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Mike, appreciate you sharing your research here.
@ Mike33
Thanks for your useful research string.
I found all information informative.
And today's news is a very welcome tonic.
This a from Kromek's partners confirming the Nanopore tech they were using and development of bespoke software for a crop desease program.
So although Kromek haven't 'yet' s the core tech Thier using. 2+2 =
https://www.earlham.ac.uk/oxford-nanopore-minion
Think you're right, it's very interesting tho' that they were focused on livestock desease s initially.
It seems to be a trigger Yes/No detector.
Bit more from thier Tech page...
"Initial trials indicate we can detect when a Covid infected person is in a room such as a classroom, aeroplane cabin, or care home lounge or bedroom. The initial development work is well underway to adapt our agricultural solutions to met the challenge that is Covid-19."
"Each array consists of sensors that individually respond to specific odours (the VOCs) to produce an unique response pattern. Complex pattern recognition algorithms are then used to classify, identify, and quantify, the vapours or odours being sampled. This process is not dissimilar to the way a human nose produces diagnostic patterns that the brain recognises."
Against Kromek's tech statement-
"Using Next 3r ofd Generation Sequencing (NGS), the full genome signature is read and compared against databases of existing pathogens, therefore when an emerging novel threat is tested, it can be detected as parts of their genome is shared by close taxonomic relatives. This will then alert, limiting the spread of an outbreak early."
An interesting point. It does however seem inconceivable that the VOC digital fingerprint could vary to any significant degree from one strain to another. Surely it would not be able to tell for example what strain of Salmonella is present in the hen house. I'd be happy to be proven wrong though as almost anything seems possible these days!
I am inclined to think that the Kromek technology will ultimately be superior in this regard.
Oh lost the last bit...try again.
From The Technology page on Thier site-
'Super Sniffing Technology' for fast early detection of disease.
Roboscientific is leading the field providing non-invasive detection of diseases and infestation in a range of living organisms. It has developed the next generation of sensors and sensor arrays combined with fast accurate analysis using the company's bespoke sensors and proprietary software. We use Volatile Organic Compounds (VOCs) to assess the condition of the animal, flock of birds, or crop that is being monitored.
Volatile Organic Compounds (VOCs) are the smells given off by every living being – when its conditions changes, so does its smell. By constantly monitoring the odour given off by that item, we can assess when its condition changes – and by analysing the type and combination of VOCs that we can sense, we can identify the reason for the change.
Not sure how it can identify Covid varients/mutations or wether it has to be loaded with specific sensors for each pato...
Hi Skid, I can only see the first few paragraphs of the Times article. Very interesting and looks like from Thier Tech page on Thier web site that they were working on Live stock and Crop desease detection as we're Earlhams original project goals. It's very compact design by the look of it and I'll see if I can find any published test results.
From Thier site-
"The Roboscientific Covid-19 Air Monitor has the potential to get the world travelling safely. By installing one of our monitors in the cabin of a passenger plane, it would be possible to establish very early in the flight if any of the passengers are carrying the Covid-19 virus.
Roboscientific has developed a new generation of Volatile Organic Compound (VOC) Sensors which are more sensitive and more robust, achieving results which outperform the 'Gold Standard' PCR tests currently available - delivering Sensitivity and Specificity of 98% to 100% in recent trials*. It is completing development of the Room monitor version now and is keen to work with the Aviation Sector to help get the world travelling again by developing an in-flight version which would be capable of sampling the air in-flight and informing the pilot during the flight if there is anyone on-board infected with SARS-CoV2 so they can inform the destination airport to prepare to quarantine the flight."
http://www.roboscientific.com/blog/posts/automatic-in-flight-testing-could-get-the-world-travelling-safely/
The Covid-19 Air Monitor will tell you if someone in the room is transmitting the Covid-19 virus. It is a device which can be installed on the wall, ceiling or a shelf and is powered using normal electrical supply via a 13 amp plug.
It operates by sucking the air through the device to collect Volatile Organic Compounds (VOCs) which are present in the room. VOCs are the chemicals contained within every living organism that are responsible for creating the odours that we give out. The air sampling time will depend on the size of the room - but is expected to be typically 15-30 minutes. Once this has been completed, the VOCs are desorbed and passed over the sensors and the sensor responses analysed to check for the presence of the Covid-19 digital fingerprint. Analysis takes only minutes, after which positive results are automatically sent to the designated person via SMS or email.
The device is programmable to define how often and when the air sampling takes place and to nominate how and where the results will be sent.
Once the process is completed, the data is stored and the monitor refreshed ready to repeat the exercise at the next designated sampling period.
