Member Info for Bunsie

Goodness, I am due my Jab , and the Wife,from AZ at 14.30 Friday! tomorrow!

I thought it would be just like the flue Jab, won't sleep well tonight then. Thanks everyone!

Going for it in any event.

ATB to everyone

Hi Ray,

You are very welcome, just the messenger though, but this is why I enjoyed Inans posting when we get these little gems.

Of course, then much research and thoughts come from all corners, great stuff.

ATB

that "immunotherapy patent "

spotted this

""Future Research"
We have identified a common process that occurs in most cancer that can be recognised by the immune system. This would allow us to design a vaccine to stimulate an immune response which would recognise and kill early cancerous cells. This may have to be boosted yearly as for seasonal flu vaccines. It could be given to people at high risk of cancer or to adults over 60 which are the most common age group for this disease.""

hTTps://www.nottingham.ac.uk/medicine/people/lindy.durrant

click on Research

if its "identified" that then raises the Barr ...

is it the University or Scancell or as we have seen in the past Scancell becomes the vehicle

digging required

We have identified a common process that occurs in most cancer that can be recognised by the immune system. This would allow us to design a vaccine to stimulate an immune response which would recognise and kill early cancerous cells. This may have to be boosted yearly as for seasonal flu vaccines. It could be given to people at high risk of cancer or to adults over 60 which are the most common age group for this disease.
hTTps://www.nottingham.ac.uk/medicine/people/lindy.durrant
Click on research

LL many thanks

I'll look out for it, always interested in the science and LD's presentations.

ATB

Anyone recording Lindy please, or will it get posted on the Scancell site later?
Tanks in advance
ATB

More on Manaus Variant here for anyone interested

https://virological.org/t/sars-cov-2-reinfection-by-the-new-variant-of-concern-voc-p-1-in-amazonas-brazil/596

ATB

Brazil Manaus is the biggest threat to life after vaccination This appears to be a New Phenotype .. A new Linage which they have called P1
This is the Variant that Scancell is concentrating on, its my considered opinion we might be into the summer before this gets to us and could be a very serious issue next "season" The issue is these "variants" are not "individual" they appear to pop up spontaneous with further variations
so just closing borders may not prevent the appearance. The UK 501y variant proves that, with multiple examples of the 501 appearing in other variants for example South Africa

If Scancell can induce an immune response against the "N" which is the conserved area of the Virus, the Scancell vaccine could be essential as a base forming immunity against all variants, I still consider the Scancell vaccine is probably the most valuable vaccine against Covid because of the difficulty in building multivalent vaccines quickly, indeed its not the same as "tweaking" Because Scancell can "Focus" the Lense on vaccination its far more potent than a single Antigen based vaccine like MRNA and Oxfords viral approach this time around Scancell is 6 months ahead rather than being 6 months behind because it is already a multivalent vaccine
https://www.sciencemag.org/news/2021/01/new-coronavirus-variants-could-cause-more-reinfections-require-updated-vaccines

Hi Krafty,

Good to see you still here, a long flog but getting closer to some possible great news I guess.

Seems a long time ago we flew from Gloucester to East Midlands Airport together for the AGM in the business jet!.

Hope you are well and best wishes to you.

Sas,
This extract from your link I find interesting and shows how essential SN14 could be
"These data also have implications for the effectiveness of SARS-CoV-2 vaccines, which are principally
based on immune responses to the spike protein. Neutralizing antibodies have repeatedly been
demonstrated as the primary correlate of protection for most vaccines, including those designed to
prevent infection with respiratory pathogens34
. Despite neutralization escape, we show here that a
significant proportion of non-neutralizing, RBD binding antibodies remain active against 501Y.V2. While
antibody effector functions elicited by infection and vaccination have been implicated in protecting from
reinfection and disease35,36, the role of non-neutralizing antibodies and the efficacy of T cell responses to
501Y.V2 remain to be elucidated. Ultimately, the correlates of protection against SARS-CoV-2 infection
and severe COVID-19 disease remain undetermined and rely upon ongoing large-scale clinical trials.
Nevertheless, the speed and scope of 501Y.V2 mediated immune escape from pre-existing neutralizing
antibodies highlight the urgent requirement for rapidly adaptable vaccine design platforms, and the need
to identify less mutable viral targets for incorporation into future immunogens "
ATB
Thanks for the link too

https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586

"" The recent emergence of variants with multiple shared mutations in spike raises concern about convergent evolution to a new phenotype, potentially associated with an increase in transmissibility or propensity for re-infection of individuals.""

We are so close now ......... You now cannot dispute the value of Covidity if it does generate an immune response against the conserved area
of the Virus ..........

wow !!

Out of 47,780 people who were discharged from hospital in the first wave, 29.4 per cent were readmitted to hospital within 140 days, and 12.3 per cent of the total died.

