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They were in CINE, along with Polyg. Small world eh.
Thanks for the heads up, good to know of increased interest, all bodes well.

And if any of those are deemed risky to use against Omni (i.e. if they prove to accelerate problems instead of fix them), then you can see how supply is going to get even more squeezed. The flip side of this is big pharma will, IMO, pull out the stops to keep manufacturing as much as possible, or find alternative ways to meet that demand if the need becomes so overwhelming. But we don't know yet how Omni will impact so just musing at this point...

The problem is already supply, not demand.

Merck are estimating to have 10M courses available by the end of 2021.
Pfizer will only have 180,000, although they say this will jump to 50M by the end of 2022
During the initial vaccine rollout, both Pfizer and Moderna delivered less vaccines than promised to some nations.
The current supply of oral antivirals isn’t high enough to prevent disaster from a new variant. It isn’t even enough courses for the variants we have today. Currently in the US there are +45k patients hospitalized with Covid-19. During the peak of the Delta infection in India, there were more than 800,000 cases reported per day.

Get the wine order in early Tony, last year was a good lesson!
Chin chin, here's to Synair-gin!

Thanks for posting CityTT, most useful.
Under 3rd bullet "We are most specifically concerned over treatments that have the potential to place selective pressure on more conserved regions of coronaviruses. Accelerating the evolution of endemic coronaviruses may have significant unintended consequences"
This has go to be a real concern now.

Doc83, what the epidemiologists are saying tonight:

“ For individuals who have been double-jabbed and infected with Delta, the picture is better still. “If you’ve been double-jabbed and then infected with Delta and recovered, then you have got a very broad, very effective immune response, that probably covers pretty much any variant that you can think of,” said David Matthews, professor of virology at the University of Bristol. This is because such individuals have been exposed to the virus (through infection with Delta) and the spike protein from the original Wuhan strain (through vaccination). “It means you’ve got an antibody response that covers both classic and modern strains and a very broad T cell response, not just against the spike protein, but against all the other proteins that Sars-CoV-2 makes – and that’s incredibly helpful,” Matthews said.
The biggest worry is for those who remain unvaccinated. “If they are right that this virus is even better at transmitting than Delta, and it looks like they are, what will happen is that it will speed up the rate at which this virus finds the unvaccinated and puts them in hospitals, and that will therefore increase the pressure on the NHS,” said Matthews. “That is what will trigger a lockdown, if hospitalisation rates go above a certain threshold, whatever that is.” The Guardian.

According to the data from SA epidemiologists, the vast majority of Gauteng hospitalised are unvaccinated, or only partially vaccinated. Dr Eric Feng didn’t mention this because he’s not an epidemiologist, he’s a nutritional expert. So, I think you’ll find the data say’s that yes, it actually it does work.

Doc83, unfortunatley, as you can see from the data yourself without the governments's telling you so, Covid-19 is a novel disease, there is no prior experience and there many unknowns. To be fair to governments (and as you will know from my posting history that I judge them pretty firmly!) they are navigating a public health catastrophe not seen in our lifetime. They have to balance the public health of many against the beliefs of a few. I'm guessing you were jabbed for polio as a baby, as was I, as were many. It was done to protect many millions from ever suffering the misery of contracting that vile disease. They weren't doing it to curb rights and beliefs then (unless they did it and I missed it in the intervening decades!) and they are not doing it now. Think about that.

Yes it is worth a read. I think it's fair to remain or governments to remain cautious until more is known, and that will take time. SA has a relatively young population compared to a lot of countries. Looking back at how the pandemic took hold in the earliest days in Europe in Italy, it was first the older adults and those with underlying chronic conditions that got hit hardest, avg. age in the 80's, but then that changed in subsequent waves. THe same could be true of this variant, it has affected mainly younger healthier SA's, but who knows what it will do to an ageing population. As RM has said a few times, we just don't know what his virus is capable of.

2 large late trades Friday, markets spooked by Omni. Thought for 8am Monday open?

"Overall, we rate Primary Doctor Medical Journal (PDMJ) right biased and a quackery level pseudoscience website based on the publication of misleading and false information related to the Coronavirus."
https://mediabiasfactcheck.com/primary-doctor-medical-journal/

Quackery.

Yep. Filed under ‘Candace Owens Twitter disciple’i in the Tramp/Maga stupidty bin.

Dr Coetzee "a GP for 33 years who chairs the South African Medical Association alongside running her practice". I don't think her observations are irrelevant, but you are right in so far as more data is needed. Anecdotal evidence from a professional on the ground (as opposed to some anonymous poster on Reddit) is still evidence, and it's the best the world has to go on right now. Be thankful that the SA scientists and medical fraternity are sharing the limited information they have - stark contrast to silence of the Chinese authorities of 2 years ago.

Agree Tommy, that is a worry.
Ref the high pulse rate observed in SA patients, I think the guidelines with optometers which a lot of people now have (the finger ones that check pulse and oxygen level) is a pulse rate over 100 the advice is to contact 111/GP etc, basically get it checked. Imagine if enough people get the new variant, GPs/111 won't cope with that amount of referrals, even though the illness itself might seem mild enough. I'm thinking aloud here, which is all we can do until more evidence, but you can see how such a new symptom could cause havoc.
Also we don't know to what extent current tests pick up the new variant effectively or whether specialist labs have to process. Another unknown maybe.

The bottom line is demand for Covid therapeutics globally is outstripping supply. Governments are right to buy whatever is available now even if efficacy is not great - it's a numbers game on saving lives. It's not like they have a lot of choice, millions are dying of this disease, there are riots on the streets and the word economy is crippled.
When something better comes along, demand will switch to that, same as it has always done. Enter SNG001.

Thanks for posting this (bloom.labs) Xviolet, interesting.

Morning. Same news is also here:
https://www.dailymail.co.uk/news/article-10248551/Dozens-passengers-arrived-Holland-South-Africa-test-positive-Covid.html

Matterhorn,
There is no definitive evidence yet that it is more transmissible but the signs indicate it may be; signs being the surge in numbers in Gauteng province and the higher R number there which is 2, but 1.5 nationally.

yes based on information from US, you are correct (I meant the DR/vid is Indian).

Matterhorn
It’s not the US, it’s India.

If it’s 2 buys why the low/barely unchanged SP, relative to what it was beforehand?