Member Info for StarKnight

Reposting for new investors GLA

Reposting for new investors GLA

Reposting for new investors GLA

Reposting for new investors GLA

Link to Centres for Disease Control (CDC)

https://www.cdc.gov/coronavirus/2019-ncov/transmission/variant.html

@MrAdventurous
You are welcome
As you stated: - ‘each 'row' is scanned, as the scanner goes past cell after cell, the location of every cell that fluorescences is recorded. 10 scans’
‘The scan of the each 'column' - however it is done mechanically - is a check on the findings from the scanning of the rows. 10 more scans.’
Yes, that is correct on how I would design the matrix test, so that the second set of 10 scans of the columns confirms the locations by detecting the positive cells that were detected on the first pass of 10 scans of the rows. This would act as redundancy ensuring that all positive cells in the 100 matrix would be correctly identified and their locations cross referenced and recorded. This would rule out any false positives as all cells would be scanned twice in the X-axis and the Y-axis.
You mention that ‘The second scan, the scan of the columns, could be used to further characterise the positive cells, e.g., 1) to further quantify the viral load or 2) by using two different aptamers, each adapted to different virus variants and each with a protein that fluoresces at a different wavelength.’
Yes, I would imagine that the second set of scans of the columns could be used to characterize the positive cells detected on the first pass of the scanner and possibly identify the exact mutation name of each of the positive samples so for example cells at locations A10, B2, C3, all would light up like a bulb when exposed to a UV or Laser type light as they test positive for the virus. All the rest of the samples that do not contain the virus will stay dark so you can see you can test 100 samples in a very short amount of time. So, the second set of scans of the columns could possibly detect the exact variant of a m mutated Covid-19 virus as in the chart below.

Positive Cells identified -------- Variant Mutation

- A10 - - United Kingdom (UK), a new variant of SARS-CoV-2 (known as 20I/501Y.V1,
VOC 202012/01, or B.1.1.7)

- B2 - South Africa, another variant of SARS-CoV-2 (known as 20H/501Y.V2 or B.1.351

- C3 - Brazil, a variant of SARS-CoV-2 (known as P.1)

The secondary set of scans of the columns could be used to provide doctors and medical staff in hospitals to tailor the appropriate antiviral drug to each patient tested positive for Covid-19 and the variant mutation of the virus they are infected with e.g., Brazil or South Africa variant.
Also, the secondary set of scans of the columns could be used to identify new variants of the virus which have not yet been discovered and then recorded and the genome distributed to all world-wide health organizations. This test could literally change our world for the good of mankind and not only that all animals that get infected just as humans do.

@imac1
Thanks for your appreciation
All the governments of our world including the UK and USA were totally unprepared for this level of pandemic despite several warnings from the World Health Organization (WHO) and the Bill and Melinda Gates Foundation
https://www.who.int/

https://www.gatesfoundation.org/

They have been warning our governments for years based purely on what the world’s scientist were telling them! Now hundreds of thousands of people have had their lives lost early and into an extremely horrible death!
The whole World needs our test as a matter of extreme urgency! If all proves well and our test is authorised by the MHRA, The EMA and the FDA then an executive order should be enforced to force all capable companies in the world to tool up to mass manufacture our device to then be distributed across the World to save many billions of lives!!!

The main difference between our test is it is under 2 minutes for a YES/NO result and also that it is extremely sensitive in that it can detect very tiny amounts of virus particles indicating that a person is infectious or asymptomatic without them knowing that they are.
It is a totally portable shoebox sized device which does not require trained staff to operate it.

As the Paraytec Covid-19 test is so sensitive it only requires a very small amount of virus particles which it can detect. So, our test can just use a saliva sample taken on a swab from your inside your cheek or mouth! This is much more comfortable than having the very top of your nostrils probed or the back of your throat scraped to gather a sample and though I have not had that type of test taken I have heard many hundreds of reports on it being a very nasty and very uncomfortable experience!

So our test wins again !

