Interferon Beta9 Sep 2021 21:59
Considering SNG001 formulation and the method of delivery directly to the lungs I believe that the Phase3 results will be as good as last year.
https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.27072
"Also several evidence supported beneficial effects of IFNs-a/ß on severe MERS-CoV-infected patients19, 20. Different recombinant IFNs (rIFN-a2a, rIFN-a2b, rIFN-ß1a, and rIFN-ß1b) have shown promising effects against MERS-CoV in vitro.21 Regarding similar properties of SARS-CoV-2 with MERS-CoV and SARS-CoV, the abovementioned evidence could be very helpful in selecting promising managements against SARS-CoV-2. Furthermore, SARS-CoV-2 has shown a far greater sensitivity to type I IFNs than SARS-CoV in vitro, which suggests more efficiency in treatment using type I IFNs.
It should be taken into consideration that auto-antibodies (auto-Abs) against type I IFNs have been adverted in some patients. Whereas the severity of COVID-19 was recognized due to neutralizing auto-Abs against type I IFNs among 10% of patients. In such cases, treatment with IFN-? is less effective and it should be redirected to IFN-ß therapy."