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Technically if you look at the way lfts results are shown
The fist line on the test the T or positive marker, this could indicate an infection realy quickly, the second line C or control is too show the test has worked which obviously takes longer for full confirmation
If negative, you have to weight for the second line to show, as negative and working
With that in mind, As saying 20 minutes this is for complete confirmation as in positiven or negative and correct
So theoretically a positive test could show in minutes, then a maximum 20 mins for 100% confirmation
My point being you should know your infectious probably within the mentioned 5/10 minutes or even less as the Huff post
Then just a weight on full confirmation if that makes sense GLA
Fardistanthills, if you want to immerse yourself, here's a link to the full DPS document set. Just click on 'View Documents'. There's a weekends worth of reading there at a minimum :-) By the way, it's worth checking this link occasionally, as you get Q&A spreadsheets from time to time, detailing questions posed by potential suppliers and associated answers. Cheers
https://health-family-contract-search.secure.force.com/ProSpend__CS_ContractPage?SearchType=projects&uid=a074J000007FcBSQA0&searchStr=&sortStr=Recently+Published&page=1&filters=
Thanks all for the latest on DHSC LFT tendering and specification. SC, the spec doc is fascinating – what you might call a rose tinted spec? Just my observations for what they're worth
It starts by describing the SARS-CoV-2 antigen tests they have seen as either spike protein ‘S’ or nucleocapsid ‘N’ – a Freudian slip? - n before s in my alphabet!
There is emphasis on DHSC not wanting to foreclose the possibility that innovative and effective forms of tests may qualifying later, so plenty of scope for combining Avacta's spike antigen test with Mologic's nucleocapsid antigen-based technology,
It confirms saliva still in the frame - test kit may contain, depending on collection method, a sterile swab or Saliva collection vessel and possibly a funnel for saliva samples.
“Test & Trace requires individual cassettes being uniquely identifiable in order to link the Test to an individual user - ensuring this linkage is imperative for clinical governance purposes and cannot be achieved without a Test & Trace specific, customised identifier format.” This to my mind seems to show the new £8Bn tender is something more than the procurement of just another bunch of LFDs but rather part of a process of integrating point of use testing into Test & Trace? I’m sure others here will be able to fathom this out better than I can.
Reiterates not seeking to purchase tests for which the only specimen collection method specified is nasopharyngeal or oropharyngeal (or both) and uses diagrams to emphasise this – for the avoidance of doubt.
Requires tests “which have been demonstrated to be effective in the testing of (and ideally would have an explicit a statement in the IFU which confirms that they are suitable for testing of) asymptomatic individuals.”
Must be capable of and legally permitted for use as a Self-Test and passed Phase 3A Validation.
The section stating the “objective of the test will be critically undermined if established and emerging strains (variants) of SARS-CoV-2 are not capable of being detected by these LFTs.”
Surely from what AS has hinted this must be a massive plus for Avacta’s S protein, affimer based?
It goes on to say testing is underway at PH “to test the ‘sensitivity’ of Tests in the detection of the UK variant (also called 'Kent Strain', 20I/501Y.V1, VOC 202012/01, or B.1.1.7) and the South African variant (also called 20H/501Y.V2 or B.1.351). It is anticipated that Phase VOC (Variant of Concern) Validation will shortly also include ‘sensitivity’ testing against the Brazil variant (P.1), and may in future include other variants.
Thanks again for posting SC
You see market domination in new cancer treatments everywhere. A 1% improvement in mortality equals all the market whatever the cost uplift.
To your point earlier, Maaatttt, regarding obsessing over government orders, two things:
As one poster mentioned earlier, what a great hedge to have a big govt order in our back pocket, allowing us to then comfortably branch out further afield.
Also, the UK is very well respected in terms of it's genome sequencing, impressive vaccine rollout etc. Other countries will be looking at what the UK are doing as this pandemic progresses. I can't think of a better advertisement for Avacta, than that the UK are using it's test ubiquitously. It would act as a kind of loss leader...so it's well worth swallowing the cheaper prices.
A quick weekend foray in fundy analysis which is obvious nonsense in my opinion.
Anyway I don’t think LFT market is like vaccine market. Once the best test is decided on it will get all the mone. Why use a test you know is slower, more uncomfortable and with less good at S&S. It’s why innova tests were bought by HMG last year. Crap but the best available. They didn’t get lots of different brands
One winner, the others will be nowhere.
I have children who return to school on Monday. This morning we received our third pack of LFT’s. Again, made in China ‘Innova’ tests, with manufacturers instruction for professional use brain ticklers but being deployed by DHSC for home use front of nose? Go figure?