From The Technology page on Thier site-
'Super Sniffing Technology' for fast early detection of disease.
Roboscientific is leading the field providing non-invasive detection of diseases and infestation in a range of living organisms. It has developed the next generation of sensors and sensor arrays combined with fast accurate
Mike.
Article today in the Sunday Times about a cambridge company roboscientific which has a £5k covid detector, has produced detectors in the past for poultry.
Cannot find any link with kromek, with the exception of both receiving govn funds from the same source and a note on Durham uni.
Any ideas on this one?
Just to finish off-
None of the resent Covid detectors I mentioned would be considered for the new Biowatch/BD21 as they don't meet any of the laid down requirements.
With Kromek's £10k/ dollar unit cost fig. from Paul Hills last Equity article
and fully automatic/real time and low running costs it would be a very attractive choice in many locations I think.
With Biowatch the story is a long saga of failed expectations and serious cost overrun's there's even been books written about it
https://blackwells.co.uk/bookshop/product/Biosurveillance--BioWatch-Generation-3-Acquisition-by-Wyatt-E-Fletcher-editor-United-States-Government-Accountability-Office/9781624172199
The last serious attempt at a BioWatch Gen 3 US replacement system being Northrop Grummans. NG-ADS with unit costs i
believe near 100k. This was postponed after a 4 or 5 year development programme costing many 10s of million dollars as it was found to be not sensitive enough to detect half of the pathos it was spec'ed to and prone to many false alarms and breaking down after a few days operation. (Dept Homeland security- req'g 2 weeks)?
https://www.wmddetectorselector.army.mil/detectorPages/209.aspx
From a 2014 Defence news site-
'The last GAO report on the program released in September 2012 said BioWatch 3’s schedule was slipping from deployment in 2016 to 2022, and lifecycle costs were ballooning from the 2009 estimates of $2.1 billion to $5.8 billion in 2011.
The lab-in-a-box goal will continue, said the official and an industry insider.
“Experts from the office of health affairs and the Science and Technology Directorate are exploring potential technologies for future development and deployment to enhance our biodefense capabilities,” the official said.'
So DNA sequencing tech has moved on exponentially since then along with costs becoming very attractive.
Kromeks confident statements are good to here with any initial testing issues likely to be software or alograthism tweeks as the core DNA / RNA tech is well proven and already sold globally with rave reviews
4th
Thermo Fisher. 'AerosolSense' Sampler
'The toaster oven-sized machine collects aerosol samples and traps any pathogens on a removable cartridge—with the ability to completely filter the air of a 1,000-square-foot room in under 20 hours—which is then analyzed in a laboratory using Thermo Fisher’s established TaqPath COVID-19 molecular test kit'
So same same..nothing revolutionary there
Kromek's design being far superior and rated as Gold standard in accuracy, by the RNA Nanopore company compared to all other latest generation sequencing platforms.
https://www.fiercebiotech.com/medtech/thermo-fisher-deploys-sensors-for-detecting-airborne-covid-19
3rd most recent I believe.
BioFlyte
'Sentinel solution includes BioFlyte’s BioCapture™ z720 handheld air sampler and the BioFire Defense, Inc. FilmArray® PCR sample analysis system.'
Samples collected are PCR tested at lab or using Multiplex PCR kit on site? So time/labour/cost + consumables.
Hand held collection device. will nodoubt be useful in some situations. Claimed 1 hour results.
But niether autonomous / networked./ real time.
https://bioflyte.com/2021/05/26/bioflyte-launches-first-field-deployable-airborne-covid-19-detection-system-to-improve-school-and-workplace-safety
Well the other companies that have produced Patho Airborne detection units that have recently released products aimed at Covid 19 detection using consumables and requiring lab testing or confirmation at lab by PCR.
None being Fully autonomous/networked/real time etc.
First 2
Smiths Industries 'Bio Flash'
- using thier Canary tech. which has been around for 1O years+. Since anthrax in US mail room use.
From Smiths info page-
"BioDisk consumables that contain genetically engineered biosensors, expressing both the agent-specific antibodies and the calcium-sensitive bioluminescent molecules that are needed to produce light emission. Each BioDisk contains sixteen cuvettes with different agent-specific biosensors in specific cuvettes. This allows more than one agent of interest to be detected and identified."
The biodisk being periodically collected and sent to a Smith's lab for analysis.
New one inserted and reset
So time and labour and limited varient functionality.
https://www.smithsdetection.com/
Bertin Tech. Coriolis µ (Micro), developed and provided by Bertin Technologies
"Biological particles such as toxins, viruses, bacteria, molds, pollens and spores are collected and concentrated in a liquid ready to be analysed with microbiological, cellular and molecular biology methods."
