RE: Preclinical Development of PNT6555, a Boronic Acid–Based, Fibroblast Activation Protein-α (FAP)–AP-Positive Tumors17 Feb 2024 15:46
Looking at the use of joining canSEEK = preCISION with Actinium 225:
“Alpha emitters such as actinium-225 are favored in cancer treatment because of the short range (a few cell diameters) of alpha particles in tissue and their high energy, rendering them highly effective in targeting and killing cancer cells—specifically, alpha particles are more effective at breaking DNA strands. The 10-day half-life of 225Ac is long enough to facilitate treatment, but short enough that little remains in the body months after treatment.[10] This contrasts with the similarly investigated 213Bi, whose 46-minute half-life necessitates in situ generation and immediate use. Additionally, 225Ac has a median lethal dose several orders of magnitude greater than 213Bi because of its longer half-life and subsequent alpha emissions from its decay products. Each decay of 225Ac to 209Bi nets four high-energy alpha particles, greatly increasing its potency.[10][13]
Despite its limited availability, several clinical trials have been completed, demonstrating the effectiveness of 225Ac in targeted alpha therapy.[8][13] Complexes including 225Ac—such as antibodies labeled with 225Ac—have been tested to target various types of cancer, including leukemia, prostate carcinoma, and breast carcinoma in humans.[13] For example, one experimental 225Ac-based drug has shown effectiveness against acute myeloid leukemia without harming the patient. Further clinical trials of other drugs are underway.[10]”
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