TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

23 Jan 2012 07:00

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are Silence Therapeutics plc attached:ii

2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights

YES

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights

are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments An event changing the breakdown of voting rights

Other (please specify): 3. Full name of person(s) subject to the Richard Bernstein (Pershingnotification obligation:iii Nominees and Hargreave Hale Nominees) 4. Full name of shareholder(s) Pershing Nominees and (if different from 3.):iv Hargreave Hale Nominees

5. Date of the transaction and date on which the threshold is crossed or 18th January 2012 reached: v 6. Date on which issuer notified: 20th

January 2012

7. Threshold(s) that is/are crossed or 3%

reached: vi, vii 8. Notified details:

A: Voting rights attached to shares viii, ix Class/type Situation previous Resulting situation after the triggering transaction of to the triggering shares transaction if possible Number Number Number Number of voting % of voting rights xusing of of of shares rights the ISIN Shares Voting CODE Rights Direct Direct xi Indirect xii Direct Indirect GBP 1p ISIN:

B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financial Expiration Exercise/ Number of voting % of voting instrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted. C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction Type of Exercise price Expiration Exercise/ Number of voting rights % of voting rightsfinancial date xvii Conversion period instrument refers to xix, xx instrument xviii CFD (Spread 4,185,000 Nominal Delta Bet) 0.73 Total (A+B+C) Number of voting rights Percentage of voting rights 22,625,000 3.92%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

Proxy Voting: 10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease

to hold:

12. Date on which proxy holder will cease to hold

voting rights: 13. Additional information: 14. Contact name: Richard Bernstein

15. Contact telephone number:

020 7478 9070

Note: Annex should only be submitted to the FSA not the issuer Annex: Notification of major interests in sharesxxii

A: Identity of the persons or legal entity subject to the notification

obligation Full name (including legal form of legal entities) Richard Bernstein Contact address (registered office for legal entities) 29 Curzon Street, London W1J 7TL Phone number & email 020 7478 9070 Other useful information

(at least legal representative for legal persons)

B: Identity of the notifier, if applicable

Full name Richard Bernstein Contact address 29 Curzon Street, London W1J 7TL Phone number & email 020 7478 9070 -

richard.bernstein@eurovestech.com

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information

For notes on how to complete form TR-1 please see the FSA website.