Director/PDMR Shareholding

Company Epistem Plc

TIDM EHP.L (AIM)

Headline Directors' Shareholdings

Released 10th January 2012

Number

 Epistem Holdings Plc ("Epistem" or the "Company")

Directors' Shareholdings & AGM

Epistem today provides an update regarding the Company's share investment plan, details of which were announced on 13 July 2009

As a result of the subscription for Partnership Shares and the award of Matching Shares, the executive Directors each increased their beneficial interests in the Company by 297 ordinary shares of 1.5p each. These shares were acquired on 2 November 2011, 9 November 2011 and 23 December 2011 at prices of 383p, 383pand 358p respectively.

Following these transactions, the current beneficial interests of the executive Directors are set out below:

Matthew Walls 8,965 (0.10%)

Dr Catherine Booth 983,320 (11.12%)

Dr Jeffrey Moore 15,645 (0.18%)

John Rylands 193,218 (2.18%)

Epistem further announces that all resolutions proposed at the Annual General Meeting held on 14 December 2011 were passed.

For further details please contact:

Epistem Plc

Matthew Walls, CEO +44 161 606 7258

John Rylands, Finance Director +44 161 606 7244

Peel Hunt LLP

James Steel / Vijay Barathan +44 20 7418 8900