Member Info for TrickyEFC

Bounce?

Well they have got the bid under 3 now.

sellers winning the swines

Not a bad start

Cheers vinyl.

started off with a few sells this morn.

turn :p

Lead candidate selection - expected by the end of Q3 2025

don't know why i had end of July in my head.

grabs coat and legs it to the exit shouting tomorrow is bluuuuuuuuue.

Am back, missed this or seen it and forgot about it. june 5th rns

Anthony Tennyson, Chief Executive Officer of Solvonis, commented: "SVN-SDN-014 represents a novel, mechanism-driven approach to treating PTSD, an area of significant and persistent clinical need. With candidate synthesis now complete, we are progressing the programme toward formal lead selection and IND-enabling studies."

Friday did the same volume as the rest of the week combined could you be forgiven for thinking maybe a red dot in the morning 🤔💪

£100k buyer started at 34p finished at 38p

if any available on open under 38p my minds made up :p

Glutamate: The most abundant excitatory neurotransmitter, crucial for learning and memory.

Imagine going to University in 5years time in God mode 😂😂

Il shut up now and hope Solvonis can keep progressing this pathway. Not long till we find out

Endorphins: Natural pain relievers and mood boosters

If the science can be proven this sector may become the most intriguing and bonkers thing since Kanye West.

That's why it's massive massive massive.

Would dwarf any valuation we would get off successfull completion of the AUD arm of the business.

Here's a more detailed look at some key neurotransmitters:

Acetylcholine: Involved in muscle action, learning, and memory.

Dopamine: Plays a role in motivation, reward, movement, and pleasure.

Serotonin: Modulates mood, sleep, appetite, and social behavior.

Norepinephrine: Regulates arousal, alertness, and the stress response.

GABA (gamma-aminobutyric acid): The primary inhibitory neurotransmitter, promoting relaxation and sleep.

Glutamate: The most abundant excitatory neurotransmitter, crucial for learning and memory.

Epinephrine (Adrenaline): Part of the "fight-or-flight" response, also involved in metabolism and other functions.

Endorphins: Natural pain relievers and mood boosters.

Histamine: Involved in wakefulness, appetite, and hormone regulation.

If they come back with positive news on this then it will move the share price like nothing before.

In my opinion this is absolutely massive massive massive.

It would open doorways to the brain literally.

Evotec's analysis will provide critical insights into the candidates' ability to modulate neurotransmitter release, a key mechanism underpinning AWKN-SDN-14's therapeutic potential.

Point being that back in March they had 3 of the 6 candidates successfully synthesised. The aim being to find the best candidate. Surely the Nutt would of used the following 4 months to do some science malarkey and have a much clearly picture of how the science currently is holding up.

At the time of the Administration, 50% of the synthesis had been completed, with three development candidates successfully synthesised.

This is from the earlier update march 18th

Synthesis of development candidates.

The synthesis of six development candidates was originally contracted to Charnwood Discovery ("Charnwood"). However, following Charnwood's administration in Q4 2024 (the "Administration") work was temporarily disrupted. At the time of the Administration, 50% of the synthesis had been completed, with three development candidates successfully synthesised.

Awakn has now contracted Concept Life Sciences ("Concept"), the acquirer of Charnwood, to complete the remaining synthesis. Following a brief pause for knowledge transfer, work has now resumed, and completion is expected by end-May 2025.

Said it before that the people inside the company will have an idea on how this has gone so far.

Given that people on the inside have just pumped in £1mill

Only days ago they would be silly to do so if they knew bad news was on its way. If they new bad news was on the way then why oh why buy at a premium when knowing full well bad news could send it below 0.30

Hopefully a nice blue Monday will settle the any worries anyone has.

If this RNs drops and it's good it's to the 5s in short order.

In-vitro screening for SERT, DAT, and NET release - Evotec appointed by Awakn to lead key preclinical testing.

To ensure the highest standard of preclinical validation, Awakn has appointed Evotec, a globally recognised leader in drug discovery and development, to conduct in-vitro screening for SERT, DAT, and NET release activity.

Evotec brings world-class expertise in:

· Neurotransmitter pharmacology

· High-throughput screening

· Precision drug discovery

Evotec's analysis will provide critical insights into the candidates' ability to modulate neurotransmitter release, a key mechanism underpinning AWKN-SDN-14's therapeutic potential.

This in-vitro testing phase, which builds on the positive animal testing results, is expected to be completed by the end of July 2025, aligning with the revised Programme timeline.

6. Preclinical animal testing.

Awakn has previously announced successful preclinical animal testing results for one of the three synthesised candidates. The study demonstrated promising early signs of efficacy, supporting the potential of AWKN-SDN-14 as a next-generation PTSD treatment. These results provide a strong scientific foundation for the next phase of testing.

7. Lead candidate selection.

Following the completion of all preclinical screening, the Company expects to select a lead candidate by the end of Q3 2025, with a view to complete the sixth and final phase of the Programme.

Frankly frank the last placing? Guess ya didn't read the rns.

How can ya churn solid butter.

Https://mugglehead.com/oxford-biodynamics-surges-after-pfizer-trial-backs-blood-based-cancer-test/

Well the cash brought in from those warrants pays half of Dennis salary for the year 😁😜