Block listing Interim Review

Name of applicant:

Realm Therapeutics plc

Name of scheme:

Executive Omnibus Incentive Plan

Warrants

Figures for all schemes relate to ordinary shares

of 10 pence each

Period of return:

From: 18 August 2016 To: 17 February 2017

Balance of unallotted securities under scheme(s) from previous return:

2,085,362

117,195

Plus: The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Nil

Less: Number of securities issued/allotted under scheme(s) during period:

30,000

Nil

Equals: Balance under scheme(s) not yet issued/allotted at end of period:

2,055,362

117,195

Number and class of securities originally admitted:

* these securities have been adjusted for a 1 for 10 share consolidation which took effect on 2 July 2010

*20,000 and

*378,423 + *32,000 and 200,000

*196,087 and

*21,108

Dates of Admission:

7 August 2006 and 31 August 2007 and 15 August 2012

7 August 2006 and

31 August 2007

Name of contact:

Marella Thorell, Company Secretary

Telephone number of contact:

+1 484-321-2749