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@EthicalSkeptic
50 mutation genetic difference dictates 10.3 total years of genetic distance (by well-vetted rates of mutation) from Omicron to Alpha. Apportioned by mutations/arrival time, this places LCA of Alpha-Omicron in April of 2016.
@EthicalSkeptic
Replying to @snackalittle and @DrKellyVictory
Omicron has old genetics. Older than Wuhan Dec 2019... so, we have a problem.
@drakchaurasia
means B.1.1.529 was in existence in bat before 2019 in some bat?
now, same evolved from base coV2 by selective mutations?
@BidoliNicola
Replying to @drakchaurasia @EthicalSkeptic and 2 others
Yes, correct; or rather its "involuted" (incomplete) sequence which, through some portions of the sequence belonging to the Delta variant, suddenly reappeared (re-emerged in complete form).
@drakchaurasia
and, possessing phenotypes, nearby delta?
is there any mean to assess it's virulence from genomic study? comparing it with alfa or kappa?
@EthicalSkeptic
Replying to @drakchaurasia @BidoliNicola and 2 others
Not in a bat - in humans in 2018/19.
https://twitter.com/EthicalSkeptic/status/1466902747773607946
@EthicalSkeptic
Dec 5
OK, through examining the latest Omicron sequence sample QLD-2568 from 2 Dec 2021, & using a well vetted rate of sustained mutation - parsing this genetic distance into the lineages of Alpha and Omicron - I get a divergence (Last Common Ancestor) date of
?????????????? ????????
@ClownBasket
Replying to @EthicalSkeptic
But hosts are needed to get from the common ancestor LCA to Alpha & Omicron. Does this mean that there was no “leak” in Dec 19 but just an announcement of a leak? That both alpha & omicron were already in the population since 2018?
@EthicalSkeptic
Replying to @ClownBasket
Co-rekt
https://twitter.com/EthicalSkeptic/status/1467365370394722304
wonder if bc201 targets any of these mutations on sarscov2 - omicron
https://twitter.com/davidrliu/status/1464714206150807559/photo/1
" The vaccine is inhaled through the mouth into the respiratory tract and lungs to stimulate mucosal immunity that can't be created by intramuscular injections. "
https://news.cgtn.com/news/2021-11-13/World-s-first-inhaled-COVID-19-vaccine-unveiled-159rlyUJn0c/index.html
" Aerosolized inhalable Ad5-nCoV vaccine requires only one-fifth of the dosage of an injected one "
https://www.republicworld.com/world-news/china/china-launches-covid-19-vaccine-that-can-be-inhaled-through-mouth-report.html
LEAKED DOCUMENT shows that Germany has already plans in place for up to SIX total doses!
https://twitter.com/USMortality/status/1460327221508329480
RKI has been preparing the 6th VACCINATION and state of emergency until the end of 2023 since the beginning of September
https://zachariasfoegen.wordpress.com/2021/11/15/rki-bereitet-6-impfung-vor/
@gerdosi
Wow, early robust IFN response makes adaptive immunity almost obsolete in SARS2 infection.
“In immunodeficient mice carrying chronic SARS-CoV-2 infection, SLR14 elicited near-sterilizing innate immunity in the absence of the adaptive immune system.”
https://news.yale.edu/2021/11/10/immune-system-early-responder-can-combat-covid-19
" The molecule, known as SLR14, is a simple, easy to manufacture, loop of RNA that can trigger the production of interferons, a group of proteins produced by immune cells that are key to the body’s innate, or initial, response to infection.
Multiple studies have shown that COVID-19 patients who produce high levels of interferons have far better outcomes than those for whom interferon levels are low during early days of infection. "
“SLR14 therefore holds great promise as a new class of RNA therapeutics that can be applied as antivirals against SARS-CoV-2,” said Akiko Iwasaki, the Waldemar Von Zedtwitz Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale and corresponding author of the paper.
“Moreover, because this RNA-based therapeutic approach is simple and versatile, our study will facilitate pandemic preparedness and response against future respiratory pathogens sensitive to Type I interferons.”
European Pharmaceutical Review
@PharmaReview
The European Medicines Agency’s human medicines committee (CHMP) has recommended authorising Ronapreve and Regkirona for COVID-19.
https://twitter.com/PharmaReview/status/1459136419490840599
5293 Studies for Prostate Cancer
2368 Completed
587 of them have results published
&
val201 deal almost complete
https://clinicaltrials.gov/ct2/results?cond=Prostate+Cancer&term=&cntry=&state=&city=&dist=
some rather have wet-dreams than a deal
and
not bothering that prostate cancer & other sufferers would get more treatment options sooner
again, very same people very upset that their greed was not met & mouth stopped watering / wet dream finished
serious.
Treatments for HIV involve taking antiretroviral drugs.
Protease inhibitors are one of seven classes of antiretroviral drugs.
https://www.medicalnewstoday.com/articles/323872
note
Pfizer says antiviral (protease inhibitor ) pill 89% effective in high risk covid cases 3 hours ago & they started trail on April.
some not liked it ??
https://airtable.com/shrSAi6t5WFwqo3GM/tblEzPQS5fnc0FHYR/viwJJuMA1ioIgAcPs/recl7ajBOejtSgHL8?blocks=bipZFzhJ7wHPv7x9z
#292 sng
Record Update 2
4/11/2021
1:54pm
https://airtable.com/shrSAi6t5WFwqo3GM/tblEzPQS5fnc0FHYR/viwJJuMA1ioIgAcPs/recl7ajBOejtSgHL8?blocks=hide
SP @23.4
reached the potential mentioned at admission document
" Light Science Technologies has a substantial and growing pipeline to date, with a potential aggregate
value of £40.6 million"