words, cytokine hurricane syndrome is a group of related diseases during which the immune system produces many inflammatory signals, sometimes even leading to failure and death. Cytokine hurricane Ken is due to field problems And different diseases happen. For example, in patients with severe coronavirus, cytokine storm syndrome occurs due to inflammation of the internal organs and the immune system response of the body. Most people with Corona do not experience Cytokine storm and only in very severe cases they suffer such an attack. When a person has a genetic history of specific disease or background infections, a virus, like Covid, is more likely to develop cytokine. Cytokine storms are a defective cycle that creates a dangerous condition in the immune system that causes inflammation, organ damage and death. Studies have shown that using Fruit Flu (the effective substance Vestolux) in the early stages of Covid, i.e. before Cytokine storms, can reduce the risk of inflammation, clots and cardiovascular diseases that cause Covid ?? ??

https://www.instagram.com/p/Cgq7g73lPLe/

Vestolux on Instagram letting the cat out of the bag wrt the upcoming patent perhaps??????

Microorganisms ? Our digestive system normally has microorganisms that help maintain the body’s health, boost the immune system and regulate metabolism as well as better absorption and digestion of nutrients from the gut. Microflour is made up of bacteria, fungi, and fermentation, all of which are present in our digestive system. Recent studies have shown that there is an inverse link between digestive microflora diversity and vascular system health. If microflora balance is disrupted or depopulated, it affects the vascular wall and makes the person vulnerable to cardiovascular disease, including sclerosis. One of the effects of Fruit Flow is regulating the population of microbiome of the digestive system, which can prevent the hardness of the vessel wall. ???? Check out our new website
https://www.instagram.com/reel/ChCMrwMFtGW/?igshid=MDJmNzVkMjY%3D

Another tick in the box :)

"Menopause-supporting products the ‘next big opportunity’ according to Lumina report"

"The roles of the microbiome and probiotics in supporting the menopause could be a key growth area as the process, combined with healthy ageing and gut health, gives rise to niche products aimed at women navigating this stage of life.
That’s the view of a new report?? by Lumina that lays bare the emergence of naturally derived treatment options and the market forces combining to create demand."

"Phenology & Frutiflow?
DSM-backed personalised nutrition initiative Hologram Sciences has launched Phenology, its menopause solution that includes a gummy-based daily nutritional supplement regimen for tackling hot flashes and stress.

DSM already make available Fruitflow, an ingredient made from bioactive compounds found in the jelly around tomato seeds.

The ingredient is said to smooth blood platelets, protecting against hyperactivity and unwanted blood clots, which can occur more readily during menopause."

https://www.nutraingredients.com/Article/2022/08/04/Menopause-supporting-products-the-next-big-opportunity-according-to-Lumina-report

I think we have done this to death now but.....

"Now there's an added question...if the Distributor sales did not go through the J&J O/N system and shipped direct then the price per unit/order would be even worse again.

Anyone else got any bright ideas on all this???"

My figures were from the last full year results when only the "first test order has been placed by the distributor and shipped to China" and not made clear if revenue from this test order was before March (year end) and included in these results.

I am sure it was.

Great marketing opportunity as well as I am sure there is a massive rat population in China looking to alleviate hyper-reactivity of the platelets after strenuous exercise.

Its all good :)

BYHEALTH Institute of Nutrition & Health and Institute of Chinese Materia Medica.
"Provisionally accepted: The final, formatted version of the article will be published soon."
"Accepted: 03 Aug 2022."

