Block Admission Return

Name of company:

Proteome Sciences plc

Name of scheme:

Approved Share Option Scheme

Unapproved Share Option Scheme (No. 2)

2004 Share Option Plan

Period of return:

28th March 2012 to 30th September, 2012

Number of ordinary shares of 1 pence each in the company ("Ordinary Shares") not issued under the scheme at the end of the last period:

648,596

Number of Ordinary Shares issued under the scheme during the period:

50,000

Number of Ordinary Shares cancelled under the scheme during the period:

-

Balance of Ordinary Shares under scheme not yet issued at end of period:

598,596

Number and class of Ordinary Shares originally admitted under scheme and the date of admission

1,000,000 Ordinary Shares - 26th October, 2004