Rm Regulatory News (RM.)

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

RM PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

The Wellcome Trust Limited,

as Trustee of The Wellcome Trust

4. Full name of shareholder(s)  (if different from 3.):iv

As above

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

21 June 2013

6. Date on which issuer notified:

24 June 2013

7. Threshold(s) that is/are crossed orreached: vi, vii

 Crossed 7%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

ORD GBP0.02

6,266,411

6,266,411

7,310,811

7,310,811

7.8178

GB0002870417

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

7,310,811

7.8178

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will ceaseto hold:

12. Date on which proxy holder will cease to holdvoting rights:

13. Additional information:

14. Contact name:

Christopher Weston

15. Contact telephone number:

0207 611 8665

Note: Annex should only be submitted to the FSA not the issuer

Annex: Notification of major interests in share

A: Identity of the persons or legal entity subject to the notification obligation

Full name

(including legal form of legal entities)

The Wellcome Trust Limited, as Trustee of the Wellcome Trust

Contact address

(registered office for legal entities)

215 Euston Road

London

NW1 2BE

United Kingdon

Phone number & email

0207 611 8665

Other useful information

(at least legal representative for legal persons)

Christopher Weston

Head of Investment Services

B: Identity of the notifier, if applicable

Full name

Contact address

Phone number & email

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information

For notes on how to complete form TR-1 please see the FSA website.