RE: Beating cancer6 Jun 2022 14:19
Portage Biotech Summarizes Data Presented at ASCO 2022 Annual Meeting Including Updates from Ongoing PORT-2 Study
Preliminary data from the Phase 1/2 trial of PORT-2 demonstrates favorable safety and tolerability as a monotherapy with translational data supporting its mechanism of action
WESTPORT, Conn., June 06, 2022 (GLOBE NEWSWIRE) -- Portage Biotech Inc. (NASDAQ: PRTG), a clinical-stage immuno-oncology company developing therapies to improve patient lives and increase survival by avoiding and overcoming cancer treatment resistance, today announced that the Company presented early data from its Phase 1/2 study of PORT-2 (IMM60), an invariant natural killer T cell (iNKT) agonist for patients with melanoma and non-small cell lung cancer (NSCLC), at the 2022 American Society of Clinical Oncology (ASCO) meeting. Portage also presented three posters on INT230-6 (PORT-1) in collaboration with Intensity Therapeutics.
“We are encouraged by the preliminary safety profile of PORT-2, which is well tolerated when administered intravenously as a monotherapy at all doses tested, including demonstrating single agent activity in one of the two heavily pre-treated patients treated at the mid dose level,” said Dr. Ian Walters, Chief Executive Officer of Portage Biotech. “Additionally, translational analysis confirms that PORT-2 activates iNKT cells, NK cells and dendritic cells, supporting the mechanism of action to stimulate both the adaptive and innate immune system. We plan to continue to evaluate PORT-2 both as a monotherapy and in combination with pembrolizumab and look forward to sharing additional data later in 2022.”
Dr. Walters added, “We are also pleased to share ongoing progress from our collaborators at Intensity Therapeutics including further proof-of-concept in a randomized Phase 2 study for patients with neoadjuvant breast cancer, as well as updates on the ongoing Phase 2 combination studies with Keytruda and Yervoy in collaboration with Merck and BMS.”
The presentation abstracts are available to registrants through the conference platform. The PORT-2 poster will be added to Portage’s website following the conference.
Presentation Details:
PORT-2 Poster Presentation
Track: Developmental Therapeutics – Immunotherapy
Abstract Title: A Phase 1 first-in-human dose finding/randomized phase 2 study of IMM60 and pembrolizumab (PEM) in advanced melanoma and non-small-cell lung cancer (NSCLC) (IMP-MEL).
Presenter/First Author: Nicholas Coupe, MBBS Oxford University Hospital Oxford, United Kingdom
Abstract Number: 382017
Poster: 237
PORT-1 Presentations
Track: Sarcoma
Abstract Title: INT230-6 monotherapy and in combination with ipilimumab (IPI) across a broad spectrum of refractory soft tissue sarcomas (STS) [Intensity IT-01; BMS#CA184-592].
Presenter/First Author: Matthew Ingham, MD
Abstract Number: 11515
Poster: 420
Track: Developmental Therapeutics – Immunotherapy
Abstract Title: Effect of intratumoral INT23