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583 / 17 - AVA3996, a novel pre|CISION™ medicine, targeted to the tumor microenvironment via fibroblast activation protein (FAP) mediated cleavage
David H. Jones, Marine Houée, Hanna Buist, Sergi Marco, Chiara Braconi, Neil Bell, Francis X. Wilson, Fiona McLaughlin. Avacta Life Sciences, London, United Kingdom, University of Glasgow, Wolfson Wohl Cancer Research Centre, Glasgow, Scotland, United Kingdom

Google aacr 23

Search Avacta
It’s there in green and white!!!

Presentation april 16th 130pm

They are presenting

Make no mistake Avacta are sitting at the big boys table at aacr 2023
Avacta are all over this
Sitting with Roche Merck sanofi Astra Zeneca takeda

This will be massive

From aacr

AVA3996 has the potential to deliver elevated, effective levels of proteasome inhibitor directly to the solid tumor microenvironment while reducing systemic exposure and hence associated toxicities.
We have demonstrated that the pre|CISION™ substrate is exquisitely sensitive to FAP and is not cleaved by related proteases. The active AVA3996 warhead should therefore be released primarily following FAP cleavage in the tumor microenvironment.
Cancer cell lines were assessed for their sensitivity to AVA3996 in vitro: activity was typically 100-fold less than the active warhead or Bortezomib alone. Upon co-incubation with soluble FAP, potency of AVA3996 increased to similar levels as seen for the warhead alone demonstrating the masking effect of the pre|CISION™ substrate. A DRF/MTD study established the maximum tolerated dose in rats was around 6-fold higher for AVA3996 compared to warhead alone. This provides further evidence that AVA3996 can be dosed at higher levels than proteasome inhibitor alone, with the potential for greater tumor targeting and hence reduced systemic toxicity.
Ongoing in vivo and co-culture studies aim to further validate the efficacy and tolerability profile of AVA3996 to direct future development of this drug. In addition, the data supports wider utility of the pre|CISION™ platform to target therapeutics to the tumor while reducing systemic dose-limiting toxicities.

Thought it wasn’t but it is !!!
Yehaa

Don’t read it
Dear god
Just don’t read it

Eg : I can’t get abused on Facebook because I don’t have Facebook
Hope this helps

Exactly bamps
The share price is irrelevant now unless you need the money to get out
Look on the bright side its 7p and that is utterly ridiculous or utterly amazing
I’m just buying at these prices whenever I can until they go bankrupt!!!
Long term holder here!!

I’m also not sure if people know how shorting/spread betting works
It’s a big part of lse bulletin boards and others
Some are very clever and some are extremely dumb
Either way if you’ve done your research on a company they mean zilch

They are on Avacta daily spouting rubbish
They are everywhere
Filter or delete lse account and I promise you won’t get frustrated

What a wonderful opportunity to open up accounts for your kids and yourselves
Just 7p a share
This will grow and grow and grow over the next few years
Absolutely fantastic opportunity
Solid as a rock

Turquoise finish all day long

Finishes blue all day long

I filtered them ages ago
So should else

You simply cannot argue that Avacta aren’t going places.
The evidence/research is pointing to a monumental step forward by this company.
It’s all for everyone to be seen aswell
It might not be in a few weeks/months but big deals or a large buyout must be on the cards
It’s just getting ridiculous
Baffling that the share is what it is but certainly not worrying.
I liken it to telling ronnie O’Sullivan to make a 50 break with 25 reds in the triangle and all the colours on there spots!!!
It’s just ridiculous

I used to think hurst was serious when I first joined here!!

This will be multiples of 7..4p in the near future and double multiples in the long term
Absolutely bonkers buy and no brainer from here

I do not worry about this one!!!

All the best

I’m going 1 hour 12 minutes

About £150 k in this now from me
Been given the nod by my pharmaceutical cousin
All the best of luck to all ?