SLN.L Regulatory News (SLN)

Silence Therapeutics plc

("Silence" or "the Company")

Directors' dealings

Silence Therapeutics plc, AIM: SLN ('Silence' or 'the Company'), a leader in the discovery, development and delivery of novel RNA interference (RNAi) therapeutics for the treatment of serious diseases, announces that on 18 April 2016 it received notification that, on the same day, the following purchases of ordinary shares in the Company ("Ordinary Shares") were made:

Ali Mortazavi, Chief Executive of the Company, purchased 160,000 Ordinary Shares at a price of 125.00 pence per Ordinary Share.

Stephen Parker, Chairman of the Company, purchased 6,478 Ordinary Shares at a price of 123.31 pence per Ordinary Share.

Following the above purchases, Ali Mortazavi holds a beneficial interest in 1,937,399 Ordinary Shares, representing 2.78% of the Company's issued share capital. Stephen Parker holds 6,478 Ordinary Shares, representing 0.01% of the Company's issued share capital.

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About Silence Therapeutics plc

Our technology harnesses the body's natural mechanisms to create therapeutic effects within its own cells. This technology can selectively silence or replace any gene in the genome, modulating gene expression up as well as down in a variety of organs and cell types, in vivo. We have developed proprietary modifications to improve the robustness of RNA sequences, together with advanced liposomal chemistries to enhance the delivery of therapeutics.