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Mop and bucket for Touk

Did Professor Eggy just get a spanking?

In the ClinicalTrials site update on 13 December, ovarian cancer was kept, albeit renamed as ovarian carcinoma.

https://clinicaltrials.gov/study/NCT04969835?tab=history&a=7&b=8&compareMode=sideBySide#conditions-card

Ovarian cancer featured in the Tempus AI analyses of identified target indications shown in R&D Spotlight 8, slide 7: https://avacta.wistia.com/medias/kbn3w56eye

As with urothelial carcinoma, ovarian carcinoma is likely being kept open as a further option for the development of AVA6000. This could be for Avacta to progress if and when funds allow, for instance following a licence agreement or partnership for TNBC (Avacta could take both STS and ovarian carcinoma forward in Phase 1b) knowing that a treatment for ovarian carcinoma would be of great interest to pharma companies or it could be that one or more pharma companies have an understanding with Avacta to progress this indication if early findings for the indications in the Phase 1b Arms are suitably positive.

So, depending on the early Phase 1b data, lots of potential revenue streams!

Continuing the theme of what's hiding in plain sight, whilst several indications were removed from the ClinicalTrials site with the 13 December update, urothelial carcinoma was added.

https://clinicaltrials.gov/study/NCT04969835?tab=history&a=7&b=8&compareMode=sideBySide#conditions-card

Urothelial carcinoma, "also known as transitional cell carcinoma, is the most common type of bladder cancer, and it can also occur in the ureters, urethra, and renal pelvis" (source: Google AI Overview) and so replaces bladder cancer on the ClinicalTrials site with a more specific bladder cancer indication.

Why do this? The urothelial carcinoma indication does not form part of any Arm in the current Phase 1b trial. One might deduce that the collaboration with Tempus AI has identified this indication as a viable target for AVA6000: "Multiple tumor types identified with ~80% of patients with high expression of FAP and SLFN11" (source: R&D Spotlight 8, slide 7).

So, as has previously been suggested on here, this indication could well be on the list because it being kept open as a further option for the development of AVA6000. This could be for Avacta to progress if and when funds allow, for instance following a licence agreement or partnership for TNBC (Avacta could take both STS and urothelial carcinoma forward in Phase 1b) knowing that a treatment for urothelial carcinoma would be of great interest to pharma companies or it could be that one or more pharma companies have an understanding with Avacta to progress this indication if early findings for the indications in the Phase 1b Arms are suitably positive.

So, which pharma companies would have an interest in this indication? Well, it is more a starting point than an exclusive list, but both Eli Lilly, through their POINT Biopharma acquisition, and Novartis have radioligand assets targetting FAP and Lilly have their canSEEK™ platform licensed from Avacta and Bachovchin. Both of these would, I believe, want to explore the AVA6000 option.

There are of course other companies with an interest in bladder cancer. Many other companies. Here are a couple of lists straight out of Google: 'AstraZeneca, Merck, Pfizer, CG Oncology and Astellas Pharma, among others' and 'CG Oncology, FKD Therapies, Bristol-Myers Squibb, LintonPharm Co., Ltd., ImmunityBio, Inc., Hamlet Pharma AB, Asieris Pharmaceuticals, Pfizer, Taizhou Hanzhong biomedical co.' Also... "There are approx. 80+ key companies which are developing the(sic) therapies for Bladder cancer." (source: Bladder cancer - Pipeline Insight, 2025 (Published 2024, 230pp, Global coverage): https://www.delveinsight.com/report-store/bladder-cancer-pipeline-insight

So, lots of potentially interested pharma companies and not all of them by any means 'Big pharma'.

Those who think the US is a great place to live should perhaps watch some of the many videos on YouTube from Americans who have moved abroad. Safety, quality of life (particularly leisure time, food and less-to-no stress), education and healthcare free at the point of use feature regularly.

On healthcare, one dentist said that when he was working in the US he was pressured to maximise income irrespective of whether patients needed treatment or not.

On education, take a look at any of the "NPC students" or "dumb students" or even "basic questions" videos on YouTube to see the quality of students who are going to be lumbered for life with university fee repayments.

What leadership of an august body allows tampon dispensers in a male bathroom?

And you're saying "the entire medical establishment" is thinking and doing as one?

I think you are conflating arguments here because what you are moaning about is not in the slightest related to the FDA resignation/sacking. Convince me that RFK Jr. is right about vaccines.

Context please VS

"In his letter, which was obtained by The Associated Press, Marks said he was “willing to work” to address the concerns expressed by Robert F. Kennedy Jr. about the safety of vaccinations. But he concluded that wasn’t possible.

"“It has become clear that truth and transparency are not desired by the Secretary, but rather he wishes subservient confirmation of his misinformation and lies,” he wrote.

"The U.S. Department of Health and Human Services did not respond to a request for comment.

"Marks was offered the choice of resigning or being fired by Kennedy, according to a former FDA official familiar with the discussions, who spoke on condition of anonymity because he didn’t have permission to discuss the matter publicly."

...

"Former FDA Commissioner Dr. Robert Califf said the issues raised in Marks’ resignation letter “should be frightening to anyone committed to the importance of evidence to guide policies and patient decisions.”

"“I hope this will intensify the communication across academia, industry and government to bolster the importance of science and evidence,” he wrote.

"The resignation follows news Friday that HHS plans to lay off 10,000 workers and shut down entire agencies, including ones that oversee billions of dollars in funds for addiction services and community health centers across the country."

... and there's more.

https://apnews.com/article/fda-vaccine-chief-peter-marks-resign-rfk-kennedy-7743be11cec4e4e22c50c2ddbcb6bcd8

Draining the swamp?

Commercial AVA6000 could be manufactured and formulated in the US or a low tariff country or a mixture (manufacture and formulation). The cost of production has to go into the calculation as well. The US is a high cost country.

The 3 amigos are willfully ignorant. They will keep spewing the same mindless drivel. Kudos to those who can stand reading their gibberish as a matter of course. Personally, I can't, despite the many laughs they've given me.

Do not feed the troll

Thompi, HarChris, in addition thornogson/eggy/ndn is willfully ignorant, in the pay of Winnifrith, and likely takes his talking points from Winnifrith.

@McMuff, how can knowledge of whether Avacta will pay in cash "clearly" have got out a month before the payment date? Please explain - 'clearly' 'one month' - if you can.

But only in context. best co**** of action.

Course?

Totally right McMuff, this share price drop is completely due to Avacta mismanagement and has absolutely nothing whatsoever to do with Trump upsetting the applecart of global markets and the consequent inflationary fears.

So... can we expect the price to drop as people sell to crystallise a loss, or the price to rise as people spend the last of their ISA allowance at this knockdown price, or for the net effect of the two being to cancel one another out?

It's a step, a baby step, in the right direction, but anyone who thinks this is anything like a NASDAQ quarterly update should take a look here (and note the date):

https://autolus.gcs-web.com/news-releases/news-release-details/autolus-therapeutics-reports-first-quarter-2024-financial

And why release the RNS on a Monday, the start of the week? Could this be the start of something....???

And on the last day of the month.... There was no mention of Coris... could be the last day for Coris?? ...."Transformation into a pure-play therapeutics company"