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Ruck you post this ........
"""As of yet, the robustness of the science is inproven. This is why we need the trials to prove it at which point we may be able to convince some big players."""
"""Debating the theory around the science until we are blue in the face doesn't actually "prove" anything. Otherwise, people far more qualified, knowledgeable and intelligent than us would already be doing so, thus avoiding the need for trials.""
then you qualified it with this ...
For the record, I have never said " human blood work and mouse data" is insignificant, it is of course very significant. Without this, I doubt we would even be contemplating human trials and thus have the chance of producing data that people will not only take notice of but invest significant amounts of dosh.
you are trying to please Knowlesi and the BB at the same time ........
Knowlesi will not debate the science for the simple reason he cannot ....
Good programme on London Live TV, which I guess many dont get but wonder if you can on iplayer.
Just about new treatments in cancer from surgery through chemo and beyond, well worth watching if you can, I just wonder how close we all are to returning to human trials??
Thanks for the reply. I do know what you mean, we all use words that we think we know and assume others will interpret them in exactly the same way that we meant them.
I agree that there has been progress the last few years, as you say, Modi has improved. If it has improved on something that is already robust then I'm sure it is true to say that the robustness has improved as well.
As you say, trial data is the key. I'm only repeating what Cliff Holiway has said in presentations past.
Knowlesi does make another good point - it is very difficult to debatewith someone who makes things up about people. For the record, I have never said " human blood work and mouse data" is insignificant, it is of course very significant. Without this, I doubt we would even be contemplating human trials and thus have the chance of producing data that people will not only take notice of but invest significant amounts of dosh.
Chester its pointless discussing it with them .....
Knowlesi .. passed ... so cannot not support his statements
and Ruck does not consider human blood work and mouse data as anything of significance
thus i am not sure why he bought in the past ... or knowlesi for that matter
Fair points, my use of the word robust (meaning: strong, vigorous, strudy) was probably illconcieved. What I meant is that in those 3 years Scancell have not sat idlely by, Motitope has been improved to potentially work in a higher portion of patients, I'm presuming that from the original SCIB 1 trials that some patients are still alive after 8 years and there is the development of AvidiMab.
These facts added together have strengthened Scancells scientific worth.
Trial data it seems is paramount to getting the kind of attention that will bring in the right level of deals.
We need this Covidity platform to be funded soon, which may act as a validation or we need to raise sufficient funding to complete the SCIB1 / Combi and the MODI 1 phase trials.
Inanaco - You don't even know what "debate" means....you ranting filibusters are not debate....so I'll pass, you aren't even close to the required standard.
I think you have to have some sympathy for Knowelsi points.
I agree that there is no chance ll raising £15m at 5p. There would have to be a substantial discount to the prevailing rate which looks to be heading for 5p.
As of yet, the robustness of the science is inproven. This is why we need the trials to prove it at which point we may be able to convince some big players.
Debating the theory around the science until we are blue in the face doesn't actually "prove" anything. Otherwise, people far more qualified, knowledgeable and intelligent than us would already be doing so, thus avoiding the need for trials.
Of course it's more robust, especially the Moditope Platform.
We don't know why there has never been a deal, maybe what has been offered without positive data was derisory and SCLP are holding for a better payday once there is the "proof of the pudding".
Lack of funding is just lack of funding.
Scancell have a wealth of platform IP, Patents and collaborations, what we want now is to fund those approved trials because when those first patients become cancer free even you Knowlesi will be a happy bunny.
Still only one 'p' in opinion Knowlesi. Everyone seems to take the 'p' from your opinion don't they?
Robust science Knowlesi .... in your mind ...
would you like to debate that with me .. or would that take you out of your depth ?
i would hate to cause an accident ... life Guards are few and far between
The hypothesis is the science is more robust the last 3 years and only thing holding us back is funding. One follows the other in my oppinion - good robust science is followed by smart deals/funding. The lack of funding suggests the science isn't all that robust in my mind....
That's the tricky thing about Scancell they have already proved that their technology and understanding of their science works. That's why it's been so frustrating to have not had trials running these past 3 years.
If anything the science is now more robust. The only thing holding Scancell back is the capital to do substantial trials.
I think they could easily raise more funds, my question is how much would we need and I surpose, what is the highest price we could hope for.
OK == BUt WHY THE 100K BUYER ! Imo all bio are money pits .
I doubt that £15m would be enough and it is unlikely that the company can raise 60% of its current market capitalisation without a substantial discount unless a cornerstone investor is involved.
And completing Phase 2 does not mean Phase 3 happens- what happens if the results disappoint.
Ok lets just presume for one minute that we could raise that amount.
So would that be enough cash to see us through to Phase 2 data fully collected and ready to partner Phase 3 ?
or is that too much money as we don't need that much ?
Knowlesi, Knowlesi, Knowlesi....back to your classic sweeping doom & gloom conjecture. You were doing ok the other day with a "slightly" more subtle approach of posting a question to try (quite admirably but poorly IMO) put doubts into peoples mind. But glad to see you're back to old yourself :) It's much easier/simpler just to post straight up doom & gloom rather than be subtle! Am I right or am i right!? :) :)
No chance they can raise 15m. Institutional base isnt big enough. No idea where funding is coming from - it doesnt look great. An update will be well received
If we were totally unsuccessful in being awarded funds to build a 2nd Gen vaccine (which I would find very hard to accept) we need to get back to concentrating on the cancer trials as soon as possible.
My thoughts turn to raising the cash to support those phase 1 and 2 trials.
A 5p open offer for 300,000,000 shares would raise £15,000,000.
Is that enough money to enable Scancell to collect all necessary positive data, ready to partner the phase 3 studies?
IMO, what should also be happening is an impartial scientific assessment of the various vaccines being developed.
Then government funding should be based on these assessments.
I don't know if this is happening.
The chances of the Oxford vaccine being effective were put at 80% by one of the scientists on the project.
The Imperial vaccine has also received funding.
So, perhaps the government feel that they only need to back 2 horses both from the golden triangle at this point; an odds on favourite and an outsider.
What happens if they both fall?
As Bermuda says it is about getting vaccines to the poorest nations.
I doubt whether specific vaccines will be debated.
But it could be a day of announcements. Commitments to projects etc etc....
Scancell does seem to have gone quiet again, so fingers crossed that we hear some good news by Friday...
"when so" should have been "when someone mentioned Scancell were taking part"
Yes, that puzzled me when so
I don't think any vaccine developers are taking part.
It looks more like a political call to arms to me.
Scancell won't be taking part, it's a high level fundraising conference to encourage nations to pledge cash. The primary aim of GAVI is make vaccines available to the poorest nations to ensure worldwide coverage. I can't see how it relates to Scancell at all other than very loosely in that they will probably discuss coverage of any COVID-19 vaccines.
In what way is Scancell taking part.
I've looked at the Sclp website and there is nothing listed about it.
Are we just signed on or actually presenting?