IMHO DYOR

Good Luck All

Extract from Paraytec Website
Designed to give a portable test, which can generate a result in a matter of 5 to 10 minutes from a swab provided at the test location and which requires no specialist skills for its operation. It is anticipated that this product will be used in locations where the rapid screening of large numbers of people for presence of COVID-19, or any future emerging pandemic is required.
The key attributes for the testing device that we have determined are as follows:
• Simple swab or saliva sample – no clinical expertise needed
• No complex sample preparation – proprietary single-use cartridge containing analytes
• Simple portable reader – shoebox size
• No clinical training needed – automated test can be used in any location
• Rapid result – sample to result in 5 to 10 minutes, potential for further reduction
• yes/no result – option for quantification of viral load
• Platform technology – can potentially be used to detect multiple virus targets
Scientific Concept
The test involves the deployment of a DNA aptamer – a short, single-stranded DNA molecule that adopts a shape that is complementary to that of the virus surface protein. By coating a test surface with millions of copies of the aptamer molecule, Paraytec’s CAPTURE module can trap Covid-19 virus particles from a swab sample, as they flow over the test surface. Trapped viruses are then instantaneously coated with the SIGNAL GENERATION module, a synthetic chimeric protein, that both recognises the viral surface as well as being highly fluorescent. The resultant fluorescent signal is measured by the novel DETECTION system developed using the company’s proprietary expertise in optics, electronics and software.
The development of our fast and sensitive COVID-19 test project uses a combination of existing intellectual property previously developed by Paraytec and also the creation of a wide range of new intellectual property within the fields of biochemistry, equipment hardware and software. Paraytec has employed specialist patent lawyers to assist with developing a pathway for the protection of the intellectual property and know how that has been developed during the creation of our COVID-19 test and to ensure that all novel intellectual property is protected by patents. Paraytec currently has a suite of five core patents granted and a further three patent applications submitted. Paraytec expects to be filing further additional patent applications over the first two quarters of 2021 as it develops the intellectual property around the COVID-19 test project.

Continued:-

I think the second device type is more likely as it only requires one scanner unit just like a photocopier whereby you copy an A4 page in portrait mode and then another page rotated 90 degrees to the right into landscape mode to be copied and both times the photocopier scanner passes from right to left and then back again both for portrait and landscape modes.
So, the second type test device having only one scanner would be far more cost effective to build, quicker to manufacture and less moving parts which are prone to failure and so more reliable.

So, in both cases test tubes at locations A10, B2, C3, E6 and H9 all would light up like a bulb when exposed to a UV or Laser type light All the rest of the samples that do not contain the virus will stay dark so you can see you can test 100 samples in only 20 passes of the scanner 10 in the X axis and 10 passes in the Y axis
Professor Carl Smythe indicated that the 100 sample Test devices can be stacked together in like a modular fashion, so presumably you could have 10 Covid-19 test devices in a stack all testing each 100 samples so in total you would have 10 X 100 = 1000 tests occurring all at once or even more if you stack more!!
This is truly a Game Changer and will be in my opinion the fastest, most accurate, most portable mass rapid testing device in the World!

DISCLAIMER
These are my own private thoughts on how the Paraytec covid-19 test device might work to detect multiple positive virus samples in a 100-matrix test device and are not to be taken as fact. Do your own research.

Regarding scanning Professor Carl Smythe did state that there would only be 20 scans to get the results of 100 tests.
This could be achieved with multiple positive tests detected in either one of two ways as follows: -

1. There are two scanning units built into the device, one to scan the whole rows A B C D E F G H I J individually which is 10 scans and the second scanner scans the whole columns 1 2 3 4 5 6 7 8 9 10
So, another 10 scans of each column combined is 100 samples scanned by 20 passes from the two scanners.
As there would be 10 scans of the X axis and also 10 scans of the Y axis any positive virus samples will fluoresce and be located by the cross referencing from the X axis and Y axis scans thereby providing accurate locations in the 100 matrix from the cross referencing of the two independent scanners.

2. It could be that there is only one scanner unit in the device which scans the rows A B C D E F G H I J individually which is 10 scan passes of each whole row. Any positive virus samples will fluoresce and their locations in the X-axis will be stored in the device’s hardware memory.
Then once the A to J rows have been scanned the 100-test tube matrix block rotates through 90 degrees to the right.
This effectively places the former columns in the Y axis 1 to 10 into a second X axis which will be located in the device’s memory as the original Y axis columns 1 to 10.
The scanner is then passed over the 100-tube matrix block from right to left just like a photocopier but due to the 90-degree rotation to the right, it is now all the previous columns 1 to 10 that are scanned and any positive virus samples will fluoresce and their locations in the secondary X-axis will be stored in the device’s hardware memory as if they were in the original Y axis locations.
As there would be 10 scans of the X axis and also 10 scans of the Y axis (done in 90-degree rotation) any positive virus samples will fluoresce and be located by the cross referencing from the X axis and Y axis scans in the onboard computer hardware processor and memory.
So, as a result the single scanner unit would be able to identify all positive samples of however many there are in the 100-test tube saliva sample matrix.

