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https://www.abstractsonline.com/pp8/#!/10828/presentation/2606

We have demonstrated that the pre|CISION™ substrate is exquisitely sensitive to FAP and is not cleaved by related proteases. The active AVA3996 warhead should therefore be released primarily following FAP cleavage in the tumor microenvironment.
Cancer cell lines were assessed for their sensitivity to AVA3996 in vitro: activity was typically 100-fold less than the active warhead or Bortezomib alone. Upon co-incubation with soluble FAP, potency of AVA3996 increased to similar levels as seen for the warhead alone demonstrating the masking effect of the pre|CISION™ substrate. A DRF/MTD study established the maximum tolerated dose in rats was around 6-fold higher for AVA3996 compared to warhead alone. This provides further evidence that AVA3996 can be dosed at higher levels than proteasome inhibitor alone, with the potential for greater tumor targeting and hence reduced systemic toxicity.
Ongoing in vivo and co-culture studies aim to further validate the efficacy and tolerability profile of AVA3996 to direct future development of this drug. In addition, the data supports wider utility of the pre|CISION™ platform to target therapeutics to the tumor while reducing systemic dose-limiting toxicities.

I 100% believe GMCC he is genuine !
We should be discussing why Cohort 5 has not started ?
1) Waiting on dosing levels ( doubt this as it shouldn't take 8 plus weeks )
2) In talks with a Major Player and they have asked for a pause ( Knowing how good current results are ? )
3) FDA Fast track imminent .... doubt this would have stopped us continuing ?
Please feel free to Add / Discus

GMCC 100 % genuine

everyone looking for shelter .... just need 1 good RNs and money will poor in IMHO

Perhaps we will get a taster in readiness for the Big reveal in May ?

https://meetingonthemed.com/company-presentations/?n=affyxell-therapeutics

Thanks GMCC

17 th Jan was the last meaningful RN's 8 weeks ago .... Can't wait next News !! let's hope it's something huge ... Personally I think they have been dosing at higher level's let's wait and see ..... GMCC thanks for all your research !!

Thanks for sharing GMCC

Say's the muppet who ask for advice on the Metro thread LOL

accusay exhibiting ...... might have something new ? you never know :)
https://www.biomedica.ie/exhibitor/accusay-diagnostics/

Site down today ? Being Updated perhaps

really asking that question , your supposed to be an expert LOL muppet ...... Going down crap results best get back into some dodgy oilers

Don't recall 11 investors in Affyxell ... could be wrong ?
http://affyxell.com/media/partner.php

One to note slide 27 AffyXell and Avacta present Data regarding Cell & Gene Therapy in May .... Plenty News On the Horizon
https://www.isctglobal.org/isct2023/program/2023plenaryandconcurrents

This is getting stronger day by day .... weak sellers slipping away whilst we build strength !

https://twitter.com/RAH00084/status/1628655140214276099

Excellent !

Terry you really are a B End ..... Schools open at 9 best get ready .... Oh check in at lunchtime if teacher allows ..... We will be up ......

institutional investors and analysts .... Big Re Rate coming

institutional investors and analysts ..... Big Re Rate coming