RE: Oxford Corvid Challenge Trial31 Aug 2021 14:22
Maybe to reenforce Herne's point:
One of the benefits of running at near 100% capacity right now is that there's always _some_ kind of demand for ORPH's services.
If Covid (let's hope) eases off, and demand for Covid challenge studies falls away, we have an endless list of viral and bacterial vaccines: HRV, influenza, RSV, malaria, other coronaviruses, asthma/copd, parainfluenza, ...,
I think there are two important facts:
(A) governments and companies finally prioritising vaccines, so plenty of products coming down the pipeline
(B) human challenge studies are finally being recognised as the preferred way to evaluate the early efficacy of the vaccine in vivo, and give strong objective analysis of the prospects of the vaccine; this includes early termination opportunities, which save lots of money and reduce risk to larger populations. It's better to eliminate duff vaccines early and deploy only ones likely to succeed to P3.
I think human challenge could become the gold standard for vaccines where it's safe to do so (i.e. rescue available).