Here is my understanding of how does the matrix system work for two, three or more positives in the 10 X 10 matrix?
I must stress that I do not work for Paraytec. I am a Computer Engineer and just by using logic and information supplied by Professor Carl Smythe I have explained how multiple viruses are detected in the matrix 10X10 - 100 vial system however I will try to explain it in more simple terms
Inside the test machine there will be 10 rows labelled A to J each with a test tube containing a saliva sample swab taken from a person’s saliva in place so 10 vials in each row = 100 test tubes. These tubes are also in columns listed from left to right as numbers 1 to 10

--1-2-3-4-5-6--7-8 -9-10
A O O O O O O O O O #

B O # O O O O O O O O

C O O # O O O O O O O

D O O O O O O O O O O

E O O O O O # O O O O

F O O O O O O O O O O

G O O O O O O O O O O

H O O O O O O O O # O

I O O O O O O O O O O

J O O O O O O O O O O

All the 100 samples are painted in a paint (aptamer) that is designed only to light up like a light bulb (Fluoresce) if it is painted onto COVID-19 virus particles when a bright ultra violet type light is shone onto all the 100 test tubes. So, when the light is switched on if every test tube contained saliva samples all 100 test tubes would light up like lighter bulbs on a Christmas Tree! If only 2 test tubes contained infected covid-19 samples then when the UV light is turned on then only those two tubes would light up and the rest would be dark

In my matrix example tubes containing a virus are marked with a # which represents an illuminated (fluoresced) Positive tube.
So, test tubes at locations A10, B2, C3, E6 and H9 all would light up like a bulb when exposed to a UV or Laser type light as they test positive for the virus. All the rest of the samples that do not contain the virus will stay dark so you can see you can test 100 samples in a very short amount of time.
Continued: -

@MrAdventurous
I have spent much time thinking of how I would design the 100-matrix test as I am a Computer Engineer her is what I have come up with!
Regarding your question: -
Thank you StarKnight, but let me be more explicit in my question.

For one positive sample at, say, E6, there are 20 scans, 10 rows with one positive in row E, and 10 columns with one positive in column 6. Hence the positive is at E6.

But day there is a positive at A3 as well. So, rows A and E have positives and columns 3 and 6 have positives. So, one can conclude that there are two positives in the matrix but how to distinguish between A3 +E6 and A6 + E3?

I have asked this question before and received the answer (possibly from yourself?) that extra scans of the options are needed (actually just one in this case, e.g., if A3 is positive then positives are at A3 + E6, if negative then at the other two positions). So, in that case 21 scans are needed.

It can't be that A3 and E6 are identified in the original 20 scans as that would mean that each column in row A has to be examined separately and the scanning of the columns is therefore redundant.

Btw, my background is in chemistry, specifically in the pharma industry. Retired now.

My Answer: -
Regarding the measurements of more than one positive result of a detected virus. All 100 swab samples are coated with the aptamer which only lights up if there is a covid-19 virus present in that sample when illuminated with UV / Laser light.
The following is an extract from Paraytec Covid-19 detection.
The resultant fluorescent signal is measured by the novel DETECTION system developed using the company’s proprietary expertise in optics, electronics and software.
The development of our fast and sensitive COVID-19 test project uses a combination of existing intellectual property previously developed by Paraytec and also the creation of a wide range of new intellectual property within the fields of biochemistry, equipment hardware and software.
So, it looks to me that the proprietary optical microscope with computer hardware and software (most likely AI Artificial Intelligence) looks at the whole 100 swab matrix and picks out all the swabs that are fluorescing noting each location in the 100-sample matrix.

Continued:-

Also Professor Carl Smythe indicated that the 100 sample Test devices can be stacked together so presumably you could have 10 devices in a stack all testing each 100 samples so in total you would have 10 X 100 = 1000 tests occurring all at once or even more if you stack more !!

