Dec 11 (Reuters) - An experimental cancer drug developed by
AstraZeneca and Daiichi Sankyo kept metastatic breast cancer at
bay for months in women who had exhausted other treatment
options, its first clinical study showed.
Patients on trastuzumab deruxtecan, also known as DS-8201,
who had already undergone roughly six prior treatment courses,
were saw no further progression for a median of 16.4 months.
Jose Baselga, AstraZeneca's head of oncology
research and development, said this patient group would normally
encounter further cancer deterioration after about six months.
"This is a totally unprecedented clinical benefit," he said
of the so-called antibody-drug conjugate, which links powerful
cell toxins to antibodies that cling to cancer cells, sparing
the healthy ones that would be damaged in normal chemotherapy.
AstraZeneca signed a licensing and collaboration deal in
March which committed the British drugmaker to paying up to $6.9
billion to its Japanese partner Daiichi.
Analysts have said the deal, and a $3.5 billion share issue
to fund it, will require AstraZeneca to focus on cash flow.
Baselga added that as patients exhaust treatment options
each new approach - or line of treatment - that is tried
normally brings a lower clinical benefit than the one before.
The study dubbed DESTINY-Breast01 is the first of an
envisaged 28 trials with trastuzumab deruxtecan.
Later trials will tackle breast cancer in earlier lines of
treatment and also lung and gastric cancer.
"If this benefit is observed in this line of therapy I think
that this drug can be incredibly beneficial in patients with
earlier disease," said Baselga.
Daiichi and AstraZeneca, which said in May that the main
goal of the trial had been met, have already put in a request
for approval with the U.S. Food and Drug Administration.
The full results are due to be presented at the San Antonio
Breast Cancer Symposium this week.
(Reporting by Pushkala Aripaka in Bengaluru and Ludwig Burger
in Frankfurt
Editing by Gopakumar Warrier/Keith Weir/Alexander Smith)
Astrazeneca (AZN)
