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Michael Masterman introduces Saffron Energy to London AIM Market (LON: SRON)


Premaitha Share Chat (NIPT)



Share Price: 11.50Bid: 11.25Ask: 11.75Change: 0.00 (0.00%)No Movement on Premaitha
Spread: 0.50Spread as %: 4.44%Open: 11.125High: 11.625Low: 11.00Yesterday’s Close: 11.50


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mhw2
Posts: 1,016
Off Topic
Opinion:Strong Buy
Price:11.50
Late trades
Today 03:18
Over a million reported trades after hours today someone is loading up big time. Think that has something to do with today's rise and hopefully whoever it is keeps on topping up. Looking good for the next few months leading up to the court hearing!
 
Intrigue
Posts: 462
Off Topic
Opinion:No Opinion
Price:11.625
Something kicking off?
Fri 12:58
Some SP action
Steve67
Posts: 577
Off Topic
Opinion:No Opinion
Price:11.125
RE: Re: Premaitha Article
Fri 06:45
If they offer us a quid a share I'll forgive them for the writ!
bakky
Posts: 4,259
Off Topic
Opinion:No Opinion
Price:11.125
RE: Re: Premaitha Article
Thu 23:46
what chance Illumina?? lol.
Natdan
Posts: 463
Observation
Opinion:No Opinion
Price:11.125
Re: Premaitha Article
Thu 22:43
Seems the company has just put up the "For Sale" sign: by stealing a march on its rivals with the new testing system as described (complete with algorithms!) it must surely attract the attention of at least one of the big players.
Get the writ trivia out of the way and the blue skies will reappear.
2011revolution
Posts: 187
Off Topic
Opinion:No Opinion
Price:10.75
View Thread (5)
RE: Premaitha article
Thu 07:48
NEW YORK (GenomeWeb) – Premaitha Health has reported that its cell-free DNA-based screen for fetal aneuploidies performed with perfect sensitivity and specificity.

Trisomies 13, 18, and 21 have been increasing in incidence, according to the US Centers for Disease Control and Prevention. But, common screening approaches based on ultrasound findings and other markers have false-positive rates that lead many women to seek an invasive diagnostic procedure like an amniocentesis or chorionic villus sampling when it may not be necessary.

Noninvasive prenatal testing (NIPT) providers — which include Roche's Ariosa, BGI, Illumina, Natera, and Laboratory Corporation of America's Sequenom, in addition to Premaitha and others — say that screening with their tests might bring the numbers of invasive tests performed down by identifying women at the highest risk.

As they reported in Fetal Diagnosis and Therapy this month, Premaitha researchers built an automated next-generation sequencing-based workflow and relied on a cohort of almost 250 high-risk women to develop an algorithm to determine the likelihood of trisomies from circulating fetal DNA. When they gauged their algorithm's sensitivity and specificity on a separate cohort, the researchers reported that their CE-marked in vitro diagnostic test, called Iona, had 100 percent specificity and sensitivity.

"We set out to build a test that could be used by [local labs] and that technicians in two weeks could learn to do genetic testing," William Denman, Premaitha’s chief medical officer said in an interview. "That's why writing this paper was important — to show that we've accomplished that."

Premaitha launched its Iona test in February 2015. Cell-free DNA is extracted from the blood samples and fetal DNA is isolated for sequencing on Life Technology's Ion Proton platform. The results are then fed into Iona's bioinformatics pipeline.

Denman added that the test could be run in a local biochemistry lab without the need for highly trained genetics technicians, and that from extraction to analysis, the test takes three days.

As described in the paper, to develop that screening algorithm, the Premaitha team used a set of 239 samples from women at high risk of trisomies. After excluding four samples — three lacked corresponding invasive diagnostic test results and one was from a woman found to have cancer — this algorithm development set included 36 trisomy 21, 26 trisomy 18, and four trisomy 13 samples.

They tested the model they developed on a separate set of 111 samples, though one sample failed the fetal fraction validity check. They reported that all the Iona-based results matched those provided by amniocentesis or chorionic villus sampling, giving 100 percent sensitivity and specificity.
Hemo
Posts: 122
Off Topic
Opinion:No Opinion
Price:11.125
Yourgene
Thu 07:15
Where is the yourgene approval expected end of Jan?

Newsflow has been good recently but I wonder what is holding this deal up.

It feels like once this is announced in the short term we are just waiting for our day in court.
NiptSteve
Posts: 37
Research
Opinion:No Opinion
Price:11.125
Premaitha article
Wed 21:33
Anybody got access to this who can provide a bit more detail/summary?

Premaitha Reports 100 Percent Sensitivity, Specificity for Iona NIPT Test
Feb 22, 2017 | Ciara Curtin

https://www.genomeweb.com/molecular-diagnostics/premaitha-reports-100-percent-sensitivity-specificity-iona-nipt-test
Bibio
Posts: 2,207
Off Topic
Opinion:No Opinion
Price:11.125
Thought
Wed 11:04
for a second there we had some exciting news - not so.
twix386
Posts: 2,460
Off Topic
Opinion:No Opinion
Price:11.125
come on itsaduster
Wed 09:03
The pre-open price swings around and has no bearing or indication on the future day or next move.
Only after the open bell can you see the tea-leaves. aimho




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