Why do this...well I guess on the one hand we have millions stockpiled and, with the need to get kids back, the feeling is it’s better than nothing. But I think this is more about starting as you mean to go on, albeit at the expense of accuracy. HMG know AN and Saliva are the only sensible options for home use and so, with next gen tests on the horizon, they wish to be consistent with the prescribed methodology and form the right habits.
The way I see it, with CV and CE, Avacta soon hold all the cards. The latter forces the governments hand as I can’t imagine they’d want a best in class , UK pioneered test, to be sold on the continent whilst we languish with an inferior import. UK engine in a UK chassis, wasn’t that what Moonshot was all about?
Just a matter of time. GLA
How’s about we try and save some time. Is there *anything* in that document that isn’t based on Abakta?
This is the first time I've seen mention of the fact that other equivalent regimes of “Phase 3A Validation" will be considered as the equivalent of that undertaken at Porton Down. This, to me, leaves the door open to qualification for the DPS via Avacta's European validation, even in the worse case where we do not currently have a test at PD.
8.4 “Phase 3A Validation” is an evaluation against human samples containing a) SARS-CoV-2
antigens and b) samples that are confirmed as SARS-CoV-2 negative by PCR.
...
...
Phase 3A Validation is currently undertaken at PHE Porton Down. During the duration of the DPS, DHSC may identify
another regime(s), whether or not undertaken at PHE Porton Down, that may or shall be used to achieve the same objective in which event “Phase 3A Validation” shall, for the purposes of this Specification, the DPS Information Document, and any Application, mean validation by such regime.
Avacta's test should be ready any day now....with the Mologic CE. Our own CE with ISO 13485 comes at the end of March.
That could well be our test given we expect to have one ready end of March.
Well that should use up the Chinese.....sorry Innova cr*p, nicely leaving the door open for us!
Haha cheer up thirtle, you've not missed the boat yet might be chance to jump aboard before we hit £200 ex Chi-nah
Timster, what else are we supposed to do without slowly moving graphs to stare at? ;)
To add to my previous point, there was this line in the huffpost article:
“The super-fast results are also seen as transformative by some in the industry, with sources saying that the time has been brought down considerably over the past few months after experimentation with hundreds of different test strips.”
Well, Big Al did contradict the reported promise of a 5-10 minute test by saying current IFU included a 20min wait, but that doesn’t necessarily mean the rest isn’t true.
Gotta love a weekend on the avacta board :)
Is it us?
Probably....
Thanks for the link. Another curious detail:
“8.6 It is important to note that Phase 3A Validation is provided as against the Test with its characteristics at that time. Where a changes is made to those characteristics, for example a change to a component of the Test (such as changing the membrane from nitrocellulose to another substance), then you must inform DHSC of that change so that it can consider whether the Test must be resubmitted for Phase 3A Validation.”
Cytiva’s membrane strip is nitrocellulose. Have Avacta moved away from this? Did they get a slap on the wrist for not notifying DHSC in a timely fashion?
£8 billion just for starters and the unfortunate reality is come September / October with the spread of infection still out of control, and the antibodies from first vaccinated wearing off, the government will finally realise the Chinese and WHO were right after all and mass testing of everyone is the only way out.
I should add that i would love to be wrong on this call
24 carat gold standard test - best in the world ready shortly
DYOR
Sorry, wrong link included in that last message. Here's the correct one.
LATERAL FLOW TESTING SOLUTIONS - DYNAMIC PURCHASING SYSTEM (DPS) - INFORMATION FOR POTENTIAL PROVIDERS
https://health-family-contract-search.secure.force.com/servlet/servlet.FileDownload?retURL=%2Fapex%2FProSpend__CS_ContractPage&file=00P4J00000FUY5VUAX
Interesting, see Page 3, mentions CE marking as a 'Self Test'...maybe explains why Avacta going down this route.
LATERAL FLOW TESTING SOLUTIONS
DYNAMIC PURCHASING SYSTEM (DPS)
INFORMATION FOR POTENTIAL PROVIDERS
https://www.lse.co.uk/ShareChat.asp?ShareTicker=AVCT&share=Avacta&thread=15DE739D-F956-4630-AE11-152E3CCEB909&reply=true
Interesting, see Page 3, mentions CE marking as a 'Self Test'...maybe explains why Avacta going down this route.
Thanks SC. That’s the first time I’ve seen an explicit reference to targeting the spike protein. PresAl said they’re currently assessing their LFD against VOCs which gets a mention. An AN test is now top of the list...
Come on Handshandy, stop psssing about, just give us the £8bn
Some interesting updates shown here on how a test qualifies to be included in the DPS, including 'VOC Validation' - Variants of concern.
https://health-family-contract-search.secure.force.com/servlet/servlet.FileDownload?retURL=%2Fapex%2FProSpend__CS_ContractPage&file=00P4J00000FUY5fUAH