Tumour regression in mice took up to 4 days18 Apr 2023 13:51
4 mice days = 160 human days = 23 weeks.
HLA-DP4 mice with a large tumor burden were subsequently vaccinated with Modi-1 or adjuvant only and tumor infiltrates were analyzed. To account for variation in tumor growth between mice, they were vaccinated when tumor diameters reached 8 to 12 mm and tumor
infiltrates analyzed after 4 days. Despite Modi-1 vaccinated mice showing slightly larger tumors at vaccination point compared with the control group (p=0.0030), comparison of tumor volume pre-immunization and at day 4 post-immunization show regression in the Modi-1-immunized mice (figure 2Ai). Tumors from Modi-
1-immunized mice showed evidence of rapid tumor progression within 4 days of a single immunization which was not seen in control mice receiving adjuvant only (figure 2Aii). Seven out of 10 Modi-1-immunized mice showed evidence of tumor shrinkage, measured as tumor volume change, with the remaining 3/10 showing stable disease whereas mice treated with the
adjuvant alone showed 7/9 mice with tumor progression and 2/9 with stable disease (figure 2Aiii).
1. Victoria A Brentville, Rachael L Metheringham, Ian Daniels, Suha Atabani, Peter Symonds, Katherine W Cook, Mireille Vankemmelbeke, Ruhul Choudhury, Poonam Vaghela, Mohamed Gijon, Ghislaine Meiners, Willem-Jan Krebber, Cornelis J M Melief, Lindy G Durrant. Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses. Journal for ImmunoTherapy of Cancer 2020;8:e000560. doi:10.1136/jitc-2020-000560.
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