RE: Buyers returning1 Jul 2024 23:04
Proposal is accepted, the consortium will:
Establish the CIRRP platform within an existing OBD ISO15189/UKAS accredited clinical laboratory to offer UK-based EpiSwitch CiRT and HiRT clinical screening on at least 350 patients - in prostate, colorectal, breast, ovarian and lung cancers, initially at the NHS trusts within the consortium, and then across NHS networks across the UK, using an established transparent cost per patient sample model.
Create real-world impact data within NHS clinical practice for prediction of ICI response and prognosis of Hyperprogressive disease (HPD). The initial focus will be NHS patients considered for or currently receiving anti-PD-1 or anti-PD-L1 ICI treatment for prostate, colorectal, breast, ovarian and lung cancers. Understanding the distinct Objective Response Rate to ICIs means precise understanding of rates of response/non-response to treatment, immune-related adverse events (irAEs) or HPD becomes critical.
Advance the understanding of genetic, metabolomic and epigenetic mechanisms behind clinical outcomes, acquired resistance and remission. The world-class expertise of the research team will be guided through the multiomic complexity of genomes by focusing on the functional genomic footprints of networks of 3D EpiSwitch biomarkers strongly associated with clinical outcomes of ICI treatment.
Funny, because that speaks volumes also