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Weir: Citi cuts to sell from neutral, shaves target to 1,850p from 1,950p. Morrison: Oriel downgrades to sell from reduce.Tesco: Oriel downgrades to reduce from hold.Sainsbury: Oriel downgrades to hold from add.Serco: Bank of America downgrades to neutral from buy.Afren: Credit Suisse raises target to 170p from 143p, reiterates outperform.Shire: Credit Suisse reiterates outperform.Talk Talk: Credit Suisse cuts target to 166p from 175p, reiterates outperform stance. Abcam: Collins Stewart upgrades from sell to hold, gives target of 300p; Peel Hunt maintains buy rating and 440p target.Amlin: Nomura keeps buy rating and 383p target; Peel Hunt keeps hold rating and 429p target.Babcock: Panmure Gordon upgrades from hold to buy, target lifted from 780p to 850p.Betfair: Panmure Gordon reiterates buy rating and 1,065p target.Dunelm: Panmure Gordon keeps buy rating and 600p target.IMI: UBS raises target from 900p to 950p, neutral recommendation maintained; Panmure Gordon downgrades from buy to hold, target upped from 1,020p to 1,080p.Laird: UBS lifts target from 165p to 190p, buy rating unchanged.Misys: Merchant Securities reiterates hold recommendation.Ocado: Panmure Gordon keeps sell stance and 50p target.Premier Farnell: Panmure Gordon keeps sell rating and 150p target.Regus: Panmure Gordon downgrades from buy to hold, target left at 110p.SIG: Panmure Gordon reiterates buy rating and 165p target.Wetherspoon: Panmure Gordon keeps hold recommendation and 424p target.William Hill: Nomura ups target from 185p to 190p, reduce rating kept.