Ryan Mee, CEO of Fulcrum Metals, reviews FY23 and progress on the Gold Tailings Hub in Canada. Watch the video here.
Great insights - thank you as always.
With regard to trial recruitment and the clinical trials website (both .gov and Penn) Do all trials have to recruit via these channels, curious as I am wondering whether patients may be recruited by other means and we could receive a surprise by way off "first patient dosed" as HK previously alluded to. Thanks all!
Thanks HK very helpful report !
Now I feel spoilt ! Thank you
Thanks so much - some homework over the weekend. Have a good one !
Question for Haywain - again - sorry!
In my simple mind the car t is developed and in its final form. So when we inject our first patient we should have an insight into how the product works as a whole right? Do the fda allow tweaks along the way if needed? What does a successful phase 1 look like in percentage terms in your experience?
Thanks as always!
Thank you!
Anyone know what CMR is?
Have to say I’m very happy Vlad has moved away from Burton and TMS towards Proactive. A very good update !
Sharing some research from imperial following my earlier question to HK.
ClinicalTrials.gov is a publicly accessible database, which is free to register details of your clinical trials. For ClinicalTrials.gov, you are only required to register your study if it is defined by the first four categories of question two on IRAS as either:
Clinical trial of an investigational medicinal product
Clinical investigation or other study of a medical device
Combined trial of an investigational medicinal product and an Investigational medical device
Other clinical trial to study a novel intervention or randomised clinical trial to compare interventions in clinical practice
If it doesn’t fall under any of the definitions above, you are still able to register it but you aren’t required to.
@HemoKnowledge
May I ask - will the clinical trials website in the US show or trial or do not all go on there?
Thank you!
It’s a shame to see the volumes aligning to Dhubs post around 13:00. This board is exclusively retail and seeing patterns like that is pretty disappointing
Echoing Dhubs comments on the email.
Have to say this has been the hardest trading day since the clinical hold was imposed.
Seeing that Vlad is sharing a bit of our pain and was disappointed with what’s happened is reassuring.
Let’s get in the clinic and get this data!
Just to add Hulver I did think the same however the one we found in Sept following the presentation video is baitbio.com - which is still up. There are now two baitbio.com and baitbiotechnology.com
Spotted Vlad has registered another domain. Still no website - one to add to the watch list. http://baitbiotechnology.com/
Great value add - thanks for letting us know
Some interesting reading - https://www.linkedin.com/posts/prevail-infoworks_new-initiative-launched-to-accelerate-the-activity-7166485034168750080-1C6B?utm_source=share&utm_medium=member_ios
Sure - Haywain
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RE: CBR - Hemo Achieved Proof Of Concept for Braian Cancer!28 Sep 2023 23:52
I have had a 16 hour work day so far and that was quite a lot to process - Did I hear correctly CBR - developed into mRNA construct that will be combined with synthetic polymers to presumably be administered through some sort of aerosol to pneumocyte tissue which in turn would produce the protein chimeric bait receptor activating macrophage to respond to anything that binds the bait - Then secondly that they have demonstrated (ie proof of concept) that if they engineer human haematopoetic stem cells and inject them into mice that you can see the cells in the micro glia ( which I think is the immune system component specific to the brain (because of the blood brain barrier) - Additionally systemic immune cells dont cross the B/B barrier - So some how the haematopoetic stem cells when injected into mice inform the brain's immune system (new to me). They then plan to use this to engineer haematopoetic stem cells from the patient with CBR raised to a marker(s) of Glioblastoma brain tumours as a form of treatment. - I need to sleep on it and I promised my self that I have enough of these shares but I am considering dipping my toes in again.
Have to say another fantastic call from our in house scientific advisor. This is exactly what he picked up following the BaitBio video on Youtube!
Market Makers will take the order then work it through the book for however long. I.e you sell 1m shares in a clip (you’ll get an awful price) then they will drip feed the order out and report once complete