The test involves the deployment of a DNA aptamer – a short, single-stranded DNA molecule that adopts a shape that is complementary to that of the virus surface protein. By coating a test surface with millions of copies of the aptamer molecule, Paraytec’s CAPTURE module can trap Covid-19 virus particles from a swab sample, as they flow over the test surface. Trapped viruses are then instantaneously coated with the SIGNAL GENERATION module, a synthetic chimeric protein, that both recognises the viral surface as well as being highly fluorescent. The resultant fluorescent signal is measured by the novel DETECTION system developed using the company’s proprietary expertise in optics, electronics and software.

So in simple terms the above is the paint which coats the samples and only the samples that contain covid-19 light up ( Fluoresce) when all exposed to the UV / Laser light the samples painted that do not contain the virus stay dark so all 100 samples tested instantly

Meaning of fluorescence in English

fluorescence
noun [ U ] PHYSICS specialized
UK /fl??'res.?ns/ US /fl??'res.?ns/

light produced by a substance that has absorbed light or other radiation, which has a longer wavelength than the light that has been absorbed:
The compound emits blue fluorescence.

the quality of absorbing light of a short wavelength and producing light of a longer wavelength:
The mechanisms of fluorescence have applications in television, fluorescent lighting, and radiography.
More examples
They check the samples under a microscope for bright-green fluorescence.
The sky glared with the blanched fluorescence of a shaving light.
This phenomenon, known as daylight fluorescence, is common to fluorite from many Weardale locations.
UV radiation is often used in visible spectrophotometry to determine the existence of fluorescence in a given sample.
When submitted to UV light, the image seems to dim the natural fluorescence of the cloth.

@MrAdventurous

Here is my understanding of how does the matrix system work for two, three or more positives in the 10 X 10 matrix?

I must stress that I do not work for Paraytec. I am a Computer Engineer and just by using logic and information supplied by Professor Carl Smythe I have explained how multiple viruses are detected in the matrix 10X10 - 100 vial system however I will try to explain it in more simple terms

Inside the test machine there will be 10 rows labelled A to J each with a test tube containing a saliva sample swab taken from a persons saliva in place so 10 vials in each row = 100 test tubes. These tubes are also in columns listed from left to right as
1 2 3 4 5 6 7 8 9 10

—-1 2 3 4 5 6. 7 8 9 10
A O O O O O O O O O #

B O # O O O O O O O O

C O O # O O O O O O O

D O O O O O O O O O O

E O O O O O # O O O O

F O O O O O O O O O O

G O O O O O O O O O O

H O O O O O O O O # O

I O O O O O O O O O O

J O O O O O O O O O O

All the 100 samples are painted in a paint ( aptamer ) that is designed only to light up like a light bulb ( Fluoresce ) if it is painted onto COVID-19 virus particles when a bright ultra violet type light is shone onto all the 100 test tubes. So when the light is switched on if every test tube contained saliva samples all 100 test tubes would light up like lighter bulbs on a Christmas Tree ! If only 2 test tubes contained infected covid-19 samples then when the UV light is turned on then only those two tubes would light up and the rest would be dark

In my matrix example tubes containing a virus are marked with a # which represents an illuminated ( fluoreced ) tube.
So tubes at locations A 10 , B 2 , C 3 , E 6 and H9 all would light up like a bulb when exposed to a UV or Laser type light All the rest of the samples that do not contain the virus will stay dark so you can see you can test 100 samples at the flick of a light switch VERY VERY FAST TESTING

@kilmahog

Interesting. Regarding medical devices as there are potentially human lives at stake I would think the process would be more in depth but we shall see

@kilmahog

Thanks for your reply

Ref just a tick box that may be the case but are there delays in processing these UKCAs by the HM Government agency responsible for processing them ? I know when ever I have tried to phone HMRC or other departments I’ve been on the phone waiting for hours to get through due to under staffing and cut backs !! So I presume there will be delays with obtaining UKCA ? Especially for medical devices ?

Ref our 2 min Paraytec Rapid COVID-19 test device :- Not only will we need CE to authorise sales into Europe, but due to BREX5H1T we will now need it’s replacement the UKCA ! to allow sales into the U.K. ! This is more unnecessary red tape and b0110cks to slow down ours and every other manufacturer who wants to sell into the U.K.

The UKCA (UK Conformity Assessed) marking is a new UK product marking that is used for goods being placed on the market in Great Britain (England, Wales and Scotland). It covers most goods which previously required the CE marking.

https://www.gov.uk/guidance/using-the-ukca-marking