"Water-Soluble Tomato Concentrate Modulates shear-induced platelet aggregation and blood flow in vitro and vivo"

"Water-soluble tomato concentrate (WSTC), extracted from mature tomatoes, is the first health product in Europe that has been approved "to help maintain normal platelet activity to maintain healthy blood flow". We hypothesized that WSTC might exert influence on blood flow shear stress-induced platelet aggregation (SIPA) and in turn maintain healthy blood flow. We used a microfluidic system to measure the effects of WSTC on SIPA in vitro, We also used the strenuous exercise rat model and the ?-carrageenan induced rat tail thrombosis model to demonstrate the effects of WSTC on blood flow. WSTC significantly inhibited platelet aggregation at pathological high shear rate of 4000 s-1 and 8000 s-1 in vitro (P < 0.05 or P < 0.01). WSTC reduced the platelet adhesion rate and increased the rolling speed of platelets by inhibiting binding to Von Willebrand Factor (P < 0.05 or P < 0.01). The oral administration of WSTC for 4 weeks in strenuous exercise rats alleviated hyper-reactivity of the platelets and led to a significant reduction in the plasma levels of catecholamine and IL-6. WSTC treatment also led to a reduction in tail length, reduced blood flow pulse index (PI) and vascular resistance index (RI) and ameliorated local microcirculation perfusion in a rat model of thrombosis. WSTC exerted obvious inhibitory effects on the platelet aggregation induced by shear flow and alleviated the blood flow and microcirculation abnormities induced by inflammatory reaction."

https://www.frontiersin.org/articles/10.3389/fnut.2022.961301/abstract

Another tick in the box for Fruitflow :-)

Bella, Yes blanket orders could be a reason.

The last run of Fruitflow+ Omega-3 capsules that we know about was completed in July 2021 and the BBE date atm is Jul 23. I am not fully up to speed on the amount of times Amazon has been out of stock in the last year (wellsite might know) but I am sure its more than once???
Would that then mean that if PXS put in an order for FF+O to DSM then they draw down on that order when needed or has China taken more than planned as customer order numbers have been steady for a long time now and it would be easy to estimate run size so the likes of Amazon didn't go out of stock?

Cheers BB,
Not something I believe I was aware of ( "Market Maker holding shares from a placing then, so long as they're below 10%, they don't need to declare.") but then its highly unlikely to be relevant to my portfolio lol.
The original post from Bella suggested that one person or institute? bought the 6% and has been selling them into the market. Like you, I don't believe a market maker would make such a sizable risk if any at all.

wellsite, like Bella, I also believed J&J fulfilled the Amazon orders but if that is the case then why do they always go out of stock on Amazon and not the company website. Strange.

Bella, if a friendly had bought the 133,333,349 shares then they would have to disclose that they were above 3% and in fact they would have been above 6%. Then they would need to notify on the way down.
So, as this didn't happen we can only assume that the shares were bought by at least 3 people and the RNS does state that it was "new and existing investors"
As alfisa says, there has been no evidence that these shares have been sold in full although some may have been in the last 18 months or so.

Quick sums.
Fruitflow+ Omega-3 achieved sales of £138k in the year to 31 March 2021, (last full year)

Order #134336 (12th April 2020)
Order #164119 (8th March 2021)
= 29,783

£138,000 ÷ 29,783 = £4.63 per packet.

PDYOR etc etc.

That would suggest why there is no spike in order numbers when stock gets sent to China as its not in the J&J system.

No way of estimating this (until Y.E.?)

https://baijiahao-baidu-com.translate.goog/s?id=1738680347571441051&wfr=spider&for=pc&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp

Strange behaviour indeed.

Regulatory approval in China is the one we are all waiting on but By-Health isn't just about China.

This was a reply from By-Health Australia on Facebook a while back.
http://postimg.cc/VJ481Hd7

The monthly order numbers seem to be pretty constant over the last year or so although subscriber numbers are at an all-time high level as reported in the interim results.
What we cant see in the graph is the Holland & Barrett and the Chinese Distributor order quantities.

If, for example, the Chinese distributor ordered 400 packs. Would this increase the order numbers by 1 or would it be a different system for H&B and China?

Your fears don't appear to have put By-Health off at all so I think I will hold for now :)

https://fit4you.sk/en/obchod/fit4you-slim-coffee/

https://fit4you.sk/en/obchod/fit4you-senior-plus/

Translated links didn't seem to show the products?