65WK.L Regulatory News (65WK)

SANTANDER UK GROUP HOLDINGS PLCSANTANDER UK PLC€30,000,000,000 EURO MEDIUM TERM NOTE PROGRAMMEPUBLICATION OF SUPPLEMENTARY PROSPECTUS

The following supplementary prospectus (the Supplementary Prospectus) has been approved by the UK Financial Conduct Authority and is available for viewing:

Supplementary Prospectus dated 27 October 2021 to the prospectus dated 12 May 2021, as supplemented on 28 July 2021 and 13 August 2021 relating to the €30,000,000,000 Euro Medium Term Note Programme of Santander UK Group Holdings plc and Santander UK plc (the Prospectus).

To view the full Supplementary Prospectus please paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/8061Q_1-2021-10-29.pdf

A copy of the Supplementary Prospectus has been submitted to the National Storage Mechanism and will shortly be available for inspection at: https://data.fca.org.uk/#/nsm/nationalstoragemechanism.

The Supplementary Prospectus will also be available for viewing via:

https://www.santander.co.uk/about-santander/investor-relations/euro-medium-term-note-programme

For further information, please contact:

Medium Term FundingSantander UK plc2 Triton SquareRegent's PlaceLondon NW1 3AN

Tel: +44 (0) 20 7756 7100

Email: mtf@santander.co.uk

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Supplementary Prospectus and the Base Prospectus may be addressed to and/or targeted at persons who are residents of particular countries only (as specified in the Base Prospectus) and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Base Prospectus is not addressed. Prior to relying on the information contained in the Base Prospectus you must ascertain from such Base Prospectus whether or not you are part of the intended addressees of the information contained therein.

This publication of the Supplementary Prospectus does not constitute an offer of securities for sale in the United States. The securities described in the Base Prospectus have not been, and will not be, registered under the U.S. Securities Act of 1933, as amended (the Securities Act), or under any relevant securities laws of any state of the United States of America, and may not be offered or sold in the United States of America or to, or for the benefit of, U.S. persons (as defined in Regulation S of the Securities Act), unless the securities are registered under the Securities Act or an exemption from the registration requirements of the Securities Act is available.

Your right to access this service is conditional upon your compliance with the above requirement.