Study author Kamlesh Khunti, professor of primary care diabetes and vascular medicine at Leicester University, said: “This is the largest study of people discharged from hospital after being admitted with Covid.

“People seem to be going home, getting long-term effects, coming back in and dying. We see nearly 30 per cent have been readmitted, and that’s a lot of people. The numbers are so large.

“The message here is we really need to prepare for long Covid. It’s a mammoth task to follow up with these patients and the NHS is really pushed at the moment, but some sort of monitoring needs to be arranged.”

The study found that Covid survivors were nearly three and a half times more likely to be readmitted to hospital, and die, in the 140 days timeframe than other hospital outpatients.

Prof Khunti said the team had been surprised to find that many people were going back in with a new diagnosis, and many had developed heart, kidney and liver problems, as well as diabetes.

hTTps://www.telegraph.co.uk/news/2021/01/17/almost-third-recovered-covid-patients-return-hospital-five-months/?li_source=LI&li_medium=liftigniter-rhr

Hi C7,
Goodnight too, sleep well.

A bit of telly time now for me.
ATB

Berm,
Sorry to disagree with you on him being banned on this BB, it was on VAL, so a blanket ban prevents him from posting very good information on this SCLP BB, as do you and others IMO

Yes, I agree he should be allowed to return to the SCLP BB.

ADVFN is toxic, you know that and many here just can't visit it, although I do take a look once a day.

I will continue to post only informative posts from him as long as people allow this and don't have me banned.

Everything I re-post is just information, none confrontational, so what is your problem, just don't get that at all.

I also accept that over there on the dark side there are also some very good sources of information, just seems that it is totally unregulated.

ATB anyway, my best regards to you

Ruck, thank you, much appreciated 47.89% is substantial though, still a large holding for us PI's

Regarding re-posting, I don't think that violates LSE either, if it is informative rather than challenging, many posters do the same including Bermuda and others.

IMO excluding information from Inan is detrimental to our BB here on LSE, I have sight of some very interesting information from him, which I have been instructed by Inan NOT to repost, so there you have it.

Is it at the loss to this BB, probably yes.
ATB

Ruck, Sorry but you also had two bites at the cherry, ADVFN and LSE (gazza & Ruck) so that does not stack up, unless you are missing the "fight nights"
ATB

Ray, send me your billing address so I can charge you for my time, haha
ATB

Berm,
I think you miss the point here, Inan was banned through posting on another BB on LSE (VAL I think), so your logic is totally flawed.
I can't belive you would prefer to do without his investigative skills to the detriment of this SCLP BB, unless he has the ability to scratch your itch?

As far as I am concerned, ALL knowledge/ research regarding Scancell should be shared and we can all as adults sift out what we wish.

@Ruck, Could you do your speciality and let me know our PI % holding in Scancell please, it's changed I think withe the "D" word, think we held around 45% last time I looked.

Anyway, happy to read all views without getting upset, happy chappy mostly
ATB

Hi C7,

I think re- posting anything that may be interesting from Inan here is of value to all here, but with the advantage that as it is via a third party there should be no challenge problems which has in the past caused some really big spats.

Just my opinion though, if it is causing problems then just let me know .

IMO we are still quite low on the science front, which is really what this share is all about.

LL, just love my walks, fresh air and try to time my walks for Ken Bruce (R2) and JV again around early afternoon, lifts my spirits until real drinky time which is becoming earlier every month!

Take care everyone, not too long now I hope, can't believe it's going to be 12 months of our lives living like this.

ATB

awonda

"""Thanks very much for sharing the documents!
I think that Scancell's Covidity is the way to go, but I'd caution against taking the failure of PCR tests as the evidence for that statement. (there are many other excellent reasons)
The PCR tests are not based on many bits of the spike and the change of a single base should lead to a PCR failure but should not lead to the failure of a vaccine which will have produced very many antibodies attacking and blocking very many different sites on the spike. I preferred the focus on the very long lasting T-Cell response to the N protein previously highlighted by others as the reason.

I hope I wont be proved wrong when they do cross reactivity testing in the blue boxes of figures 8. (as it would be bad for all of us)"""

--------------------------------------------

the post was related to "re-infection" not a vaccine induced immune response
its not so much as the failure of a vaccine its the resultant efficacy loss

as i have previously tried to explain ... Sterilise rather than just reduce symptoms is the Holy Grail as that would induce herd Immunity

vaccines that still allow infection also allow immune escape of a chance variant

like wise reinfection of a variant keeps the ball rolling ...........

this all highlights why Scancell will remain a highly valued stock if it can induce the Potent T cells as promised

some immune compromised patients have remained infections despite some receiving 3 plasma antibody transfers for over 90 Days