Cyclone liquid wall? tech that then is has PCR analysis at lab.
-So a collection device.
https://bertin-technologies.com/medias/air-sampler-coriolis-m-micro-used-asia-and-europe-collect-coronavirus-and-help-combat-its
Cheers Misterh. I
agree food security and mass intensive farming practices are a ticking time bomb I recon.
I watched a vid resently about a coughing pig swine desease that was rampant in Malaysia I think 100's of herds had to be culled, resulting in China buying up pig farms around the world to supply thier domestic market. I don't think China has been able to grow or farm its own use in food for some time.
That's great thanks mike33.
I agree that the commercial opportunities for such a device are very exciting.
I was also thinking about intensive farming situations and the early detection, for example, of new and existing strains of infectious bronchitis virus [a Coronavirus in poultry that's plagued the industry for years]
Perhaps Dr Basu wasn't exaggerating when he referred to it as 'disruptive technology'
I'm still digging out some notes about the other airborne companies In the frame...but my thoughts anyhow...for what they're..
Kromeks Patho design consortium with Earlham and Natural museums bio department. + "Undesclosed" RNA Sequencing company.
Started a long before China hit the world with Covid 19.
To put things in perspective the reason detection companies have been attempting to design airborne patho tech for years is the shear size of the replacement £££ market of the very out of date US Biowatch network that has been in place for 15 years+ costing 70-80 mil dollars pa. to operate in less than half the city's / states intended.
''Homeland Security officials earlier had told companies interested in supplying the technology that it would spend $3.1 billion for it during the first five years of operation.''
This above quote from an LA Times article years ago.....and....
"WASHINGTON — Amid concerns about its effectiveness and multibillion-dollar cost, the Department of Homeland Security has canceled plans to install an automated technology that was meant to speed the 24-hour operations of BioWatch, the national system for detecting a biological attack."
The last unit designed by Northrop Grumman over many years was plagued by multiple false negatives. and couldn't detect anthrax.
With initial units deployed breaking down after a few days, and switched off after New Yorks subway mang . had lost confidence in it.
Other articles in the US press have stated Homeland security quoting an initial requirements for 9000+ units nationwide.
At present the programme seems to be on hold as the requirements/tech hasn't lived up to expectations. with Northrop's units costing some 10x? the fig mentioned by Kmks per unit cost.
Kromeks units look to tick all the boxes,
But has to be put thro its paces by the US military and others.
The present and urgently required Covid 19 detection for Civilian, Commercial, Transportation and Military markets have just added to the already very large market opportunities for this new tech.
The Earlham Institute ( kmks partners) were 3 years ago successfully using the very same 3rd generation RNA/DNA sequencing tech. (Now employed by Kmk) with thier own software and alograthisms for an airborne crop desease detection project.
Live stock desease, swine and bird flu + many others being another market Kromek might well be able to sell into as the regular reoccurring outbreaks seem to get ever worse.
I think the full list of potential markets for this tech aren't widely appreciated at the moment, I'm sure that will change with coming press and science articles that emerge with the trails news and product launches.
Thanks yes would be good to hear. Cheers
There are about 3 or 4 other 'airborne patho ' detection product s Launched recently and all bar one requires filters/cassettes/cartridge es etc to be removed and replaced and sent to lab for PCR analysis. None being autoamus able to give results In 30 mins or less as Kromek state.
I'll post a list of them with thier limitations later if youre interested.
Hi misterh, yes you are broadly correct I've followed with interest the completion units as they have been launched.
Kromek s core DNA/RNA 3 generation is unique to them the reluctance to exactly mention them by name. Which is understandable.
When Arnab has said previously that the tech is fully developed his us taking about this 3rd gen tech....it is and very superior in the fact that it reads minute electrical current across a membrane. This is interpreted tho clever software and alograthisms. Which is what Erlwood? Thier partner were working on previously.
As each new variant is discovered it's added to a data base, and I believe I will flag even unknown 'new' ones ..but it early days yet.
https://www.kromek.com/biological-threat-detection-system/
This is always worth watching again....
Am I right in thinking that the detectors made by rival companies such as Smiths have to be loaded with agent specific biosensors [e.g. one biosensor disc for SARS-COV-2 and so on], whereas the Kromek device is able to read the full genome of any pathogen that happens to be present? If therefore say a novel Corona virus or Influenza type A virus were to appear on the scene, does that mean it would only be precisely identified by the Kromek device? If so, that would make it vastly superior and possibly unique in the market.
Is anyone able to shed more light on this?