We would love to hear your thoughts about our site and services, please take our survey here.
More on Manaus Variant here for anyone interested
https://virological.org/t/sars-cov-2-reinfection-by-the-new-variant-of-concern-voc-p-1-in-amazonas-brazil/596
ATB
Brazil Manaus is the biggest threat to life after vaccination This appears to be a New Phenotype .. A new Linage which they have called P1
This is the Variant that Scancell is concentrating on, its my considered opinion we might be into the summer before this gets to us and could be a very serious issue next "season" The issue is these "variants" are not "individual" they appear to pop up spontaneous with further variations
so just closing borders may not prevent the appearance. The UK 501y variant proves that, with multiple examples of the 501 appearing in other variants for example South Africa
If Scancell can induce an immune response against the "N" which is the conserved area of the Virus, the Scancell vaccine could be essential as a base forming immunity against all variants, I still consider the Scancell vaccine is probably the most valuable vaccine against Covid because of the difficulty in building multivalent vaccines quickly, indeed its not the same as "tweaking" Because Scancell can "Focus" the Lense on vaccination its far more potent than a single Antigen based vaccine like MRNA and Oxfords viral approach this time around Scancell is 6 months ahead rather than being 6 months behind because it is already a multivalent vaccine
https://www.sciencemag.org/news/2021/01/new-coronavirus-variants-could-cause-more-reinfections-require-updated-vaccines
Hi Krafty,
Good to see you still here, a long flog but getting closer to some possible great news I guess.
Seems a long time ago we flew from Gloucester to East Midlands Airport together for the AGM in the business jet!.
Hope you are well and best wishes to you.
Sas,
This extract from your link I find interesting and shows how essential SN14 could be
"These data also have implications for the effectiveness of SARS-CoV-2 vaccines, which are principally
based on immune responses to the spike protein. Neutralizing antibodies have repeatedly been
demonstrated as the primary correlate of protection for most vaccines, including those designed to
prevent infection with respiratory pathogens34
. Despite neutralization escape, we show here that a
significant proportion of non-neutralizing, RBD binding antibodies remain active against 501Y.V2. While
antibody effector functions elicited by infection and vaccination have been implicated in protecting from
reinfection and disease35,36, the role of non-neutralizing antibodies and the efficacy of T cell responses to
501Y.V2 remain to be elucidated. Ultimately, the correlates of protection against SARS-CoV-2 infection
and severe COVID-19 disease remain undetermined and rely upon ongoing large-scale clinical trials.
Nevertheless, the speed and scope of 501Y.V2 mediated immune escape from pre-existing neutralizing
antibodies highlight the urgent requirement for rapidly adaptable vaccine design platforms, and the need
to identify less mutable viral targets for incorporation into future immunogens "
ATB
Thanks for the link too
https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586
"" The recent emergence of variants with multiple shared mutations in spike raises concern about convergent evolution to a new phenotype, potentially associated with an increase in transmissibility or propensity for re-infection of individuals.""
We are so close now ......... You now cannot dispute the value of Covidity if it does generate an immune response against the conserved area
of the Virus ..........
wow !!
Out of 47,780 people who were discharged from hospital in the first wave, 29.4 per cent were readmitted to hospital within 140 days, and 12.3 per cent of the total died.
Study author Kamlesh Khunti, professor of primary care diabetes and vascular medicine at Leicester University, said: “This is the largest study of people discharged from hospital after being admitted with Covid.
“People seem to be going home, getting long-term effects, coming back in and dying. We see nearly 30 per cent have been readmitted, and that’s a lot of people. The numbers are so large.
“The message here is we really need to prepare for long Covid. It’s a mammoth task to follow up with these patients and the NHS is really pushed at the moment, but some sort of monitoring needs to be arranged.”
The study found that Covid survivors were nearly three and a half times more likely to be readmitted to hospital, and die, in the 140 days timeframe than other hospital outpatients.
