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DUMBO are you in or out
The flood gates Wil open soon and every one will be talking about us I pray it will be close to phase 2 results and this time will take the news not Oxford Vaccines if not blue Friday then next week
Dimbo- Dumbo - Have you not seen that both Original Vaccines only lasted 3 to 5 mths effectively and that is why we have all just had a 3rd Jab (Booster) and the 4th Booster Jab Trial in Israel has shown that Omicron evades the current vaccinations in when getting a 4th Jab.
So in 3 to 5mths time we will all be back to square one unless we get booster Jab again! Natural immunity when catching also only lasts as long as the effectiveness of a Jab!
Where the hell you been for past 2 years! Trying reading the information that is readily available you absolute clown.
"The government is now openly banking on it". What about the 200+ other governments in the world battling Covid? Are they to just forget about it and carry on on their merry way??? Utterly laughable. This pandemic is global, not UK-centric!
docdaneeka - you are perfect example of why the covid bull run is coming to an end. Vaccination and natural infection should protect everyone from severe disease. The government is now openly banking on it.
Wow! Just phenomenal.
Remember it was originally 900 patients split across 3 regimes.
Placebo
1syringe of product
2syringes of product
Through discussion with the FDA it was decided to reduce to 610 and settle on one drug regime.
Note the multi regime was due to the change of nebuliser from P2.
Rest assured the trial design was well thought out and the FDA where involved in approving it.
Owl, that’s a great little find :)
Well done mate.
Certainly looks optimistic.
623
https://twitter.com/kickoffsocial/status/1484168218621194246?s=20
Fruits, that was it, thanks.
Yes, they included 10 more in case certain people couldn’t complete the trial for whatever reason.
NDN, I’m not sure why you’re worried, the 610 participants was given the green light specifically by the FDA.
I don’t know why anyone is even responding to the troll. We have been through this with him before but he hasn’t even read the protocol. There is a 25% contingency in the trial numbers and it would still have 90% power.
Move on or filter. Just clogs the board up with crap.
I think the extra 10 were to cover anyone who signed up for the clinical trial but failed to see it through, dropping out for whatever reason. It happens. 10 extra would be a decent % over and above to cushion impact of that.
In fact, if I recall correctly, I specifically read that the FDA were the ones who told Synairgen that they can go to 600 patients instead of 900. Synairgen then decided on 610 patients (I don’t know why the extra 10, perhaps just in case some results get an N/A).
It might have come from one of the RNS’ that Synairgen initially released pre commencement of trial.
"I haven’t just thought this up"
No kidding.
NDN, that scenario you describe of not enough trial participants to give meaningful results is extremely unlikely.
Synairgen will have been in liaison with the FDA prior to the start of SPRINTER. They will have been told that 610 trial participants was enough.
NDN - It's always good to be cautious when investing and check you're thinking for confirmation bias. It does feel that the company is exuding confidence on a scale we have never seen from them before in the past. If lukewarm or poor results were incoming then I think comms would have been non existent or minimal - plus they wouldnt be splashing out on new US websites, origin videos, signing new partnerships and posting half a dozen US job opportunities.
I think we can sleep comfortably (albeit impatiently) until P3 results are announced.
I wouldn't worry about that NDN. They worked with the FDA to agree on the protocol and others on here that are much more familiar with trial design than either of us (such as mattml) have covered this repeatedly that the P3 trial is sufficiently powered.
I see Dimbo-Dumbo is back then!!! Yawn........
Tbh Mumbo, I’m beginning to think that you never invested in SNG or NRX now.
It’s interesting that you came on here last week saying that NRX has much more potential market than SNG does.
Subsequently NRX sinks 12% and looks like it’ll go down further, with their market being squeezed tighter and tighter all the time (hence their desperation to get EUA after the first rejection because they haven’t done a full phase 3 trial).
But apparently you have a holding in SNG as well. I don’t understand why you’re not happy?
As I have to keep telling you, SNG001 is not just about Covid, it’s for ALL RESPIRATORY VIRUS’.
It is similar to Heberon in Cuba which has been used for the last two decades. It’s has total multi utility.
For some reason you can’t seem to grasp this.
Western governments will need to stockpile SNG001 Interferon beta to protect against new variants of Covid AND completely new respiratory virus’ (seeing as they emerge every decade or less). It will also be used in asthma and COPD patients. The latter is where Synairgen will either be taken over or have a joint venture with big pharma to develop SNG001’s utility for asthma and COPD.
This is a needed drug. Whereas Zyesami is not so much needed.
This was a very small trial and had complications which i will not go into here. Folks can read the detail in many published articles, if they so wish. Mene Pangolos decided it was not worth pursuing, and a few other drugs at the time, which have since proven to be successful.
In 2016 after AZ dropped the Phase 2a study Professor Stephen Holgate said:
“New treatments to prevent severe exacerbations are needed and most exacerbations are caused by the common cold and flu. Unexpectedly, colds did not cause as many asthma exacerbations as were predicted in this clinical trial population. We hope to learn from the results of this trial which population within severe asthma, or other respiratory diseases, will most benefit from AZD9412 and should be included in future trials.”
Synairgen have learnt lessons. Delta spread through Western world..........Omicicron is spreading through the western world...........
Endpoints have been carefully choreographed for SG018 in breathless patients, more specific than in the P2. I believe the signs a strikingly optimistic, notwithstanding, all we have learned from the P2 and dissected to death (see Lancet)
They know the results already for P3 and have already advertised for numerous positions in the USA and strengthened staff substantially and set up many agreements ready for potential launch.
Tick tock
GLA.
Hoooooooooooooooooooooolllllllllllllllllllllllllllllllllldddddddddddddddddddddddddddd.
Sigh. I'm filter binning him.
This bull@@@t run is over for me.
Mumbo Jumbo is spoken nonsense.
Therefore I applaud you for espousing a view which is just that.
Can you answer any of my questions mumbo? You are going off on any tangent necessary, what has got you upset?
Vaccines wane after 10 weeks, natural immunity wanes too....
Again what about the next variant....why are vaccine makers getting new vaccines made....
Your arguments are incredibly weak probably like yourself ;)
previous infection + vaccines will provide a great barrier to severe disease outcomes
My green bin is filling up nicely with the mumbo-jumbo you are spouting!
GLA