Member Info for crumbs

The one-two punch that hopefully overwhelms and knocks out cancer (in a majority) and stops it from evolving evasion ...

It is not so much about mechanisms of SCIB1 failure but of mechanisms of melanomas ability to evade or survive ..... There is no one cure-all for late-stage melanoma I think we know this from our own mono trial in which patients had been on and went onto other treatments including PD1 .... the trial is about two approaches with proven data... obviously in PD1 much more proven to the point of being commercial being able to work synergistically together to get better results than either can in mono due to their unique ways of triggering an immune response against the cancer.... brakes off (PD1) accelerator on (SCIB1)....

'if a combination trial failed (especially if it lead to patient deaths) '
It is a trial in late-stage melanoma patients!... There will be patient deaths the idea is less than would be normally expected....

Not sure Warren Buffet struts around anymore anyways it is nice to see that strangely all of a sudden we are all no matter what supposed group we belong to seem to be on the same page at least with enjoying the current direction of sp and hopes of much more good news as maybe for once we are all now' in it' together :) .... and a bit of bants among the one happy family is fine I think until the great Xmas bust-up lol..... onwards to whatever tomorrow brings.

In the club though... the C7 a popular larger with a frothy head is the..... best seller lol

A pint of nana is a full-bodied undiluted stout.... at 8 quid a pint though..... phew

though possibly spelt bazooka..... depends on how many you've had

With a brand of beer 'The Bazzoka' a pale ale - and longlasting bitter

Yes, indeed time will tell it is a pity the question did not get asked in the proactive presentation ...What we got was an outline of what pre-clinical mab assets are currently going for in deals that ours may well not be that kind of deal (I may have taken that as the Avidimab factor being involved) and that AvidiMab itself has a slightly different business model than the MaBs.... Still loads of info to be learnt here not least on what and whos nano delivery has been chosen for SCIB2 and who has licensed it... if scancell would it not have been RNS'd ... which leaves CRUK have licensed it and progress is coming there....

'The Avidimab addition to these anti-glycan mabs (and any mAb if engineered with Avidimab in) allows the direct killing of a cell labelled with the antibody WITHOUT the need for either of the two mechanisms above. As the effector functions are retained even with Avidimab added, you may get all three mechanisms working in parallel.'

Which even though the deal being negotiated seems to be only for one Glycan asset I think with respect to boom that it will also include a deal on Avidimab if that is for sole use with the one MaB or others or indeed is even the case remains to be seen.... but you would think after all the research the collab partners are either liking AvidiMab or are not convinced....

'Exactly the same sugar you have in your tea' .... so said Lindy :) (probably not measured in spoonfuls though)

next AGM will probably be a virtual one

Just to see scancell back above 10p is a wonderful sight :) .... for sure traders will be here a lot now getting their 10%'s why not... no 3p raising of doom to keep the lights barely flickering is coming here .... a deal RNS very possible and not just for MaBs...Covidity on the map and scancell part of the UK Gov backed drive for CV19 vaccine one that is looking more scientifically appealing by the day...could that also find itself a pharma partner? hmmm.... so all good and if there are any more 0p shares going I'll defo take a few!

Why the rise T cells are vital and that this company as one the foremost T cell experts in the world who has developed in house 3 platforms.... the scientific world is catching on... this is just the market catching up.... wait till those real deal valuations arrive :)

Feels like for the first time in 1 zillion years I am about to be back in scancell profit yay lol.... Just need ONW on and on to turn up now to tell us the long-frustrated will sell off in droves as soon as they see a profit.... nah not a chance come on that first MaB deal I can almost smell it uhmm sweet....

'top heavy in the management chain (too many chiefs not enough indians) and that is financially expensive'

spot on! .... managers getting paid manager wages to do postie work - far too many managers who end up causing problems as they feel they have to be doing something to justify being a manager that something is usually something that causes chaos in offices and causes workplace relations issues etc etc .... most managing work could be done by part time none manager office worker staff

I'm not sure 'we' as in all posters here all want scancell to succeed. as I doubt some posting here hold any shares at least currently (historically burnt perhaps ).. I do think anyone rational wants cancer to be cured and the attraction here is the science could hold a few of the keys to unlocking that end ...

Rats it seems there is a palpable fear(among a few) of a first commercial deal mist probably on a Glycan asset possibly including Avidimab.... I cannot think why.... what because that is the plan and it is happening? as is modi1 trial now fully funded... seems some prefer endless timelines and nothing to come... A strange breed

What value would you put on modi1 one product of one pipeline if in the initial 4 cancer targets in the upcoming trial by the end of next year all the data is saying immune responses and tumours dissolving in days in a majority of patients?.... only that product of that platform is not a fantasy and those results well they are what are being seen pre-clinical and ImmunoBody exceeded pre clinical expectations.... so I think you need to re visit the word 'fantasy' and replace it with 'possible' though yes one step at a time the steps are becoming more rapid and the time is coming now.... tick............tock..... then there is indeed ImmunoBody in combo with CI and nano delivery and now a peoptide delivery funded by Gov Uk :) then 5 glycans one of which has very interesting 'alll solid tumour' potential then Avidimab then covidity and potential of going beyond Cancer... modi2 modi3 SCIB3...4...... and who knows what else Lindy is coming up with.... fantasy nah

Timelines wise and I know this is a very sore area here lol but within (surely well within) 8 years scancell ought to have a lot of trial data and that data being impressive enough (especially in modi1) then scancell would I think have some very impressive partnership deals with some if not all the biggest players in oncology pharma ...meaning Redmile Vulpes and even me might well be well out but well minted lol .... though I dunno living off the potential dividends is a nice idea too :).... At least things are beginning to happen in the right direction how far and where to yet to be seen... I've got my ticket though!