Prof Khunti said the team had been surprised to find that many people were going back in with a new diagnosis, and many had developed heart, kidney and liver problems, as well as diabetes.
hTTps://www.telegraph.co.uk/news/2021/01/17/almost-third-recovered-covid-patients-return-hospital-five-months/?li_source=LI&li_medium=liftigniter-rhr
Berm,
Sorry to disagree with you on him being banned on this BB, it was on VAL, so a blanket ban prevents him from posting very good information on this SCLP BB, as do you and others IMO
Yes, I agree he should be allowed to return to the SCLP BB.
ADVFN is toxic, you know that and many here just can't visit it, although I do take a look once a day.
I will continue to post only informative posts from him as long as people allow this and don't have me banned.
Everything I re-post is just information, none confrontational, so what is your problem, just don't get that at all.
I also accept that over there on the dark side there are also some very good sources of information, just seems that it is totally unregulated.
ATB anyway, my best regards to you
Ruck, thank you, much appreciated 47.89% is substantial though, still a large holding for us PI's
Regarding re-posting, I don't think that violates LSE either, if it is informative rather than challenging, many posters do the same including Bermuda and others.
IMO excluding information from Inan is detrimental to our BB here on LSE, I have sight of some very interesting information from him, which I have been instructed by Inan NOT to repost, so there you have it.
Is it at the loss to this BB, probably yes.
ATB
Berm,
I think you miss the point here, Inan was banned through posting on another BB on LSE (VAL I think), so your logic is totally flawed.
I can't belive you would prefer to do without his investigative skills to the detriment of this SCLP BB, unless he has the ability to scratch your itch?
As far as I am concerned, ALL knowledge/ research regarding Scancell should be shared and we can all as adults sift out what we wish.
@Ruck, Could you do your speciality and let me know our PI % holding in Scancell please, it's changed I think withe the "D" word, think we held around 45% last time I looked.
Anyway, happy to read all views without getting upset, happy chappy mostly
ATB
Hi C7,
I think re- posting anything that may be interesting from Inan here is of value to all here, but with the advantage that as it is via a third party there should be no challenge problems which has in the past caused some really big spats.
Just my opinion though, if it is causing problems then just let me know .
IMO we are still quite low on the science front, which is really what this share is all about.
LL, just love my walks, fresh air and try to time my walks for Ken Bruce (R2) and JV again around early afternoon, lifts my spirits until real drinky time which is becoming earlier every month!
Take care everyone, not too long now I hope, can't believe it's going to be 12 months of our lives living like this.
ATB
awonda
"""Thanks very much for sharing the documents!
I think that Scancell's Covidity is the way to go, but I'd caution against taking the failure of PCR tests as the evidence for that statement. (there are many other excellent reasons)
The PCR tests are not based on many bits of the spike and the change of a single base should lead to a PCR failure but should not lead to the failure of a vaccine which will have produced very many antibodies attacking and blocking very many different sites on the spike. I preferred the focus on the very long lasting T-Cell response to the N protein previously highlighted by others as the reason.
I hope I wont be proved wrong when they do cross reactivity testing in the blue boxes of figures 8. (as it would be bad for all of us)"""
--------------------------------------------
the post was related to "re-infection" not a vaccine induced immune response
its not so much as the failure of a vaccine its the resultant efficacy loss
as i have previously tried to explain ... Sterilise rather than just reduce symptoms is the Holy Grail as that would induce herd Immunity
vaccines that still allow infection also allow immune escape of a chance variant
like wise reinfection of a variant keeps the ball rolling ...........
this all highlights why Scancell will remain a highly valued stock if it can induce the Potent T cells as promised
some immune compromised patients have remained infections despite some receiving 3 plasma antibody transfers for over 90 Days
Https://watermark.silverchair.com/ciab014.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArMwggKvBgkqhkiG9w0BBwagggKgMIICnAIBADCCApUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMdPjzTDCJqjFjtDovAgEQgIICZjmi5NUmek8BLVwq8LezvsqNFfDodmOTir7-5cQ-kOuu6h7FvtBQbU8lLbxpePENjnmvQ78araJy-_WfWmb0VKdjXaEzgpZB6DA8Tj8fnBOl-STIEvvwfMgQk3FTWOAL4M2EUiQaLK5NbfDF9K6eTCezYEfFnmNd1y31ycKVHEioFEwDaiH382rJp1gtQ7UibS0zNIcZeCJjYMs-G0jGP8cKWOLiIG-Z4E6Eeu1Lb288P5vVkjS6Iezkl9eZ2YOpRiZTsuf2Hi193kSbdVr_TwrNL35Q7jEyDiHXsHcmNTsC8Jaqxj_Z2jFwHlwo8WrjqzRcolaY0Q2WJDDJkjfkvJXVqnNVMJW5QzzMPgipeeEThkqi6yolSPtQwYZkJ4WmRihDE7dU9Tv30rUOdllLrYZc0XUPewEFYe-DmjcO4SeRl_EW4_v1SsiLKEaRlvhty-sfXqXw0KF4-IncNPFvisLXAgydc5oyGuqBNW-21-ZKSYl7OFJN2qAZ6aISQrfIW_5dNNUs_I3FkW-iSQS642DW0HefQgrNCS6BOrIK4pD3sGYLu9hlfziVDNPqCGRJ2oBQwSW_KOZJ__uGv0ClRHiKoArKnXVUlpCeUoPt2lZT6xHi0cXHrXwWoaPUVBI4Wv4EcMx9cgiZzgp61yVrXk0vcsb05zz9UJU3WN1mfoaf9FB4tDbwEqsXB9-s2KjzKuTD4stirPYl22_cPSc4N4Phr4TwPmUeAlBi1bX2yw5_rnwYRnixMBiR2GfrT1Hu4gTNloXXbqiQLl7UwbnQ5YJ09zTTEh2CfxUuOI6poufDx21JTrxb
notice how the PCR tests failed on the spike but the "N" picked up the infection
""""causes diagnostic escape in PCR assays using the ‘S’ gene as a target for amplification1,2. The
numerous spike region mutations also raise questions about possible immune escape and/or vaccine
evasion and likelihood of reinfection.""""
really cannot understand why folks are selling scancell .......the science is Highlighting these variants with alarm bells .....
Under the circumstances its clearly in the Gov MHRA interest to design trials for second generation regardless of volunteers availability because of the complex nature of the way this infection is developing we will still be under the influence of the pandemic for at least 1/2 years these variants started to appear in the summer that's only 6 months after initial virus detection so possible major changes are occurring at a rate that is shortening the time due to the enormous amount of virus around the globe
past protocols for trials as we have seen have been accelerated beyond whatever we thought 12 months ago
The Gov is dedicating quite a bit of post brexit resource to this sector
Hi C7,
Just thought it was good practice to post informative information from someone who is very "sharp" on the Scancell front and without any confrontations.
Hope all can extract what they need from this, really miss his personal input over here, a sad loss in my opinion.
Miss the "fight nights" too sometimes. Very entertaining. Just a bit of fun on Fridays
If everybody is happy to accept re-posts then I am happy to continue, best wishes to all.
Take care everybody for the next number of weeks.
ATB
Https://www.ft.com/content/f2794fd0-8a40-4ff1-91fa-78bfa75f519f
Highly contagious new variants of coronavirus will emerge more frequently and spur further infection waves such as those threatening to overwhelm hospitals in the UK and South Africa, one of the world’s leading infectious disease experts has warned.
Salim Abdool Karim, chairman of South Africa’s Covid-19 ministerial advisory committee, also said it was too early to know the extent to which existing vaccines would provide immunity to the new variants.
Scientists around the world have been alarmed by the rapid spread of the new 501.v2 variant first detected in South Africa and the equally infectious B.1.1.7 variant that has led to a surge in cases in the UK. Other variants have emerged recently in Brazil and Japan.
Prof Abdool Karim, the epidemiologist who led South Africa’s fight against HIV/Aids, explained that viruses evolved as they infected people with partial immunity in order to escape recognition by their antibodies.
“We’re going to see this occur more commonly now than in 2020, as we vaccinate and as more people are infected,” he said in an interview with the Financial Times.
The epidemiological finding of increased transmissibility was supported by “biological evidence showing the 501.v2 variant binds more readily and more strongly to human cells”, added Prof Abdool Karim.
--------------------------------------------------------------------------------
any day now ... one of these variants are going to break tolerance of the spike protein vaccines making them weaker and weaker
i would put money on it ......... better buy scancell as Betfred would not give me odds